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公开(公告)号：EP2699554B1
公开(公告)日：2016-11-02
申请号：EP12714336.0
申请日：2012-04-18
发明人： LÜCKING, Ulrich , BOHLMANN, Rolf , SCHOLZ, Arne , SIEMEISTER, Gerhard , GNOTH, Mark, Jean , BÖMER, Ulf , RÜHTER, Gerd , SCHULZ-FADEMRECHT, Carsten , KOSEMUND, Dirk , LIENAU, Philip
IPC分类号： C07D401/12 , C07D405/04 , C07D251/42 , C07D401/04 , C07D405/12
CPC分类号： C07D251/42 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12
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2.发明公开SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. 有权SUBSTITUIERTE BENZYLINDAZOLE ZUR VERWENDUNG ALS BUB1-KINASEHEMMER BEI DER BEHANDLUNG HYPERPROLIFERATIVER ERKRANKUNGEN
公开(公告)号：EP2763982A1
公开(公告)日：2014-08-13
申请号：EP12766997.6
申请日：2012-10-04
发明人： HITCHCOCK, Marion , MENGEL, Anne , PÜTTER, Vera , SIEMEISTER, Gerhard , WENGNER, Antje Margret , BRIEM, Hans , EIS, Knut , SCHULZE, Volker , FERNANDEZ-MONTALVAN, Amaury Ernesto , PRECHTL, Stefan , HOLTON, Simon , FANGHÄNEL, Jörg , LIENAU, Philip , PREUSSE, Cornelia , GNOTH, Mark Jean
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D498/04 , A61K31/506 , A61P35/00
CPC分类号： C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14
摘要： Compounds of formula (1) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，其制备方法及其作为药物的用途。
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公开(公告)号：EP2699554A1
公开(公告)日：2014-02-26
申请号：EP12714336.0
申请日：2012-04-18
发明人： LÜCKING, Ulrich , BOHLMANN, Rolf , SCHOLZ, Arne , SIEMEISTER, Gerhard , GNOTH, Mark, Jean , BÖMER, Ulf , RÜHTER, Gerd , SCHULZ-FADEMRECHT, Carsten , KOSEMUND, Dirk , LIENAU, Philip
IPC分类号： C07D251/12 , C07D401/04 , C07D405/10 , C07D405/12 , A61K31/497 , A61P35/00
CPC分类号： C07D251/42 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12
摘要： The present invention relates to substituted 4-Aryl-N-phenyl-1,3,5-triazin-2-amines of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
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4.发明授权SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. 有权用作BUB1激酶抑制剂用于治疗过度增殖性疾病的取代苯并噻唑类化合物。
公开(公告)号：EP2763982B1
公开(公告)日：2018-01-10
申请号：EP12766997.6
申请日：2012-10-04
发明人： HITCHCOCK, Marion , MENGEL, Anne , PÜTTER, Vera , SIEMEISTER, Gerhard , WENGNER, Antje Margret , BRIEM, Hans , EIS, Knut , SCHULZE, Volker , FERNANDEZ-MONTALVAN, Amaury Ernesto , PRECHTL, Stefan , HOLTON, Simon , FANGHÄNEL, Jörg , LIENAU, Philip , PREUSSE, Cornelia , GNOTH, Mark Jean
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D498/04 , A61K31/506 , A61P35/00
CPC分类号： C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14
摘要： Compounds of formula (1) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号：EP2547680B1
公开(公告)日：2015-08-05
申请号：EP11708301.4
申请日：2011-03-16
发明人： KLAR, Ulrich , KOPPITZ, Marcus , KOSEMUND, Dirk , BOHLMANN, Rolf , BADER, Benjamin , LIENAU, Philip , SIEMEISTER, Gerhard , PRECHTL, Stefan , NGUYEN, Duy , SCOTT, William
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00
CPC分类号： A61K31/519 , A61K45/06 , C07D487/04 , C07D487/14
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公开(公告)号：EP2758401A1
公开(公告)日：2014-07-30
申请号：EP12761564.9
申请日：2012-09-05
发明人： EIS, Knut , PÜHLER, Florian , ZORN, Ludwig , SCHOLZ, Arne , LIENAU, Philip , GNOTH, Mark, Jean , BÖMER, Ulf , GÜNTHER, Judith , HITCHCOCK, Marion
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/5377 , A61K45/06
摘要： The present invention relates to amino-substituted imidazopyridazine compounds of general formula(I): in which A, R1, R3 and n are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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7.发明公开DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP 有权WITH A亚磺酰亚胺二取代5- FLUOR-嘧啶衍生物
公开(公告)号：EP2755948A1
公开(公告)日：2014-07-23
申请号：EP12758496.9
申请日：2012-09-13
发明人： LÜCKING, Ulrich , KOSEMUND, Dirk , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , BOHLMANN, Rolf
IPC分类号： C07C381/10 , C07D239/42 , C07D405/04 , A61K31/505 , A61P9/00 , A61P31/12 , A61P35/00
CPC分类号： C07D405/04 , A61K31/505 , A61K31/506 , C07C381/10 , C07D239/42
摘要： The present invention relates to disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
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8.发明公开4-ARYL-N-PHENYL-1,3,5-TRIAZIN-2-AMINES CONTAINING A SULFOXIMINE GROUP 有权具有磺基肟4-芳基-N-苯基-1,3,5-三嗪-2-胺
公开(公告)号：EP2714654A1
公开(公告)日：2014-04-09
申请号：EP12721558.0
申请日：2012-05-21
发明人： LÜCKING, Ulrich , BOHLMANN, Rolf , SCHOLZ, Arne , SIEMEISTER, Gerhard , GNOTH, Mark, Jean , BÖMER, Ulf , KOSEMUND, Dirk , LIENAU, Philip , RÜHTER, Gerd , SCHULZ-FADEMRECHT, Carsten
IPC分类号： C07C311/13 , C07D251/16 , C07D251/22 , A61K31/53 , A61P9/00 , A61P31/00 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12
CPC分类号： A61K31/53 , C07B59/002 , C07B2200/05 , C07C381/10 , C07D251/16 , C07D251/22 , C07D251/42 , C07D251/44 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I) or (Ia).
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9.发明授权DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP 有权WITH A亚磺酰亚胺二取代5- FLUOR-嘧啶衍生物
公开(公告)号：EP2755948B1
公开(公告)日：2016-05-25
申请号：EP12758496.9
申请日：2012-09-13
发明人： LÜCKING, Ulrich , KOSEMUND, Dirk , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , BOHLMANN, Rolf
IPC分类号： C07C381/10 , C07D239/42 , C07D405/04 , A61K31/505 , A61P9/00 , A61P31/12 , A61P35/00
CPC分类号： C07D405/04 , A61K31/505 , A61K31/506 , C07C381/10 , C07D239/42
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公开(公告)号：EP2858993A1
公开(公告)日：2015-04-15
申请号：EP13712778.3
申请日：2013-03-27
发明人： EIS, Knut , PÜHLER, Florian , ZORN, Ludwig , SCHULZE, Volker , SÜLZLE, Detlev , LIENAU, Philip , HÄGEBARTH, Andrea , PETERSEN, Kirstin , BÖMER, Ulf
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/5377
摘要： The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I), in which A, R1, R2, R3, R4, R5 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的氨基取代的咪唑并哒嗪化合物，其中A，R 1，R 2，R 3，R 4，R 5和n如权利要求中所定义，涉及制备所述化合物的方法， 用于制备所述化合物的药物组合物和包含所述化合物的组合物以及所述化合物用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物作为唯一的用途 药剂或与其他活性成分组合。
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