公开(公告)号：EP2376462A1

公开(公告)日：2011-10-19

申请号：EP09775056.6

申请日：2009-12-16

申请人： Abbott Laboratories

发明人： FROST, Jennifer, M. ,  LATSHAW, Steven, P. ,  DART, Michael, J. ,  CARROLL, William, A. ,  PEREZ-MEDRANO, Arturo ,  KOLASA, Teodozyj ,  PATEL, Meena ,  NELSON, Derek, W. ,  LI, Tongmei ,  PEDDI, Sridhar ,  WANG, Xueqing ,  LIU, Bo

IPC分类号： C07D277/46 ,  C07D417/12 ,  C07D513/04 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P11/00 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07D417/12 ,  C07D277/46 ,  C07D513/04

摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein L
1 , A
1 , R
1g , z, R
2 , R
3 , and R
4 are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

公开(公告)号：EP1833824A1

公开(公告)日：2007-09-19

申请号：EP05855099.7

申请日：2005-12-21

申请人： ABBOTT LABORATORIES

发明人： PACE, Jennifer, M. ,  TIETJE, Karin ,  DART, Michael, J. ,  MEYER, Michael, D.

IPC分类号： C07D417/06 ,  C07D413/06 ,  C07D409/06 ,  C07D405/06 ,  C07D401/06 ,  A61K31/404 ,  A61K31/55 ,  A61K31/496 ,  A61K31/454 ,  A61K31/435 ,  A61K31/428 ,  A61K31/422

CPC分类号： C07D403/06 ,  C07D209/12 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

摘要： The present invention provides novel compounds of Formula (I), which are CB2 selective ligands useful for the treatment of pain.

摘要翻译： 本发明提供了式（I）的新型化合物，它们是用于治疗疼痛的CB 2选择性配体。

公开(公告)号：EP1147112B1

公开(公告)日：2003-10-29

申请号：EP00906998.0

申请日：2000-01-25

申请人： ABBOTT LABORATORIES

发明人： BUNNELLE, William, H. ,  CRISTINA, Daniela, Barlocco ,  DAANEN, Jerome, F. ,  DART, Michael, J. ,  MEYER, Michael, D. ,  RYTHER, Keith, B. ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B. ,  TOUPENCE, Richard, B.

IPC分类号： C07D487/08 ,  A61K31/395 ,  A61P25/00 ,  C07D471/08 ,  C07D519/00

CPC分类号： C07D471/08 ,  C07D401/08 ,  C07D487/08

摘要： Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2, and CH2CH2; Z is selected from the group consisting of CH2, CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.

公开(公告)号：EP1562575B1

公开(公告)日：2009-05-20

申请号：EP03777773.7

申请日：2003-10-22

申请人： ABBOTT LABORATORIES

发明人： BENNANI, Youssef, L. ,  CHANG, Sou-Jen ,  CHEMBURKAR, Sanjay, R. ,  DART, Michael, J. ,  FERNANADO, Dilinie, P. ,  GRIEME, Timothy, A.

IPC分类号： A61K31/19 ,  A61P25/08 ,  C07C61/135 ,  C07C69/753 ,  C07C233/58 ,  C07C237/24 ,  C07C61/13

CPC分类号： A61K31/55 ,  A61K31/33 ,  A61K31/397 ,  A61K31/401 ,  A61K31/495 ,  A61K31/537 ,  A61K31/54 ,  C07C61/13 ,  C07C61/135 ,  C07C61/29 ,  C07C69/753 ,  C07C233/58 ,  C07C237/22 ,  C07C2602/18 ,  C07C2602/20 ,  C07C2602/22 ,  C07C2602/24 ,  C07C2603/08 ,  C07C2603/12 ,  C07C2603/62 ,  C07C2603/66

摘要： The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.

摘要翻译： 本发明涉及使用式（I），用于癫痫，双相性精神障碍，精神障碍，偏头痛，疼痛，或运动障碍的治疗中的化合物，并提供神经保护。

公开(公告)号：EP1558230B1

公开(公告)日：2008-12-31

申请号：EP03774943.9

申请日：2003-10-22

申请人： ABBOTT LABORATORIES

发明人： BENNANI, Youssef, L. ,  BUNNELLE, William, H. ,  CHANG, Sou-Jen ,  CHEMBURKAR, Sanjay, R. ,  CHEN, Jinhua ,  DART, Michael, J. ,  FERNANADO, Dilinie, P. ,  KU, Yi-Yin ,  LOCKWOOD, Mark ,  WANG, Lei

IPC分类号： A61K31/16 ,  A61K31/19 ,  C07C233/00 ,  C07C229/00 ,  C07C61/00 ,  A61P25/00 ,  A61P29/00

CPC分类号： C07C69/753 ,  C07C61/13 ,  C07C61/135 ,  C07C233/58 ,  C07C233/60 ,  C07C233/63 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/10 ,  C07C2602/20 ,  C07C2602/42 ,  C07C2603/95

摘要： The present invention relates to the use of compounds of Formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.

