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公开(公告)号：EP2794596B1
公开(公告)日：2017-05-31
申请号：EP12808361.5
申请日：2012-12-17
发明人： HITCHCOCK, Marion , MENGEL, Anne , RICHTER, Anja , BRIEM, Hans , EIS, Knut , PÜTTER, Vera , SIEMEISTER, Gerhard , PRECHTL, Stefan , FERNÁNDEZ-MONTALVÁN, Amaury Ernesto , STEGMANN, Christian , HOLTON, Simon , GNOTH, Mark Jean , PREUSSE, Cornelia
IPC分类号： C07D401/14 , A61K31/4155 , A61P35/00
CPC分类号： C07D401/14 , A61K31/506 , C07D405/14
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2.发明公开SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. 有权SUBSTITUIERTE BENZYLINDAZOLE ZUR VERWENDUNG ALS BUB1-KINASEHEMMER BEI DER BEHANDLUNG HYPERPROLIFERATIVER ERKRANKUNGEN
公开(公告)号：EP2763982A1
公开(公告)日：2014-08-13
申请号：EP12766997.6
申请日：2012-10-04
发明人： HITCHCOCK, Marion , MENGEL, Anne , PÜTTER, Vera , SIEMEISTER, Gerhard , WENGNER, Antje Margret , BRIEM, Hans , EIS, Knut , SCHULZE, Volker , FERNANDEZ-MONTALVAN, Amaury Ernesto , PRECHTL, Stefan , HOLTON, Simon , FANGHÄNEL, Jörg , LIENAU, Philip , PREUSSE, Cornelia , GNOTH, Mark Jean
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D498/04 , A61K31/506 , A61P35/00
CPC分类号： C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14
摘要： Compounds of formula (1) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，其制备方法及其作为药物的用途。
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3.发明授权SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. 有权用作BUB1激酶抑制剂用于治疗过度增殖性疾病的取代苯并噻唑类化合物。
公开(公告)号：EP2763982B1
公开(公告)日：2018-01-10
申请号：EP12766997.6
申请日：2012-10-04
发明人： HITCHCOCK, Marion , MENGEL, Anne , PÜTTER, Vera , SIEMEISTER, Gerhard , WENGNER, Antje Margret , BRIEM, Hans , EIS, Knut , SCHULZE, Volker , FERNANDEZ-MONTALVAN, Amaury Ernesto , PRECHTL, Stefan , HOLTON, Simon , FANGHÄNEL, Jörg , LIENAU, Philip , PREUSSE, Cornelia , GNOTH, Mark Jean
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D498/04 , A61K31/506 , A61P35/00
CPC分类号： C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14
摘要： Compounds of formula (1) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号：EP2794596A1
公开(公告)日：2014-10-29
申请号：EP12808361.5
申请日：2012-12-17
发明人： HITCHCOCK, Marion , MENGEL, Anne , RICHTER, Anja , BRIEM, Hans , EIS, Knut , PÜTTER, Vera , SIEMEISTER, Gerhard , PRECHTL, Stefan , FERNÁNDEZ-MONTALVÁN, Amaury Ernesto , STEGMANN, Christian , HOLTON, Simon , GNOTH, Mark Jean , PREUSSE, Cornelia
IPC分类号： C07D401/14 , A61K31/4155 , A61P35/00
CPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
摘要翻译： 式（I）化合物及其作为药物的用途。
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公开(公告)号：EP2714692A1
公开(公告)日：2014-04-09
申请号：EP12729041.9
申请日：2012-05-30
发明人： EIS, Knut , PÜHLER, Florian , ZORN, Ludwig , SCHOLZ, Arne , LIENAU, Philip , GNOTH, Mark Jean , BÖMER, Ulf , GÜNTHER, Judith , FANGHÄNEL, Jörg , KORR, Daniel
IPC分类号： C07D487/04 , C07D519/00 , A61K31/5025 , A61P35/00
CPC分类号： A61K31/5025 , A61K45/06 , C07D487/04 , C07D519/00
摘要： The present invention relates to substituted aminoimidazopyridazine compounds of general formula (I) : in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的取代的氨基咪唑并哒嗪化合物：其中A，R 1，R 2，R 3和R 4如权利要求中所定义，涉及制备所述化合物的方法，药物组合物和包含所述化合物的组合， 所述化合物用于制造用于治疗或预防疾病，特别是过度增殖和/或血管发生病症的药物组合物作为单独药剂或与其他活性成分组合的用途。
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公开(公告)号：EP2714692B1
公开(公告)日：2017-03-22
申请号：EP12729041.9
申请日：2012-05-30
发明人： EIS, Knut , PÜHLER, Florian , ZORN, Ludwig , SCHOLZ, Arne , LIENAU, Philip , GNOTH, Mark Jean , BÖMER, Ulf , GÜNTHER, Judith , FANGHÄNEL, Jörg , KORR, Daniel
IPC分类号： C07D487/04 , C07D519/00 , A61K31/5025 , A61P35/00
CPC分类号： A61K31/5025 , A61K45/06 , C07D487/04 , C07D519/00
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7.发明公开SUBSTITUIERTE BIPIPERIDINYL-DERIVATE ALS ADRENOREZEPTOR ALPHA 2C ANTAGONISTEN 审中-公开取代联哌啶衍生物作为支撑ALPHA 2C受体拮抗剂
公开(公告)号：EP3083594A1
公开(公告)日：2016-10-26
申请号：EP14815662.3
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GNOTH, Mark Jean , HIMMEL, Herbert , KAST, Raimund , KLAR, Jürgen , KNORR, Andreas , LANG, Dieter , LINDNER, Niels , SCHMECK, Carsten , SCHOHE-LOOP, Rudolf , TINEL, Hanna , TRÜBEL, Hubert , WUNDER, Frank
IPC分类号： C07D401/14 , C07D211/16 , C07D211/22 , C07D211/42 , C07D401/12 , C07D403/04 , C07D413/04 , C07D413/10 , C07D413/12 , A61K31/4468 , A61K31/4523 , A61P3/10 , A61P9/00
CPC分类号： C07D211/10 , A61K31/4545 , A61K45/06 , C07D211/16 , C07D211/22 , C07D211/42 , C07D211/60 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, especially for promotion of wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulation disorders, Raynaud phenomena, CREST syndrome, microcirculation disorders, intermittent claudication, and peripheral and autonomous neuropathies.
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公开(公告)号：EP2435427A1
公开(公告)日：2012-04-04
申请号：EP10724697.7
申请日：2010-05-19
发明人： HEIMBACH, Dirk , RÖHRIG, Susanne , CANCHO GRANDE, Yolanda , BENDER, Eckhard , ZIMMERMANN, Katja , BUCHMÜLLER, Anja , GERDES, Christoph , GNOTH, Mark Jean , GERICKE, Kersten Matthias , JESKE, Mario
IPC分类号： C07D413/04 , C07D413/14 , A61K31/4525 , A61K31/4545 , A61K31/4535
CPC分类号： C07D413/04 , C07D413/14
摘要： The invention relates to novel substituted piperidines, to methods for the production thereof, to the use thereof for the treatment and/or prophylaxis of diseases and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases and tumor diseases.
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