-
公开(公告)号：EP2858993B1
公开(公告)日：2018-01-10
申请号：EP13712778.3
申请日：2013-03-27
发明人： EIS, Knut , PÜHLER, Florian , ZORN, Ludwig , SCHULZE, Volker , SÜLZLE, Detlev , LIENAU, Philip , HÄGEBARTH, Andrea , PETERSEN, Kirstin , BÖMER, Ulf
IPC分类号： A61K31/5025 , A61K31/5377 , C07D487/04
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/5377
摘要： The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I), in which A, R1, R2, R3, R4, R5 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
-
12.发明授权SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. 有权用作BUB1激酶抑制剂用于治疗过度增殖性疾病的取代苯并噻唑类化合物。
公开(公告)号：EP2763982B1
公开(公告)日：2018-01-10
申请号：EP12766997.6
申请日：2012-10-04
发明人： HITCHCOCK, Marion , MENGEL, Anne , PÜTTER, Vera , SIEMEISTER, Gerhard , WENGNER, Antje Margret , BRIEM, Hans , EIS, Knut , SCHULZE, Volker , FERNANDEZ-MONTALVAN, Amaury Ernesto , PRECHTL, Stefan , HOLTON, Simon , FANGHÄNEL, Jörg , LIENAU, Philip , PREUSSE, Cornelia , GNOTH, Mark Jean
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D498/04 , A61K31/506 , A61P35/00
CPC分类号： C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14
摘要： Compounds of formula (1) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
-
公开(公告)号：EP2507236B1
公开(公告)日：2014-12-17
申请号：EP10787724.3
申请日：2010-11-26
发明人： KOPPITZ, Marcus , SCHULZE, Volker , KOSEMUND, Dirk , SCHIROK, Hartmut , BADER, Benjamin , LIENAU, Philipp , MARQUARDT, Tobias , WEGSCHEIDT-GERLACH, Christof , SIEMEISTER, Gerhard , PRECHTL, Stefan , WENGNER, Antje, Margret , BÖMER, Ulf
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/282 , A61K31/337 , A61K31/427 , A61K31/437 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/565 , A61K31/573 , A61K31/664 , A61K31/704 , A61K31/7076 , A61K33/24 , A61K39/3955
-
14.发明公开SUBSTITUTED TRIAZOLOPYRIDINES AND THEIR USE AS TTK INHIBITORS 有权替代品TRIZOLOPYRIDINE UND IHRE VERWENDUNG ALS TTK-INHIBITOREN
公开(公告)号：EP2791136A1
公开(公告)日：2014-10-22
申请号：EP12805516.7
申请日：2012-12-10
发明人： SCHULZE, Volker , KOSEMUND, Dirk , WENGNER, Antje Margret , SIEMEISTER, Gerhard , STÖCKIGT, Detlef , BRUENING, Michael
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/7028 , A61K45/06
摘要： The present invention relates to substituted triazolopyndine compounds of general formula (I) : in which R
1 , R
2 , R
3 , R
4 , and R
5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.摘要翻译： 本发明涉及通式（I）的取代三唑并吡啶化合物：其中R 1，R 2，R 3，R 4和R 5如说明书和权利要求书中所述，涉及制备所述化合物的方法，药物组合物和组合 包括所述化合物，所述化合物用于制备用于治疗或预防疾病的药物组合物，以及可用于制备所述化合物的中间体化合物。
-
公开(公告)号：EP2507235B1
公开(公告)日：2014-10-22
申请号：EP10787274.9
申请日：2010-11-17
发明人： SCHULZE, Volker , KOPPITZ, Marcus , KOSEMUND, Dirk , SCHIROK, Hartmut , BADER, Benjamin , LIENAU, Philip , WENGNER, Antje, Margret , BRIEM, Hans , HOLTON, Simon , SIEMEISTER, Gerhard , PRECHTL, Stefan , BÖMER, Ulf
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/5377 , A61K2300/00
-
公开(公告)号：EP2699575A1
公开(公告)日：2014-02-26
申请号：EP12721779.2
申请日：2012-04-16
发明人： SCHULZE, Volker , KOSEMUND, Dirk , WENGNER, Antje, Margret , SIEMEISTER, Gerhard , STÖCKIGT, Detlef , LIENAU, Philip , SCHIROK, Hartmut , BRIEM, Hans
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： The present invention relates to triazolopyridine compounds of general formula (I) : in which R
1 , R
2 , R
3 , R
4 , and R
5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.-
公开(公告)号：EP2507233B1
公开(公告)日：2013-11-06
申请号：EP10782198.5
申请日：2010-11-17
发明人： SCHULZE, Volker , KOPPITZ, Marcus , KOSEMUND, Dirk , BADER, Benjamin , LIENAU, Philip , BRIEM, Hans , HOLTON, Simon , SIEMEISTER, Gerhard , PRECHTL, Stefan , WENGNER, Antje, Margret
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.039 秒)
