公开(公告)号：EP2351840A1

公开(公告)日：2011-08-03

申请号：EP10185670.6

申请日：2001-11-28

申请人： Amgen Inc. ,  AMGEN CANADA INC.

发明人： Shahinian, Arda ,  Bladt, Anna Tafuri ,  Senaldi, Giorgio ,  Mak, Tak Wah ,  Yoshinaga, Steven Kiyoshi

IPC分类号： C12N15/11 ,  C12N15/12 ,  C12N15/62 ,  C07K14/705 ,  C07K16/28 ,  A01K67/027 ,  G01N33/577 ,  G01N33/68

CPC分类号： C07K16/2827 ,  A01K2217/05 ,  A01K2217/075 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/30

摘要： Novel polypeptide which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding said polypeptides, and vectors and host cells for expressing same are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.

摘要翻译： 公开了包含参与T细胞活化的受体 - 配体对的新型多肽。 还公开了编码所述多肽的核酸分子，以及用于表达其的载体和宿主细胞。 多肽或其激动剂及其拮抗剂用于治疗T细胞介导的病症。

公开(公告)号：EP2397498A3

公开(公告)日：2013-11-27

申请号：EP11004893.1

申请日：2006-07-18

申请人： Amgen, Inc ,  Medarex, Inc.

发明人： Siu, Gerald ,  Shen, Wenyan ,  Yoshinaga, Steven Kiyoshi ,  Huang, Haichun

IPC分类号： C07K16/28 ,  A61P37/00 ,  A61P11/06 ,  A61K39/395 ,  G01N33/68 ,  G01N33/577 ,  C12N15/13 ,  C12N5/10 ,  C07K16/18

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2827 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.

公开(公告)号：EP2397497A3

公开(公告)日：2013-11-27

申请号：EP11004892.3

申请日：2006-07-18

申请人： Amgen, Inc ,  Medarex, Inc.

发明人： Siu, Gerald ,  Shen, Wenyan ,  Yoshinaga, Steven Kiyoshi ,  Huang, Haichun

IPC分类号： C07K16/28 ,  A61P37/00 ,  A61P11/06 ,  A61K39/395 ,  G01N33/68 ,  G01N33/577 ,  C12N15/13 ,  C12N5/10 ,  C07K16/18

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2827 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.

摘要翻译： 本发明提供了与人B7相关蛋白-1（B7RP1）相互作用或结合的抗体和由此结合并中和B7RP1功能的抗体。 本发明还提供了所述抗体的药物组合物和通过施用药物有效量的抗B7RP1抗体来中和B7RP1功能，特别是用于治疗免疫病症（例如，不适当的免疫应答）的方法。 还提供了使用抗B7RPI抗体检测样品中B7RP1量的方法。

公开(公告)号：EP2388276A2

公开(公告)日：2011-11-23

申请号：EP11004890.7

申请日：2006-07-18

申请人： Amgen, Inc ,  Medarex, Inc.

发明人： Siu, Gerald ,  Shen, Wenyan ,  Yoshinaga, Steven Kiyoshi ,  Huang, Haichun

IPC分类号： C07K16/28 ,  A61P37/00 ,  A61P11/06 ,  A61K39/395 ,  G01N33/68 ,  G01N33/577 ,  C12N15/13 ,  C12N5/10

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2827 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.

公开(公告)号：EP2332978A1

公开(公告)日：2011-06-15

申请号：EP10010892.7

申请日：2000-01-27

申请人： Amgen, Inc

发明人： Yoshinaga, Steven Kiyoshi

IPC分类号： C07K14/705 ,  C12N15/00 ,  C07K16/28

CPC分类号： C07K14/70532 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/70521 ,  C07K2319/00

摘要： Novel polypeptides which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding said polypeptides, and vectors and host cells for expressing same are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.