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公开(公告)号：EP3867238A1
公开(公告)日：2021-08-25
申请号：EP19801996.0
申请日：2019-10-17
申请人： Array BioPharma Inc.
发明人： BLAKE, James F. , BOYS, Mark Laurence , CHICARELLI, Mark Joseph , COOK, Adam , ELSAYED, Mohamed S. A. , FELL, Jay B. , FISCHER, John P. , HINKLIN, Ronald Jay , MCNULTY, Oren T. , MEJIA, Macedonio J. , RODRIGUEZ, Martha E. , WONG, Christina E.
IPC分类号： C07D401/04 , C07D471/04 , C07D519/00 , A61P35/00 , A61K31/498 , A61K31/4985
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公开(公告)号：EP3523301A1
公开(公告)日：2019-08-14
申请号：EP17787843.6
申请日：2017-10-10
申请人： Array Biopharma Inc.
发明人： ANDREWS, Steven W. , ARONOW, Sean , BLAKE, James F. , BRANDHUBER, Barbara J. , COOK, Adam , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , MCFADDIN, Elizabeth A. , MCKENNEY, Megan L. , MCNULTY, Oren T. , METCALF, Andrew T. , MORENO, David A. , TANG, Tony P. , REN, Li
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
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13.发明公开
公开(公告)号：EP3365335A1
公开(公告)日：2018-08-29
申请号：EP16791228.6
申请日：2016-10-24
发明人： ANDREWS, Steven W. , BLAKE, James F. , COOK, Adam , GUNAWARDANA, Indrani W. , HUNT, Kevin W. , METCALF, Andrew T. , MORENO, David , REN, Li , TANG, Tony P.
IPC分类号： C07D401/14 , C07D403/14 , A61K31/444 , A61P35/00
CPC分类号： C07D403/14 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D413/14 , C12Q1/6886 , G01N33/574
摘要： and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which X, R1, R2, R3, Ring A and z have the meanings given in the specification, which are inhibitors of FGFR1, FGFR2, FGFR3 and/or FGFR4 and are useful in the treatment and prevention of diseases which can be treated with an FGFR inhibitor, including diseases or disorders mediated by FGFR1, FGFR2, FGFR3 and/or FGFR4.
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公开(公告)号：EP3144303A1
公开(公告)日：2017-03-22
申请号：EP16170994.4
申请日：2009-06-24
发明人： BURGESS, Laurence, E. , CLARK, Christopher, T. , COOK, Adam , CORRETTE, Christopher, P. , DELISLE, Robert, Kirk , DOHERTY, George, A. , HUNT, Kevin, W. , ROMOFF, Todd , KIM, Ganghyeok
IPC分类号： C07D311/04 , C07D405/12 , C07D407/12 , A61K31/353 , A61P29/00 , C07D311/58
CPC分类号： C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12
摘要： A compound which is 6-chloro-7-(4-(4-chloro-2-methoxyphenethylcarbamoyl)-phenoxy)chroman-4-carboxylic acid, or a pharmaceutically acceptable salt thereof. Said compound is either a racemic mixture or a single enantiomer, preferably Enantiomer 2 of 6-chloro-7-(4-(4-chloro-2-methoxyphenethylcarbamoyl)phenoxy)chroman-4-carboxylic acid, or a pharmaceutically acceptable salt thereof, in particular its sodium salt. Said compound for use in treating an immunologic disorder in a mammal.
