公开(公告)号：EP1314755B1

公开(公告)日：2010-09-08

申请号：EP02258010.4

申请日：2002-11-20

Applicant: Takemoto Yushi Kabushiki Kaisha ,  Teijin Dupont Films Japan Limited

Inventor： Osaki, Tatsuhiko, c/o Takemoto Yushi ,  Ichihashi, Tetsuo, c/o Teijin DuPont Films

IPC: C08K5/357 ,  C07D265/14

CPC classification number: C07D265/14 ,  C08K5/357

公开(公告)号：EP1976513A2

公开(公告)日：2008-10-08

申请号：EP07716419.2

申请日：2007-01-05

Applicant: SEPRACOR, INC.

Inventor： SHAO, Liming ,  WANG, Fengjiang ,  MALCOLM, Scott, Christopher ,  HEWITT, Michael, Charles ,  BUSH, Larry, R. ,  MA, Jianguo ,  VARNEY, Mark, A. ,  CAMPBELL, Una ,  ENGEL, Sharon, Rae ,  HARDY, Larry, Wendell ,  KOCH, Patrick ,  CAMPBELL, John, E.

IPC: A61K31/381 ,  A61K31/335

CPC classification number: C07D333/20 ,  C07C211/17 ,  C07C211/29 ,  C07C211/40 ,  C07C215/42 ,  C07C215/44 ,  C07C217/52 ,  C07C217/74 ,  C07C323/32 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07D207/06 ,  C07D207/08 ,  C07D211/14 ,  C07D211/16 ,  C07D265/14 ,  C07D277/28 ,  C07D295/06 ,  C07D307/52 ,  C07D317/58 ,  C07D317/72 ,  C07D319/06 ,  C07D491/056

Abstract: The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

Abstract translation: 本发明涉及新的环己胺衍生物及其在治疗和/或预防中枢神经系统（CNS）障碍如抑郁，焦虑，精神分裂症和睡眠障碍中的用途及其合成方法。 本发明还涉及含有本发明化合物的药物组合物，以及抑制来自突触裂缝的内源性单胺如多巴胺，5-羟色胺和去甲肾上腺素的再摄取的方法以及调节一种或多种单胺转运蛋白的方法。

公开(公告)号：EP0927168A1

公开(公告)日：1999-07-07

申请号：EP97937317.0

申请日：1997-08-22

Applicant: THE PROCTER & GAMBLE COMPANY

Inventor： PIKUL, Stanislaw ,  MCDOW-DUNHAM, Kelly, Lynn ,  ALMSTEAD, Neil, Gregory ,  DE, Biswanath ,  NATCHUS, Michael, George ,  TAIWO, Yetunde, Olabisi

IPC: A61K31 ,  A61P1 ,  A61P11 ,  A61P17 ,  A61P27 ,  A61P29 ,  A61P35 ,  A61P43 ,  C07D233 ,  C07D239 ,  C07D243 ,  C07D265 ,  C07D277 ,  C07D279 ,  C07D409 ,  C07D413 ,  C07D487 ,  C07D495

CPC classification number: C07D239/10 ,  C07D233/02 ,  C07D233/38 ,  C07D239/04 ,  C07D243/04 ,  C07D265/06 ,  C07D265/14 ,  C07D277/06 ,  C07D279/06 ,  C07D409/14 ,  C07D413/14 ,  C07D487/04 ,  C07D495/10

Abstract: The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

公开(公告)号：EP0089139A2

公开(公告)日：1983-09-21

申请号：EP83301073.9

申请日：1983-03-01

Applicant: BEECHAM GROUP PLC

Inventor： Southgate, Robert ,  Brown, Pamela

IPC: C07D487/04 ,  A61K31/40

CPC classification number: C07D477/20 ,  C07C29/62 ,  C07C247/00 ,  C07D205/08 ,  C07D265/14 ,  C07F9/5683 ,  C12C11/02 ,  C07C31/36

Abstract: 1. A compound of the formula (II):
or a pharmaceutically acceptable salt or pharmaceutically acceptable ester thereof, wherein R 1 is hydrogen, -CHO or -SO 3 H or a pharmaceutically acceptable salt thereof, R 2 is C 1-6 alkyl or benzyl, and R 3 is an optionally substituted pyrimidinyl group. Processes for the preparation of such compounds and pharmaceutical compositions containing these compounds are also disclosed.

Abstract translation: 1.式（II）的化合物：其中R 1为氢，-CHO或-SO 3 H或其药学上可接受的盐，R 2为 C 1-6烷基或苄基，R 3是任选取代的嘧啶基。 还公开了制备这些化合物的方法和含有这些化合物的药物组合物。

公开(公告)号：EP1976513B1

公开(公告)日：2016-08-24

申请号：EP07716419.2

申请日：2007-01-05

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： SHAO, Liming ,  WANG, Fengjiang ,  MALCOLM, Scott, Christopher ,  HEWITT, Michael, Charles ,  BUSH, Larry, R. ,  MA, Jianguo ,  VARNEY, Mark, A. ,  CAMPBELL, Una ,  ENGEL, Sharon, Rae ,  HARDY, Larry, Wendell ,  KOCH, Patrick ,  CAMPBELL, John, E.

