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1.发明公开PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS 审中-公开吡唑啉酮谷氨酸受体激动剂的神经和精神疾病的治疗代谢
公开(公告)号：EP1833800A1
公开(公告)日：2007-09-19
申请号：EP05855204.3
申请日：2005-12-22
发明人： BALESTRA, Michael, c/o AstraZeneca Wilmington , BUNTING, Heather, c/o AstraZeneca Wilmington , CHEN, Deborah, c/o GlaxoSmithKline N&GI CEDD , EGLE, Ian , FORST, Janet, AstraZeneca Wilmington , FREY, Jennifer , ISAAC, Methvin , MA, Fupeng , NUGIEL, David, c/o AstraZeneca Wilmington , SLASSI, Abdelmalik , STEELMAN, Gary, c/o AstraZeneca Wilmington , SUN, Guang-ri , SUNDAR, Babu, c/o AstraZeneca Wilmington , UKKIRAMAPANDIAN, Radhakrishnan , URBANEK, Rebecca A., c/o AstraZeneca Wilmigton , WALSH, Sally, c/o AstraZeneca Wilmington
IPC分类号： C07D231/22 , C07D231/20 , A61P25/28
CPC分类号： C07D401/14 , C07D211/62 , C07D231/22 , C07D401/06 , C07D401/12 , C07D403/06 , C07D413/14 , C07D417/12 , C07D471/08 , C07D471/10 , C07D491/10
摘要： Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, X, and n are as defined for Formula (I) in the description, processes for the preparation of the compounds and new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and the use of the compounds in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction.
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2.发明公开SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS 审中-公开取代的吲哚酮及其用作代谢型谷氨酸受体增强物质
公开(公告)号：EP1912940A1
公开(公告)日：2008-04-23
申请号：EP06720759.7
申请日：2006-02-15
申请人： AstraZeneca AB
发明人： VAN WAGENEN, Bradford , UKKIRAMAPANDIAN, Radhakrishnan , CLAYTON, Joshua , EGLE, Ian , EMPFIELD, James , ISAAC, Methvin , MA, Fupeng , SLASSI, Abdelmalik , STEELMAN, Gary , URBANEK, Rebecca , WALSH, Sally
IPC分类号： C07D209/46 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D413/04 , C07D413/14 , A61K31/4245 , A61K31/4439 , A61K31/4035 , A61K31/506 , A61P25/00
CPC分类号： C07D401/04 , C07D209/46 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： The present invention is directed to compounds of formula (I), wherein R1 is a ring, R5 is a specified substituent, and n is from 1 to 8. The invention also relates to the use of the compounds in therapy as metabotropic glutamate receptors modulators, particularly in neurological and psychiatric disorders.
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公开(公告)号：EP1912939A1
公开(公告)日：2008-04-23
申请号：EP06720758.9
申请日：2006-02-15
申请人： AstraZeneca AB
发明人： VAN WAGENEN, Bradford , UKKIRAMAPANDIAN, Radhakrishnan , CLAYTON, Joshua , EGLE, Ian , EMPFIELD, James , ISAAC, Methvin , MA, Fupeng , SLASSI, Abdelmalik , STEELMAN, Gary , URBANEK, Rebecca , WALSH, Sally
IPC分类号： C07D209/46 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04 , A61K31/497 , A61K31/4439 , A61K31/4035 , A61P25/00
CPC分类号： C07D401/04 , C07D209/46 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： Compounds of formula (I), wherein R1 is a ring , and uses of the compounds in therapy as metabotropic glutamate receptors modulators, particularly in neurological and psychiatric disorders.
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