公开(公告)号：EP2571930A1

公开(公告)日：2013-03-27

申请号：EP11720526.0

申请日：2011-05-20

Applicant: BASF SE

Inventor： SANDLER, Jan, Kurt, Walter ,  BELLIN, Ingo ,  DJURIC, Dejan ,  KOLTER, Karl ,  RUCKDÄSCHEL, Holger

IPC: C08J9/12 ,  C08J9/00 ,  A61K9/12

CPC classification number: C08J9/122 ,  A61K9/122 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1694 ,  C08J9/0014 ,  C08J9/0071 ,  C08J2207/10

Abstract: The invention relates to a method for producing nanoporous foamed, active ingredient-containing preparations, in which the active ingredient is present embedded in a pharmaceutically acceptable polymer, characterized in that in stage a) a polymeric molding compound or a polymer melt is loaded with an expanding agent at a pressure and a temperature at which the expanding agent is in the supercritical state, in stage b) a temperature of the loaded polymeric molding compound or melt is controlled to a temperature which is in the range from -40 to +60ºC, preferably from -20 to +55ºC, and still more preferably from 0 to +50ºC around the glass transition temperature of the unloaded polymeric molding compound, and in stage c) the polymeric molding compound or melt, which has been loaded in stage a) and the temperature of which has been controlled under pressure in stage b), is depressurized at a depressurization rate in the range from 15,000 to 200,000 MPa/sec.

公开(公告)号：EP2164461B1

公开(公告)日：2013-01-23

申请号：EP08760353.6

申请日：2008-06-02

Applicant: BASF SE

Inventor： KOLTER, Karl ,  SCHÖNHERR, Michael ,  GEBERT, Silke ,  MEYER-BÖHM, Kathrin ,  MASCHKE, Angelika

IPC: A61K47/32 ,  A61K9/00 ,  A61K9/20 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38

CPC classification number: A61K9/0056 ,  A61K9/2018 ,  A61K9/2027

公开(公告)号：EP2477593A1

公开(公告)日：2012-07-25

申请号：EP10752340.9

申请日：2010-09-07

Applicant: BASF SE

Inventor： KOLTER, Karl ,  DJURIC, Dejan ,  FISCHER, Stefan

IPC: A61J3/00 ,  A61K9/14 ,  B29C45/00 ,  C08J3/22

CPC classification number: C08J3/226 ,  A61K9/2095 ,  B29C45/0001 ,  C08J2451/00

Abstract: The invention relates to a method for producing molded parts from preparations of active substances with low solubility in water, the active substances being present embedded in amphiphilic copolymers, characterized in that the molding of the preparations takes place by means of injection molding a melt of the preparations, wherein the molding temperature of the melt is 40 to 180°C.

公开(公告)号：EP2437734A2

公开(公告)日：2012-04-11

申请号：EP10724415.4

申请日：2010-05-31

Applicant: BASF SE

Inventor： KOLTER, Karl ,  ANGEL, Maximilian

IPC: A61K9/32

CPC classification number: A61K9/0056 ,  A61K9/2081 ,  A61K9/5073 ,  A61K47/32

Abstract: The invention relates to orally disintegrating dosage forms of taste-masked active ingredients, which are provided with a coating of polymers containing N,N-diethylaminoethylmethacrylate (DEAEMA) that is polymerized therein for masking the taste, and in which the taste-masked active ingredients are embedded in an orally disintegrating matrix.

公开(公告)号：EP2114375B1

公开(公告)日：2011-11-30

申请号：EP07857369.8

申请日：2007-12-11

Applicant: BASF SE

Inventor： KOLTER, Karl ,  MASCHKE, Angelika ,  DIETZEN, Franz-Josef ,  SCHMELLER, Thorsten

IPC: A61K9/28 ,  A61K9/14

CPC classification number: A61K9/284

Abstract: The invention relates to solid particulate film coating agents consisting of: a) 40 - 90 % by weight, preferably 40 - 70 % by weight polyvinyl alcohol-polyether graft copolymers (component A), b) up to 60 % by weight, preferably between 20 and 45 % by weight of a coloured or achromatic colouring agent (component B), c) between 0 and 30 % by weight additional conventional auxiliary agents (component C). According to the invention, the quantities of components A to C total 100 % by weight. Said coating agents are obtained by the extrusion of a plastic mass of components A) to C) and by a subsequent shaping process.

