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1.发明公开OXADIAZOLE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS - 842 有权恶二唑衍生物及其作为增效剂对METABO谷氨酸受体 - 842
公开(公告)号：EP2167502A1
公开(公告)日：2010-03-31
申请号：EP08779348.5
申请日：2008-06-05
申请人： AstraZeneca AB
发明人： CLAYTON, Joshua , EGLE, Ian , EMPFIELD, James , FOLMER, James , ISAAC, Methvin , MA, Fupeng , SLASSI, Abdelmalik
IPC分类号： C07D413/14 , A61K31/496 , A61P25/00
CPC分类号： C07D413/04 , C07D413/14 , C07D487/08
摘要： Compounds of Formula (I) wherein R1 and Q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
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2.发明授权SUBSTITUTED BENZOSULPHONAMIDES AS POTENTIATORS OF GLUTAMATE RECEPTORS 有权SUBSTITUIRTE BENZOSULFONAMIDE谷氨酸受体的增效
公开(公告)号：EP1615904B1
公开(公告)日：2008-02-27
申请号：EP04750131.7
申请日：2004-04-15
申请人： AstraZeneca AB
发明人： EGLE, Ian , FREY, Jennifer , ISAAC, Methvin , SLASSI, Abdelmalik , SUN, Gaung ri , FIELD, Johnathan Wesley
IPC分类号： C07D311/16
CPC分类号： C07D209/08 , C07D213/50 , C07D213/75 , C07D215/12 , C07D233/64 , C07D241/12 , C07D295/26 , C07D333/68 , C07D413/04 , C07D471/04
摘要： The present invention provides novel compounds of formula I that function as potentiators of glutamate receptors, methods for their preparation, pharmaceutical compositions containing them, and methods of their use in therapy.
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3.发明授权OXADIAZOLE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS - 842 有权恶二唑衍生物及其作为增效剂对METABO谷氨酸受体 - 842
公开(公告)号：EP2167502B3
公开(公告)日：2013-07-10
申请号：EP08779348.5
申请日：2008-06-05
申请人： AstraZeneca AB
发明人： CLAYTON, Joshua , EGLE, Ian , EMPFIELD, James , FOLMER, James , ISAAC, Methvin , MA, Fupeng , SLASSI, Abdelmalik
IPC分类号： C07D487/08 , C07D413/04
CPC分类号： C07D413/04 , C07D413/14 , C07D487/08
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4.发明公开TRICYCLIC BENZIMIDAZOLES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS 审中-公开三环苯并咪唑和它们作为调节剂的代谢型谷氨酸受体
公开(公告)号：EP1912989A2
公开(公告)日：2008-04-23
申请号：EP06787957.7
申请日：2006-07-21
申请人： AstraZeneca AB
发明人： ISAAC, Methvin , SLASSI, Abdelmalik , EGLE, Ian , MA, Fupeng
IPC分类号： C07D471/06 , C07D498/06 , C07D487/06 , A61P25/00 , A61K31/437
CPC分类号： C07D487/06 , C07D471/06 , Y02P20/582
摘要： The invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein R1, R2, R3, A, B, D, m, n, x, and y are defined as described in the specification. The invention additionally provides a pharmaceutically composition comprising the compound of formula (I), together with a method of using the same to treat or prevent neurological and psychiatric disorders. The compounds are useful in therapy related to the treatment or prevention of mGluR2 receptor-mediated disorders.
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5.发明授权OXADIAZOLE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS - 842 有权恶二唑衍生物及其作为增效剂对METABO谷氨酸受体 - 842
公开(公告)号：EP2167502B1
公开(公告)日：2012-09-19
申请号：EP08779348.5
申请日：2008-06-05
申请人： AstraZeneca AB
发明人： CLAYTON, Joshua , EGLE, Ian , EMPFIELD, James , FOLMER, James , ISAAC, Methvin , MA, Fupeng , SLASSI, Abdelmalik
IPC分类号： C07D487/08 , C07D413/04
CPC分类号： C07D413/04 , C07D413/14 , C07D487/08
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6.发明公开5-PHENYL-3-BENZYL-OXAZOLIDIN-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS 审中-公开5-苯基-3-苄基恶唑烷-2-酮用于治疗神经和精神疾病的衍生物和相关化合物，热带METABO型谷氨酸受体增效剂
公开(公告)号：EP1994016A2
公开(公告)日：2008-11-26
申请号：EP06838983.2
申请日：2006-12-06
申请人： AstraZeneca AB
发明人： SLASSI, Abdelmalik , JOSEPH, Babu , MA, Fupeng , EGLE, Ian , CLAYTON, Joshua , ISAAC, Methvin , SWIERCZEK, Krysztof
IPC分类号： C07D263/14 , C07D413/12 , A61K31/421 , A61K31/422
CPC分类号： C07D413/08 , C07D263/20 , C07D413/12
摘要： The present invention is directed to compounds of Formula I: Wherein R1, R2, Y, m and n are further defined in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds as metabotropic glutamate receptor potentiators for the treatment of neurological and psychiatric disorders.
