公开(公告)号：EP2167501A1

公开(公告)日：2010-03-31

申请号：EP08779347.7

申请日：2008-06-05

申请人： AstraZeneca AB

发明人： CLAYTON, Joshua ,  EGLE, Ian ,  EMPFIELD, James ,  FOLMER, James ,  ISAAC, Methvin ,  MA, Fupeng ,  SLASSI, Abdelmalik

IPC分类号： C07D413/14 ,  A61K31/496 ,  A61P25/00

CPC分类号： C07D413/14 ,  C07D413/04 ,  C07D487/08

摘要： Compounds of Formula (I) wherein R1, R2, R3 R4 and Q are as described in the specification, pharmaceutically- acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.

公开(公告)号：EP2114940A1

公开(公告)日：2009-11-11

申请号：EP08728676.1

申请日：2008-01-31

申请人： AstraZeneca AB

发明人： SLASSI, Abdelmalik ,  ISAAC, Methvin ,  CLAYTON, Joshua ,  EGLE, Ian ,  JOSEPH, Babu ,  MA, Fupeng

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P25/00

CPC分类号： C07D471/04

摘要： Compounds of formula I: wherein R1, R2, R3,R4, R5, R6, R7, R8 and n are defined in the specification, methods for using said compounds, methods for making said compounds and pharmaceutical compositions containing said compounds.

公开(公告)号：EP1912939A1

公开(公告)日：2008-04-23

申请号：EP06720758.9

申请日：2006-02-15

申请人： AstraZeneca AB

发明人： VAN WAGENEN, Bradford ,  UKKIRAMAPANDIAN, Radhakrishnan ,  CLAYTON, Joshua ,  EGLE, Ian ,  EMPFIELD, James ,  ISAAC, Methvin ,  MA, Fupeng ,  SLASSI, Abdelmalik ,  STEELMAN, Gary ,  URBANEK, Rebecca ,  WALSH, Sally

IPC分类号： C07D209/46 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D417/04 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/4035 ,  A61P25/00

CPC分类号： C07D401/04 ,  C07D209/46 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D417/04

摘要： Compounds of formula (I), wherein R1 is a ring , and uses of the compounds in therapy as metabotropic glutamate receptors modulators, particularly in neurological and psychiatric disorders.

公开(公告)号：EP1833800A1

公开(公告)日：2007-09-19

申请号：EP05855204.3

申请日：2005-12-22

申请人： AstraZeneca AB ,  NPS PHARMACEUTICALS, INC.

发明人： BALESTRA, Michael, c/o AstraZeneca Wilmington ,  BUNTING, Heather, c/o AstraZeneca Wilmington ,  CHEN, Deborah, c/o GlaxoSmithKline N&GI CEDD ,  EGLE, Ian ,  FORST, Janet, AstraZeneca Wilmington ,  FREY, Jennifer ,  ISAAC, Methvin ,  MA, Fupeng ,  NUGIEL, David, c/o AstraZeneca Wilmington ,  SLASSI, Abdelmalik ,  STEELMAN, Gary, c/o AstraZeneca Wilmington ,  SUN, Guang-ri ,  SUNDAR, Babu, c/o AstraZeneca Wilmington ,  UKKIRAMAPANDIAN, Radhakrishnan ,  URBANEK, Rebecca A., c/o AstraZeneca Wilmigton ,  WALSH, Sally, c/o AstraZeneca Wilmington

IPC分类号： C07D231/22 ,  C07D231/20 ,  A61P25/28

CPC分类号： C07D401/14 ,  C07D211/62 ,  C07D231/22 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D413/14 ,  C07D417/12 ,  C07D471/08 ,  C07D471/10 ,  C07D491/10

摘要： Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, X, and n are as defined for Formula (I) in the description, processes for the preparation of the compounds and new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and the use of the compounds in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction.