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公开(公告)号：EP2069538B1
公开(公告)日：2015-07-08
申请号：EP07818850.5
申请日：2007-10-09
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , A61K31/7088 , A61K39/39558 , A61K47/6807 , C07K16/28 , C07K16/2866 , C07K16/40 , C07K2317/76 , C12N15/1138 , C12N15/8218 , C12N2310/11 , C12N2310/14 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , G01N33/57484 , G01N33/57492 , G01N2333/715 , G01N2333/7158 , G01N2333/916
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公开(公告)号：EP1924600B1
公开(公告)日：2013-08-28
申请号：EP06791878.9
申请日：2006-09-06
申请人： Ganymed Pharmaceuticals AG , Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , USENER, Dirk
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/5256 , A61K2039/54 , A61K2039/57 , A61K2039/572 , C07K14/4748 , C07K16/2803 , C07K16/30 , C07K2317/34 , C12Q1/6886 , C12Q2600/158 , G01N33/574
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3.发明公开
公开(公告)号：EP2069538A1
公开(公告)日：2009-06-17
申请号：EP07818850.5
申请日：2007-10-09
申请人： Ganymed Pharmaceuticals AG , Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , A61K31/7088 , A61K39/39558 , A61K47/6807 , C07K16/28 , C07K16/2866 , C07K16/40 , C07K2317/76 , C12N15/1138 , C12N15/8218 , C12N2310/11 , C12N2310/14 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , G01N33/57484 , G01N33/57492 , G01N2333/715 , G01N2333/7158 , G01N2333/916
摘要： The present invention relates to methods which make possible to assess and/or prognose a cancer disease, the metastatic behaviour of a cancer disease and/or the occurrence of a relapse of cancer according to the levels of expression of TPTE and CXCR4. In particular, the methods of the invention make possible to assess and/or prognose the occurrence of cancer metastasis, in particular distant metastasis. Preferably, the methods of the invention allow to discriminate malign from benign conditions.
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4.发明公开IDENTIFICATION OF TUMOR-ASSOCIATED ANTIGENS FOR DIAGNOSIS AND THERAPY 有权鉴定TUMORASSOZIIERTER抗原FÜRDIE DIAGNOSE UNDE THERAPIE
公开(公告)号：EP1924600A2
公开(公告)日：2008-05-28
申请号：EP06791878.9
申请日：2006-09-06
申请人： Ganymed Pharmaceuticals AG , Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , USENER, Dirk
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/5256 , A61K2039/54 , A61K2039/57 , A61K2039/572 , C07K14/4748 , C07K16/2803 , C07K16/30 , C07K2317/34 , C12Q1/6886 , C12Q2600/158 , G01N33/574
摘要： The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
摘要翻译： 本发明涉及其表达与癌症疾病相关的遗传产物。 本发明还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。
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公开(公告)号：EP3095791A1
公开(公告)日：2016-11-23
申请号：EP16176546.6
申请日：2004-09-10
申请人： BioNTech AG
发明人： TÜRECI, Özlem , SAHIN, Ugur , KOSLOWSKI, Michael
CPC分类号： C07K14/4748 , C07K16/30 , C07K2317/34 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154
摘要： Erfindungsgemäß wurden Tumor-assoziiert exprimierte Genprodukte und die dafür kodierenden Nukleinsäuren identifiziert. Die vorliegende Erfindung betrifft die Therapie und Diagnose von Erkrankungen, bei denen diese Tumor-assoziiert exprimierten Genprodukte aberrant exprimiert werden. Des Weiteren betrifft die Erfindung Proteine, Polypeptide und Peptide, die Tumor-assoziiert exprimiert werden und die dafür kodierenden Nukleinsäuren.
摘要翻译： 药物组合物含有限制与肿瘤相关的抗原的表达或活性的药剂。 抗原具有由核酸编码的序列，其中核酸或序列来自SEQ ID NO：19-21,54-57,1-5,29,31-33,37,39,40 ，62,63,70,74,85-88作为部分或衍生物。 它还具有在严格条件下与核酸/序列组杂交的核酸，被退化的核酸和互补核酸。
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6.发明公开TUMOR VACCINATION INVOLVING A HUMORAL IMMUNE RESPONSE AGAINST SELF-PROTEINS 有权TUMORIMFPUNG麻醉师EINER HUMORALEN免疫GEGEN SELBSTPROTEINE
公开(公告)号：EP2547695A1
公开(公告)日：2013-01-23
申请号：EP11707355.1
申请日：2011-03-09
发明人： KLAMP, Thorsten , SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , HILLER, Thomas , SCHUMACHER, Jens
CPC分类号： C07K14/4748 , A61K39/0011 , A61K2039/5156 , A61K2039/523 , A61K2039/5258 , A61K2039/53 , A61K2039/57 , A61K2039/575 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N2730/10123 , C12N2730/10134 , C12N2730/10143 , C12N2730/10171
摘要： The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.
摘要翻译： 本发明涉及使用包含全部或部分乙型肝炎病毒核心抗原蛋白的嵌合蛋白和包含衍生自肿瘤相关抗原的细胞外部分的表位的氨基酸序列的肿瘤免疫治疗，特别是肿瘤免疫治疗。 特别地，本发明提供了包含所述嵌合蛋白的病毒样颗粒，其可用于在受试者中针对肿瘤相关抗原，特别是针对在其表面上携带所述肿瘤相关抗原的细胞引起体液免疫应答，其中 肿瘤相关抗原是所述受试者的自身蛋白质。
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7.发明授权
公开(公告)号：EP1861118B1
公开(公告)日：2015-05-06
申请号：EP06723678.6
申请日：2006-03-23
申请人： BioNTech AG
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , HELFTENBEIN, Gerd , USENER, Dirk , SCHLÜTER, Volker
CPC分类号： G01N33/57492 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G06F19/22
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公开(公告)号：EP2714071A2
公开(公告)日：2014-04-09
申请号：EP12723117.3
申请日：2012-05-23
申请人： Biontech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , KREITER, Sebastian , DIKEN, Mustafa , DIEKMANN, Jan , KOSLOWSKI, Michael , BRITTEN, Cedrik , CASTLE, John , LÖWER, Martin , RENARD, Bernhard , OMOKOKO, Tana , DE GRAAF, Johannes Hendrikus
CPC分类号： A61K39/0011 , C12Q1/6886 , C12Q2600/156 , G16B20/00 , G16B40/00
摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.
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