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7.发明公开SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS 审中-公开取代的吲哚酮及其用作代谢型谷氨酸受体增强物质
公开(公告)号：EP1912940A1
公开(公告)日：2008-04-23
申请号：EP06720759.7
申请日：2006-02-15
申请人： AstraZeneca AB
发明人： VAN WAGENEN, Bradford , UKKIRAMAPANDIAN, Radhakrishnan , CLAYTON, Joshua , EGLE, Ian , EMPFIELD, James , ISAAC, Methvin , MA, Fupeng , SLASSI, Abdelmalik , STEELMAN, Gary , URBANEK, Rebecca , WALSH, Sally
IPC分类号： C07D209/46 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D413/04 , C07D413/14 , A61K31/4245 , A61K31/4439 , A61K31/4035 , A61K31/506 , A61P25/00
CPC分类号： C07D401/04 , C07D209/46 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： The present invention is directed to compounds of formula (I), wherein R1 is a ring, R5 is a specified substituent, and n is from 1 to 8. The invention also relates to the use of the compounds in therapy as metabotropic glutamate receptors modulators, particularly in neurological and psychiatric disorders.
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8.发明公开SUBSTITUTED BENZOSULPHONAMIDE AS POTENTIATORS OF GLUTAMATE RECEPTORS 有权SUBSTITUIRTE BENZOSULFONAMIDE谷氨酸受体的增效
公开(公告)号：EP1615904A2
公开(公告)日：2006-01-18
申请号：EP04750131.7
申请日：2004-04-15
发明人： EGLE, Ian , FREY, Jennifer , ISAAC, Methvin , SLASSI, Abdelmalik , SUN, Gaung ri , FIELD, Johnathan Wesley
IPC分类号： C07D311/16
CPC分类号： C07D209/08 , C07D213/50 , C07D213/75 , C07D215/12 , C07D233/64 , C07D241/12 , C07D295/26 , C07D333/68 , C07D413/04 , C07D471/04
摘要： The present invention provides novel compounds of formula I that function as potentiators of glutamate receptors, methods for their preparation, pharmaceutical compositions containing them, and methods of their use in therapy.
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9.发明公开BICYCLIC BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS 审中-公开双环苯并咪唑化合物及其作为受体AMPLIFIER谷氨酸METABOTROPEM作者使用
公开(公告)号：EP2004613A2
公开(公告)日：2008-12-24
申请号：EP07759672.4
申请日：2007-03-29
申请人： AstraZeneca AB
发明人： EGLE, Ian , ISAAC, Methvin , URBANEK, Rebecca , MCLAREN, Frances M. , WALSH, Sally B. , STEELMAN, Gary B. , BROWN, Dean G. , NUGIEL, David , CHEN, Deborah W. , SLASSI, Abdelmalik , MA, Fupeng
IPC分类号： C07D235/06 , C07D403/12 , C07D235/14 , C07D401/06 , C07D401/14 , C07D403/06 , A61K31/4184 , A61P25/28 , A61P25/30
CPC分类号： C07D401/06 , C07D235/06 , C07D235/14 , C07D401/14 , C07D403/06 , C07D403/12
摘要： Compounds of Formula (I): Formula (I) wherein A, B, D, L, R1, R2, R3, R4, m, and n are as defined for Formula (I) in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
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公开(公告)号：EP1986998A1
公开(公告)日：2008-11-05
申请号：EP07717216.1
申请日：2007-02-06
申请人： AstraZeneca AB
发明人： EMPFIELD, James R. , FOLMER, James J. , EGLE, Ian , CLAYTON, Joshua , SLASSI, Abelmalik , MA, Fupeng , ARNOLD, James, R. , ISAAC, Methvin
IPC分类号： C07D209/46 , C07D401/04 , A61K31/4035 , A61K31/4406 , A61P25/00
CPC分类号： C07D209/46 , C07D401/04 , C07D405/04
摘要： Compounds of Formula (I): wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the description, processes for the preparing such compounds, new intermediates employed in their preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.
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