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    AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES
    5.
    发明公开
    AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES 有权
    氨基磺酰胺咪唑吡嗪

    公开(公告)号：EP2858993A1

    公开(公告)日：2015-04-15

    申请号：EP13712778.3

    申请日：2013-03-27

    申请人： Bayer Intellectual Property GmbH

    发明人： EIS, Knut ,  PÜHLER, Florian ,  ZORN, Ludwig ,  SCHULZE, Volker ,  SÜLZLE, Detlev ,  LIENAU, Philip ,  HÄGEBARTH, Andrea ,  PETERSEN, Kirstin ,  BÖMER, Ulf

    IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00

    CPC分类号： C07D487/04 ,  A61K31/5025 ,  A61K31/5377

    摘要： The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I), in which A, R1, R2, R3, R4, R5 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

    摘要翻译： 本发明涉及通式（I）的氨基取代的咪唑并哒嗪化合物，其中A，R 1，R 2，R 3，R 4，R 5和n如权利要求中所定义，涉及制备所述化合物的方法， 用于制备所述化合物的药物组合物和包含所述化合物的组合物以及所述化合物用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物作为唯一的用途 药剂或与其他活性成分组合。

    AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES
    10.
    发明公开
    AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES 有权
    氨基磺酰胺咪唑吡嗪

    公开(公告)号：EP2804864A1

    公开(公告)日：2014-11-26

    申请号：EP12806400.3

    申请日：2012-12-10

    申请人： Bayer Intellectual Property GmbH

    发明人： EIS, Knut ,  PÜHLER, Florian ,  ZORN, Ludwig ,  LIENAU, Philip ,  SUELZLE, Detlev ,  HÄGEBARTH, Andrea ,  BÖMER, Ulf ,  PETERSEN, Kirstin ,  SCHULZE, Volker

    IPC分类号： C07D491/048 ,  A61K31/5025 ,  A61P35/00

    CPC分类号： C07D491/048 ,  A61K31/5025 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to amino-substituted imidazopyndazine compounds of general formula (I) : in which A, R1, R2, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

    摘要翻译： 本发明涉及通式（I）的氨基取代的咪唑并二嗪化合物：其中A，R 1，R 2，R 3，R 4和n如权利要求中所定义，涉及制备所述化合物的方法，可用于制备 所述化合物，包含所述化合物的药物组合物和组合以及所述化合物用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物作为唯一试剂的用途或 与其他活性成分组合。