公开(公告)号：EP4461354A2

公开(公告)日：2024-11-13

申请号：EP24193389.4

申请日：2010-11-11

申请人： Astellas Pharma Inc. ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  KOSLOWSKI, Michael ,  WALTER, Korden ,  WÖLL, Stefan ,  KREUZBERG, Maria ,  HUBNER, Bernd ,  ERDELJAN, Michael

IPC分类号： A61P1/18

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.

公开(公告)号：EP4285911A3

公开(公告)日：2024-04-10

申请号：EP23200924.1

申请日：2010-02-19

申请人： Astellas Pharma Inc. ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  KOSLOWSKI, Michael ,  HELFTENBEIN, Gerd ,  KORDEN, Walter ,  WÖLL, Stefan ,  OPREA, Gabriela-Elena

IPC分类号： C12N15/11 ,  A61K31/7088 ,  C07K14/47 ,  C07K16/18 ,  A61K39/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/04 ,  C12N15/113

摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.

公开(公告)号：EP3421499A1

公开(公告)日：2019-01-02

申请号：EP18188488.3

申请日：2011-03-10

申请人： Astellas Pharma Inc. ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  KOSLOWSKI, Michael ,  MITNACHT-KRAUS, Rita

IPC分类号： C07K16/30

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, hepatocellular cancer, colon cancer, pancreatic cancer, esophageal cancer, head & neck cancer, kidney cancer, in particular renal cell carcinoma, prostate cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid cancer, and the metastatic forms thereof. In one embodiment, the tumor disease is metastatic cancer in the lung.

公开(公告)号：EP3095791A1

公开(公告)日：2016-11-23

申请号：EP16176546.6

申请日：2004-09-10

申请人： BioNTech AG

发明人： TÜRECI, Özlem ,  SAHIN, Ugur ,  KOSLOWSKI, Michael

IPC分类号： C07K14/47 ,  C07K16/30 ,  C12Q1/68

CPC分类号： C07K14/4748 ,  C07K16/30 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/154

摘要： Erfindungsgemäß wurden Tumor-assoziiert exprimierte Genprodukte und die dafür kodierenden Nukleinsäuren identifiziert. Die vorliegende Erfindung betrifft die Therapie und Diagnose von Erkrankungen, bei denen diese Tumor-assoziiert exprimierten Genprodukte aberrant exprimiert werden. Des Weiteren betrifft die Erfindung Proteine, Polypeptide und Peptide, die Tumor-assoziiert exprimiert werden und die dafür kodierenden Nukleinsäuren.

摘要翻译： 药物组合物含有限制与肿瘤相关的抗原的表达或活性的药剂。 抗原具有由核酸编码的序列，其中核酸或序列来自SEQ ID NO：19-21,54-57,1-5,29,31-33,37,39,40 ，62,63,70,74,85-88作为部分或衍生物。 它还具有在严格条件下与核酸/序列组杂交的核酸，被退化的核酸和互补核酸。

公开(公告)号：EP2069538B1

公开(公告)日：2015-07-08

申请号：EP07818850.5

申请日：2007-10-09

申请人： BioNTech AG ,  Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  KOSLOWSKI, Michael

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  A61K31/7088 ,  A61K39/39558 ,  A61K47/6807 ,  C07K16/28 ,  C07K16/2866 ,  C07K16/40 ,  C07K2317/76 ,  C12N15/1138 ,  C12N15/8218 ,  C12N2310/11 ,  C12N2310/14 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2333/715 ,  G01N2333/7158 ,  G01N2333/916

公开(公告)号：EP1861118B1

公开(公告)日：2015-05-06

申请号：EP06723678.6

申请日：2006-03-23

申请人： BioNTech AG

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  KOSLOWSKI, Michael ,  HELFTENBEIN, Gerd ,  USENER, Dirk ,  SCHLÜTER, Volker

IPC分类号： A61K39/00 ,  A61K48/00 ,  C07K14/47

CPC分类号： G01N33/57492 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G06F19/22