摘要翻译： 6-氯-7-（4-（4-氯-2-甲氧基苯乙基氨基甲酰基） - 苯氧基）苯并二氢吡喃-4-羧酸或其药学上可接受的盐的化合物。 所述化合物是外消旋混合物或单一对映异构体，优选6-氯-7-（4-（4-氯-2-甲氧基苯乙基氨基甲酰基）苯氧基）苯并二氢吡喃-4-羧酸的对映异构体2或其药学上可接受的盐， 特别是其钠盐。 用于治疗哺乳动物免疫学障碍的所述化合物。
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公开(公告)号：EP3089980A1
公开(公告)日：2016-11-09
申请号：EP14827387.3
申请日：2014-12-29
发明人： BLAKE, James, F. , COOK, Adam , GAUDINO, John , GUNAWARDANA, Indrani, W. , HICKEN, Erik, James , HUNT, Kevin, W. , LYON, Michael , METCALF, Andrew, T. , MOHR, Peter, J. , MORENO, David, A. , NEWHOUSE, Brad , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , GAZZARD, Lewis , SCHMIDT, Jane , DO, Steve
IPC分类号： C07D487/04 , A61K31/444 , A61K31/506 , A61P29/00
CPC分类号： C07D471/04 , A61K31/444 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D519/00
摘要： Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.
摘要翻译： 提供式I化合物或其立体异构体，互变异构体或药学上可接受的盐，其可用于治疗疾病。 公开了使用式I化合物或其立体异构体，互变异构体或药学上可接受的盐在体外，原位和体内诊断，预防或治疗这些疾病或相关病理学病症的方法。
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公开(公告)号：EP3906234A1
公开(公告)日：2021-11-10
申请号：EP20701499.4
申请日：2020-01-02
申请人： Array BioPharma Inc.
IPC分类号： C07D401/14 , A61P35/00 , A61K31/495 , A61K31/4709
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公开(公告)号：EP3523302A1
公开(公告)日：2019-08-14
申请号：EP17787844.4
申请日：2017-10-10
申请人： Array Biopharma, Inc. , McFaddin, Elizabeth A. , McKenney, Megan L. , McNulty, Oren T. , Metcalf, Andrew T. , Moreno, David A. , Ramann, Ginelle A. , Tang, Tony P. , Ren, Li , Walls, Shane M.
发明人： ANDREWS, Steven W. , ARONOW, Sean , BLAKE, James F. , BRANDENHUBER, Barbara J. , COLLIER, James , COOK, Adam , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R.
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
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公开(公告)号：EP3089980B1
公开(公告)日：2018-01-31
申请号：EP14827387.3
申请日：2014-12-29
发明人： BLAKE, James, F. , COOK, Adam , GAUDINO, John , GUNAWARDANA, Indrani, W. , HICKEN, Erik, James , HUNT, Kevin, W. , LYON, Michael , METCALF, Andrew, T. , MOHR, Peter, J. , MORENO, David, A. , NEWHOUSE, Brad , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , GAZZARD, Lewis , SCHMIDT, Jane , DO, Steve
IPC分类号： C07D487/04 , A61K31/444 , A61K31/506 , A61P29/00
CPC分类号： C07D471/04 , A61K31/444 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D519/00
摘要： Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.
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公开(公告)号：EP2379535B1
公开(公告)日：2016-06-15
申请号：EP09793682.7
申请日：2009-12-18
申请人： Array Biopharma Inc.
发明人： COOK, Adam , HUNT, Kevin, W. , DELISLE, Robert Kirk , ROMOFF, Todd , CLARK, Christopher, T. , KIM, Ganghyeok , CORRETTE, Christopher, P. , DOHERTY, George, A. , BURGESS, Laurence, E.
IPC分类号： C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , A61K31/353 , A61P29/00
CPC分类号： C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12
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公开(公告)号：EP2307397B1
公开(公告)日：2014-08-20
申请号：EP09770959.6
申请日：2009-06-24
发明人： BURGESS, Laurence, E. , CLARK, Christopher, T. , COOK, Adam , CORRETTE, Christopher, P. , DELISLE, Robert, Kirk , DOHERTY, George, A. , HUNT, Kevin, W. , ROMOFF, Todd , KIM, Ganghyeok
IPC分类号： C07D311/04 , C07D405/12 , C07D407/12 , A61K31/353 , A61P29/00
CPC分类号： C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12
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