摘要翻译： 本发明涉及式（I）化合物用于治疗癫痫，双相情感障碍，精神障碍，偏头痛，疼痛或运动障碍的用途，并提供神经保护作用。

公开(公告)号：EP2146973A2

公开(公告)日：2010-01-27

申请号：EP08745908.7

申请日：2008-04-16

申请人： Abbott Laboratories

发明人： CARROLL, William A ,  DART, Michael, J. ,  PEDDI, Sridhar ,  PATEL, Meena, V. ,  NELSON, Derek, W. ,  LI, Tongmei ,  WANG, Xueqing ,  KOLASA, Teodozyj ,  PEREZ-MEDRANO, Arturo

IPC分类号： C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  A61K31/425 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： A61K31/425 ,  A61K31/427 ,  A61K31/429 ,  A61K31/4436 ,  A61K31/4725 ,  A61K31/5377 ,  C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  Y02P20/582

摘要： The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

摘要翻译： 本申请涉及其中R 1，R 2，R 3，R 4和L如说明书中所定义的式（I）的含异噻唑亚基的化合物，包含此类化合物的组合物，以及使用此类化合物和组合物治疗病症和病症的方法。

公开(公告)号：EP1664045A1

公开(公告)日：2006-06-07

申请号：EP04784568.0

申请日：2004-09-17

申请人： ABBOTT LABORATORIES

发明人： BASHA, Anwer ,  BUNNELLE, William, H. ,  DART, Michael, J. ,  GALLAGHER, Megan, E. ,  JI, Jianguo ,  PACE, Jennifer, M. ,  RYTHER, Keith, B. ,  TIETJE, Karin, R. ,  MORTELL, Kathleen, H. ,  NERSESIAN, Diana, L. ,  SCHRIMPF, Michael, R. ,  LI, Tao

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D471/08 ,  A61K31/435 ,  A61P25/00

CPC分类号： C07D487/08 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04

摘要： Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

公开(公告)号：EP1606244A2

公开(公告)日：2005-12-21

申请号：EP03779179.5

申请日：2003-10-22

申请人： ABBOTT LABORATORIES

发明人： BENNANI, Youssef, L. ,  CHAMBERLIN, Steve, A. ,  CHEMBURKAR, Sanjay, R. ,  CHEN, Jinhua ,  DART, Michael, J. ,  GUPTA, Ashok, K. ,  WANG, Lei

IPC分类号： C07C233/63 ,  C07C233/60 ,  C07C233/58 ,  A61K31/16 ,  A61P25/08 ,  A61P25/06 ,  C07D233/24

CPC分类号： A61K31/16 ,  A61K31/33 ,  A61K31/397 ,  A61K31/54 ,  A61K31/55 ,  C07C233/08 ,  C07C233/58 ,  C07C233/60 ,  C07C233/63 ,  C07C237/22 ,  C07C2601/14 ,  C07D233/24

摘要： The present invention relates to the use of compounds of formula (I)for the treatment of a variety of disorders including, bu t not limited to, epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, neuroprotection, and movement disorders.

摘要翻译： 本发明涉及式（I）化合物用于治疗各种疾病的用途，包括但不限于癫痫，双相情感障碍，精神病学障碍，偏头痛，疼痛，神经保护和运动障碍。

公开(公告)号：EP0950057B1

公开(公告)日：2002-11-13

申请号：EP97952392.5

申请日：1997-12-10

申请人： Abbott Laboratories

发明人： HOLLADAY, Mark, W. ,  ARNERIC, Stephen, P. ,  BAI, Hao ,  DART, Michael, J. ,  LIN, Nan-Horng ,  LYNCH, John, K. ,  OR, Yat, Sun ,  RYTHER, Keith, B. ,  SULLIVAN, James, P. ,  WASICAK, James, T. ,  EHRLICH, Paul, P.

IPC分类号： C07D401/12 ,  A61K31/44 ,  C07D205/04

CPC分类号： C07D401/12 ,  A61K31/4427 ,  A61K31/485 ,  C07D205/04 ,  Y02P20/55 ,  A61K2300/00

摘要： The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：EP0950057A1

公开(公告)日：1999-10-20

申请号：EP97952392.0

申请日：1997-12-10

申请人： Abbott Laboratories

发明人： HOLLADAY, Mark, W. ,  ARNERIC, Stephen, P. ,  BAI, Hao ,  DART, Michael, J. ,  LIN, Nan-Horng ,  LYNCH, John, K. ,  OR, Yat, Sun ,  RYTHER, Keith, B. ,  SULLIVAN, James, P. ,  WASICAK, James, T. ,  EHRLICH, Paul, P.

IPC分类号： A61P25 ,  A61K31 ,  A61P29 ,  C07D205 ,  C07D401 ,  C07D405

CPC分类号： C07D401/12 ,  A61K31/4427 ,  A61K31/485 ,  C07D205/04 ,  Y02P20/55 ,  A61K2300/00

摘要： The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.