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1.发明公开SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS 审中-公开取代的吲哚酮及其用作代谢型谷氨酸受体增强物质
公开(公告)号：EP1912940A1
公开(公告)日：2008-04-23
申请号：EP06720759.7
申请日：2006-02-15
申请人： AstraZeneca AB
发明人： VAN WAGENEN, Bradford , UKKIRAMAPANDIAN, Radhakrishnan , CLAYTON, Joshua , EGLE, Ian , EMPFIELD, James , ISAAC, Methvin , MA, Fupeng , SLASSI, Abdelmalik , STEELMAN, Gary , URBANEK, Rebecca , WALSH, Sally
IPC分类号： C07D209/46 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D413/04 , C07D413/14 , A61K31/4245 , A61K31/4439 , A61K31/4035 , A61K31/506 , A61P25/00
CPC分类号： C07D401/04 , C07D209/46 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： The present invention is directed to compounds of formula (I), wherein R1 is a ring, R5 is a specified substituent, and n is from 1 to 8. The invention also relates to the use of the compounds in therapy as metabotropic glutamate receptors modulators, particularly in neurological and psychiatric disorders.
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公开(公告)号：EP1912939A1
公开(公告)日：2008-04-23
申请号：EP06720758.9
申请日：2006-02-15
申请人： AstraZeneca AB
发明人： VAN WAGENEN, Bradford , UKKIRAMAPANDIAN, Radhakrishnan , CLAYTON, Joshua , EGLE, Ian , EMPFIELD, James , ISAAC, Methvin , MA, Fupeng , SLASSI, Abdelmalik , STEELMAN, Gary , URBANEK, Rebecca , WALSH, Sally
IPC分类号： C07D209/46 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04 , A61K31/497 , A61K31/4439 , A61K31/4035 , A61P25/00
CPC分类号： C07D401/04 , C07D209/46 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： Compounds of formula (I), wherein R1 is a ring , and uses of the compounds in therapy as metabotropic glutamate receptors modulators, particularly in neurological and psychiatric disorders.
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