公开(公告)号：EP2170273A2

公开(公告)日：2010-04-07

申请号：EP08760352.8

申请日：2008-06-02

Applicant: BASF SE

Inventor： KOLTER, Karl ,  SCHÖNHERR, Michael ,  GEBERT, Silke ,  MEYER-BÖHM, Kathrin ,  MASCHKE, Angelika

IPC: A61K9/00 ,  A61K9/20 ,  A61K9/16

CPC classification number: A61K9/0056 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054

Abstract: The invention relates to a pharmaceutical formulation in the form of compacts containing a) 60 - 97 % by weight of sugar or sugar alcohols, b) 1 - 25 % by weight of a disintegration agent selected from the group consisting of croscarmellose, sodium carboxymethyl starch and L-hydroxypropyl cellulose, c) 1 - 15 % by weight of water insoluble film-forming polymers, d) 0 - 15 % by weight of water-soluble polymers, and e) 0 - 15 % by weight of additional conventional pharmaceutical adjuvants, the sum of the components a) to e) totalling 100 % by weight.

Abstract translation: 本发明涉及压制物形式的药物制剂，其含有a）60-97重量％的糖或糖醇，b）1-25重量％的崩解剂，其选自交联羧甲基纤维素，羧甲基淀粉钠 和L-羟丙基纤维素，c）1-15重量％的水不溶性成膜聚合物，d）0-15重量％的水溶性聚合物，和e）0-15重量％的另外的常规药物佐剂 ，组分a）至e）的总和为总计100重量％。

公开(公告)号：EP2114375A1

公开(公告)日：2009-11-11

申请号：EP07857369.8

申请日：2007-12-11

Applicant: BASF SE

Inventor： KOLTER, Karl ,  MASCHKE, Angelika ,  DIETZEN, Franz-Josef ,  SCHMELLER, Thorsten

IPC: A61K9/14

CPC classification number: A61K9/284

Abstract: The invention relates to solid particulate film coating agents consisting of: a) 40 - 90 % by weight, preferably 40 - 70 % by weight polyvinyl alcohol-polyether graft copolymers (component A), b) up to 60 % by weight, preferably between 20 and 45 % by weight of a coloured or achromatic colouring agent (component B), c) between 0 and 30 % by weight additional conventional auxiliary agents (component C). According to the invention, the quantities of components A to C total 100 % by weight. Said coating agents are obtained by the extrusion of a plastic mass of components A) to C) and by a subsequent shaping process.

公开(公告)号：EP1965761A2

公开(公告)日：2008-09-10

申请号：EP06841327.7

申请日：2006-12-11

Applicant: BASF SE

Inventor： KOLTER, Karl ,  WICHTNER, Marcus ,  SCHÖNHERR, Michael ,  MITTWOLLEN, Jan-Peter

IPC: A61K9/00 ,  A61K9/20

CPC classification number: A61K9/0056 ,  A61K9/2018

Abstract: The invention relates to a pharmaceutical formulation in the form of agglomerates containing a) 60 - 97 % by weight of sugar or sugar alcohols, b) 1 - 25 % by weight of cross-linked polyvinylpyrrolidone, c) 1 - 15 % by weight of water-insoluble, film-forming polymers, d) 0 - 15 % by weight of water-soluble polymers, and e) 0 - 15 % by weight of other pharmaceutically suitable adjuvants, the sum of components a) to e) adding up to 100 % by weight.

公开(公告)号：EP1926480A2

公开(公告)日：2008-06-04

申请号：EP06793103.0

申请日：2006-08-31

Applicant: BASF SE

Inventor： KOLTER, Karl ,  MITTWOLLEN, Jan-Peter ,  SCHILLO, Simone ,  MEYER-BÖHM, Kathrin ,  ANGEL, Maximilian

IPC: A61K9/48

CPC classification number: A61K9/4816 ,  B29C47/0021 ,  B29C47/786 ,  B29C47/822 ,  B29C47/8845 ,  C11D17/0039

Abstract: Disclosed is a method for producing gelatin-free soft capsule envelopes based on polyvinyl alcohol-polyether graft polymers as enveloping polymers. Said method is characterized in that an aqueous solution containing at least 45 percent by weight of a polymer component which comprises a polyvinyl alcohol-polyether graft polymer or a mixture of polyvinyl alcohol-polyether graft polymers and polyvinyl alcohol is heated, the percentage being in relation to the total weight of the solution, the solution is extruded at a minimum temperature of 70 °C, and the obtained film is solidified by cooling.

公开(公告)号：EP3793526A1

公开(公告)日：2021-03-24

申请号：EP19723427.1

申请日：2019-05-15

Applicant: BASF SE

Inventor： SMIT, Theo ,  KARL, Matthias ,  GUTH, Felicitas ,  ANGEL, Maximilian ,  KOLTER, Karl ,  SCHMIDT, Frank ,  BLOCHBERGER-CLAUS, Maximilian

IPC: A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  C11C3/00