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    SINGLE-CHAIN TNF LIGAND FAMILY MOLECULES AND FUSION PROTEINS AND DERIVATIVES THEREOF
    1.
    发明公开
    SINGLE-CHAIN TNF LIGAND FAMILY MOLECULES AND FUSION PROTEINS AND DERIVATIVES THEREOF 审中-公开
    单链TNF配体家族分子和融合蛋白及其衍生物

    公开(公告)号：EP3271395A1

    公开(公告)日：2018-01-24

    申请号：EP16714290.0

    申请日：2016-03-18

    申请人： Universität Stuttgart ,  Biontech AG

    发明人： SAHIN, Ugur ,  KONTERMANN, Roland ,  PFIZENMAIER, Klaus ,  SIEGEMUND, Martin ,  HUTT, Meike ,  SEIFERT, Oliver

    IPC分类号： C07K16/28 ,  C07K16/32 ,  C07K14/705

    CPC分类号： C07K16/2863 ,  C07K14/70575 ,  C07K16/32 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/91

    摘要： The present invention relates to a polypeptide comprising a component A with at least three tumor necrosis factor (TNF) homology domains of TNF-ligand family members (THD) in which C-terminal and N-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional C-terminal and/or N-terminal amino acids of the THD or variants thereof, and a component B comprising a dimerization domain. Further, the present invention relates to a polypeptide comprising at least three THDs in which C-terminal and N-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional C-terminal and/or N-terminal amino acids of the THD or variants thereof. Further, the invention relates to a nucleic acid comprising said polypeptides, a vector comprising said nucleic acid and a pharmaceutical composition comprising said polypeptides, or said nucleic acids or said vector. Further, the present invention relates to said polypeptides, said nucleic acid or said vector for the use as a medicament or for the use in the diagnosis, prophylaxis or treatment of hyperproliferative disorders and inflammatory disorders.

    DIFFERENTIELL IN TUMOREN EXPRIMIERTE GENPRODUKTE UND DEREN VERWENDUNG
    2.
    发明公开
    DIFFERENTIELL IN TUMOREN EXPRIMIERTE GENPRODUKTE UND DEREN VERWENDUNG 审中-公开

    公开(公告)号：EP3095791A1

    公开(公告)日：2016-11-23

    申请号：EP16176546.6

    申请日：2004-09-10

    申请人： BioNTech AG

    发明人： TÜRECI, Özlem ,  SAHIN, Ugur ,  KOSLOWSKI, Michael

    IPC分类号： C07K14/47 ,  C07K16/30 ,  C12Q1/68

    CPC分类号： C07K14/4748 ,  C07K16/30 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/154

    摘要： Erfindungsgemäß wurden Tumor-assoziiert exprimierte Genprodukte und die dafür kodierenden Nukleinsäuren identifiziert. Die vorliegende Erfindung betrifft die Therapie und Diagnose von Erkrankungen, bei denen diese Tumor-assoziiert exprimierten Genprodukte aberrant exprimiert werden. Des Weiteren betrifft die Erfindung Proteine, Polypeptide und Peptide, die Tumor-assoziiert exprimiert werden und die dafür kodierenden Nukleinsäuren.

    摘要翻译： 药物组合物含有限制与肿瘤相关的抗原的表达或活性的药剂。 抗原具有由核酸编码的序列，其中核酸或序列来自SEQ ID NO：19-21,54-57,1-5,29,31-33,37,39,40 ，62,63,70,74,85-88作为部分或衍生物。 它还具有在严格条件下与核酸/序列组杂交的核酸，被退化的核酸和互补核酸。