IPC: A61K31/381 ,  A61K31/335

CPC classification number: C07D333/20 ,  C07C211/17 ,  C07C211/29 ,  C07C211/40 ,  C07C215/42 ,  C07C215/44 ,  C07C217/52 ,  C07C217/74 ,  C07C323/32 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07D207/06 ,  C07D207/08 ,  C07D211/14 ,  C07D211/16 ,  C07D265/14 ,  C07D277/28 ,  C07D295/06 ,  C07D307/52 ,  C07D317/58 ,  C07D317/72 ,  C07D319/06 ,  C07D491/056

Abstract: The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

公开(公告)号：EP1874743B1

公开(公告)日：2013-07-17

申请号：EP06769890.2

申请日：2006-04-26

Applicant: Wyeth LLC

Inventor： CHATLAPALLI, Ramarao ,  NAGI, Arwinder ,  POTOSKI, John ,  HELOM, Jean, Louise ,  WILK, Bogdan, Kazimierz ,  RUBEZHOV, Arkadiy, Zinoviy ,  DRAGAN, Vladimir

IPC: C07D265/14 ,  C07D413/04 ,  A61K31/536 ,  A61P15/00

CPC classification number: C07D265/14 ,  C07D413/04

公开(公告)号：EP1409450B1

公开(公告)日：2009-12-09

申请号：EP02750011.5

申请日：2002-07-11

Applicant: ELAN PHARMACEUTICALS, INC. ,  Pharmacia & Upjohn Company LLC

Inventor： GAILUNAS, Andrea ,  TUCKER, John, A. ,  TENBRINK, Ruth ,  MICKELSON, John

IPC: C07C233/35 ,  A61K31/164 ,  A61P25/28

CPC classification number: C07C233/40 ,  C07C235/20 ,  C07C235/34 ,  C07C255/41 ,  C07C271/22 ,  C07C311/06 ,  C07C323/62 ,  C07C2602/10 ,  C07D207/26 ,  C07D207/327 ,  C07D209/08 ,  C07D209/12 ,  C07D209/18 ,  C07D209/30 ,  C07D209/48 ,  C07D211/76 ,  C07D213/38 ,  C07D213/56 ,  C07D213/64 ,  C07D213/74 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D235/16 ,  C07D235/26 ,  C07D237/14 ,  C07D239/20 ,  C07D241/08 ,  C07D241/12 ,  C07D249/04 ,  C07D249/08 ,  C07D249/12 ,  C07D249/18 ,  C07D257/04 ,  C07D261/10 ,  C07D263/56 ,  C07D263/57 ,  C07D263/58 ,  C07D265/14 ,  C07D271/06 ,  C07D275/04 ,  C07D277/34 ,  C07D277/46 ,  C07D277/70 ,  C07D295/088 ,  C07D295/155 ,  C07D307/52 ,  C07D307/54 ,  C07D307/79 ,  C07D307/81 ,  C07D307/91 ,  C07D311/58 ,  C07D317/28 ,  C07D317/60 ,  C07D319/18 ,  C07D321/02 ,  C07D333/22 ,  C07D333/24 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D473/02 ,  C07D487/04

Abstract: Disclosed are compounds of the formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzeheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

Abstract translation: 公开了式（I）的化合物：可用于治疗阿尔茨海默病和其他类似疾病。 这些化合物包括β-分泌酶的抑制剂，其可用于治疗阿尔茨海默病和以哺乳动物中Aβ肽沉积为特征的其它疾病。 本发明的化合物可用于降低Aβ肽形成的药物组合物和治疗方法。

公开(公告)号：EP1948623A2

公开(公告)日：2008-07-30

申请号：EP06804129.2

申请日：2006-09-25

Applicant: Janssen Pharmaceutica, N.V.

Inventor： BHARAT, Lagu ,  LEBEDEV, Rimma ,  PIO, Barbara

IPC: C07D241/44 ,  C07D265/14 ,  C07D265/36 ,  A61K31/538 ,  A61K31/536 ,  A61K31/498 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P29/00 ,  A61P35/00

CPC classification number: C07D265/14 ,  C07D241/44 ,  C07D265/12 ,  C07D265/36

Abstract: The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating RXR mediated disorders. More particularly, the compounds of the present invention are RXR agonists useful for treating RXR mediated disorders.

公开(公告)号：EP1306373B1

公开(公告)日：2007-05-16

申请号：EP01953336.3

申请日：2001-07-30

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： OGAWA, Mikio, Minase Res.Inst.,Ono Pharm.Co,Ltd. ,  TAKAOKA, Y., Minase Res. Inst.Ono Pharm.Co,Ltd. ,  OHHATA, Akira, Minase Res. Inst., Ono Pharm.Co,Ltd

IPC: C07D217/16 ,  C07D405/06 ,  C07D409/06 ,  C07D221/20 ,  C07D491/107 ,  C07D471/10 ,  C07D401/06 ,  C07D413/06 ,  C07D417/06 ,  C07D405/04 ,  C07D401/04 ,  C07D217/18 ,  C07D491/10 ,  C07D471/04 ,  C07D265/16 ,  C07D495/04 ,  A61K31/435 ,  A61K31/495

CPC classification number: C07D221/20 ,  A61K31/472 ,  A61K31/4725 ,  C07D217/16 ,  C07D217/18 ,  C07D265/14 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  C07D471/04 ,  C07D491/04 ,  C07D491/10 ,  C07D495/04

Abstract: 3,4-Dihydroisoquinoline derivative compounds represented by the following general formula (I) (wherein each symbol has the meaning as specified in the description) or nontoxic salts thereof. Because of having a CB2 receptor agonist activity, the compounds represented by the general formula (I) are useful in preventing and/or treating various diseases, for example, asthma, nasal allergy, atopic dermatitis, autoimmune diseases, rheumatish, immnodeficiency, postoperative pain and carcinomatous pain.

公开(公告)号：EP0067517B1

公开(公告)日：1986-02-26

申请号：EP82302308.0

申请日：1982-05-06

Applicant: BEECHAM GROUP PLC

Inventor： Smale, Terence Charles

IPC: C07D498/04

CPC classification number: C07D265/14 ,  C07D205/08