公开(公告)号：EP1558230B1

公开(公告)日：2008-12-31

申请号：EP03774943.9

申请日：2003-10-22

申请人： ABBOTT LABORATORIES

发明人： BENNANI, Youssef, L. ,  BUNNELLE, William, H. ,  CHANG, Sou-Jen ,  CHEMBURKAR, Sanjay, R. ,  CHEN, Jinhua ,  DART, Michael, J. ,  FERNANADO, Dilinie, P. ,  KU, Yi-Yin ,  LOCKWOOD, Mark ,  WANG, Lei

IPC分类号： A61K31/16 ,  A61K31/19 ,  C07C233/00 ,  C07C229/00 ,  C07C61/00 ,  A61P25/00 ,  A61P29/00

CPC分类号： C07C69/753 ,  C07C61/13 ,  C07C61/135 ,  C07C233/58 ,  C07C233/60 ,  C07C233/63 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/10 ,  C07C2602/20 ,  C07C2602/42 ,  C07C2603/95

摘要： The present invention relates to the use of compounds of Formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.

摘要翻译： 本发明涉及式（I）化合物用于治疗癫痫，双相情感障碍，精神障碍，偏头痛，疼痛或运动障碍的用途，并提供神经保护作用。

公开(公告)号：EP1601650A2

公开(公告)日：2005-12-07

申请号：EP04714598.2

申请日：2004-02-25

申请人： ABBOTT LABORATORIES

发明人： KU, Yi-Yin ,  COWART, Marlon, D. ,  SHARMA, Padam, N.

IPC分类号： C07D207/08 ,  C07D295/02 ,  C07D295/18

CPC分类号： C07D207/08 ,  C07D295/027 ,  C07D295/185

摘要： The invention relates to a process according to scheme for preparing 2-methylpyrrolidine and, more particularly, specific enantiomers of 2-methylpyrrolidine. The corresponding 2-Iodomethylderivatives intermediates also are described. Scheme 1 (I)

公开(公告)号：EP1272500B1

公开(公告)日：2005-05-04

申请号：EP00942860.8

申请日：2000-06-15

申请人： Abbott Laboratories

发明人： STONER, Eric J. ,  PETERSON, Matthew J. ,  KU, Yi-Yin ,  CINK, Russell D. ,  COOPER, Arthur J. ,  DESHPANDE, Mahendra N. ,  GRIEME, Tim ,  HAIGHT, Anthony R. ,  HILL, David R. ,  HSU, Margaret, Chi-Ping ,  KING, Steven A. ,  LEANNA, Marvin R. ,  LEE, Elaine C. ,  MCLAUGHLIN, Maureen A. ,  MORTON, Howard E. ,  NAPIER, James J. ,  PLATA, Daniel J. ,  RAJE, Prasad S. ,  RASMUSSEN, Michael ,  RILEY, David ,  TIEN, Jien-Heh J. ,  WITTENBERGER, Steven J.

IPC分类号： C07H17/08 ,  A61K31/70 ,  A61P31/04

CPC分类号： C07H17/08

摘要： In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4'-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

公开(公告)号：EP0891371B1

公开(公告)日：2003-12-10

申请号：EP97905826.0

申请日：1997-02-06

申请人： Abbott Laboratories

发明人： KU, Yi-Yin

IPC分类号： C07H17/08

CPC分类号： C07H17/08

摘要： A process of preparing 6-O-alkylerythromycin A using 9-oximesilyl erythromycin A derivatives is provided. 9-Oximesilyl- and 6-O-alkylerythromycin A derivatives used in the preparation of 6-O-alkylerythromycin A are also provided.

公开(公告)号：EP0966477A1

公开(公告)日：1999-12-29

申请号：EP98904822.0

申请日：1998-02-03

申请人： Abbott Laboratories

发明人： KU, Yi-Yin ,  RILEY, David, A.

IPC分类号： C07H17

CPC分类号： C07H17/08 ,  Y02P20/55

摘要： The disclosed invention relates to novel 3'-N-O, 9-O-oxime protected, 6-O-alkyl erythromycin derivatives of formula (I), a process of preparing the same. The invention also relates to a process of preparing 6-O-alkyl erythromycin A by eliminating the 3'-N-oxide group and 9-O-oxime protecting groups and optionally deprotecting the hydroxy groups at the 2'- and 4''- positions under suitable reaction conditions.