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20 条记录 (耗时 0.03 秒)

    NOVEL COMPOUNDS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS
    14.
    发明公开
    NOVEL COMPOUNDS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS 有权
    新化合物和组合物用于癌症干细胞从瞄准

    公开(公告)号：EP2547334A1

    公开(公告)日：2013-01-23

    申请号：EP11757134.9

    申请日：2011-03-21

    申请人： Boston Biomedical, Inc.

    发明人： LI, Chiang, Jia ,  LEGGETT, David ,  LI, Youzhi ,  LI, Wei

    IPC分类号： A61K31/27

    CPC分类号： A61K31/343 ,  A61K31/27 ,  C07D307/92 ,  Y10T428/2982

    摘要： The invention provides naphthofuran compounds, polymorphs of naphthofuran compounds, naphthofuran compounds in particle form, purified compositions that contain one or more naphthofuran compounds, purified compositions that contain one or more naphthofuran compounds in particle form, methods of producing these naphthofuran compounds, polymorphs, purified compositions and/or particle forms, and methods of using these naphthofuran compounds, polymorphs, purified compositions and/or particle forms to treat subjects in need thereof.

    A NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS
    17.
    发明公开
    A NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS 审中-公开
    一组新的STAT3途径抑制剂和癌症干细胞通路抑制剂

    公开(公告)号：EP3050566A2

    公开(公告)日：2016-08-03

    申请号：EP16156335.8

    申请日：2008-09-10

    申请人： Boston Biomedical, Inc.

    发明人： LI, Chiang, Jia ,  JIANG,, Zhiwei ,  ROGOFF, Harry ,  LI, Youzhi ,  LIU, Jifeng ,  LI, Wei

    IPC分类号： A61K31/505 ,  A61K31/55 ,  A61K38/17 ,  A61P35/00

    CPC分类号： C07D307/92 ,  A61K31/38 ,  C07D333/74 ,  Y02A50/465

    摘要： The present invention relates to the use of a novel class of cancer stem cell pathway (CSCP) inhibitors; to methods of using such compounds to treat refractory, recurrent, or metastatic cancers; to methods of selective killing cancer cells by using such compounds with specific administration regiment; to methods of targeting cancer stem cells by inhibiting Stat3 pathway; to methods of using novel compounds in the treatment of conditions or disorders in a mammal related to aberrant Stat3 pathway activity; and to processes for preparing such compounds and intermediates thereof, and to the pharmaceutical composition of relevant compounds, and to the specific methods of administration of these compounds.

    摘要翻译： 本发明涉及一类新型癌症干细胞通路（CSCP）抑制剂的用途; 涉及使用这些化合物来治疗难治性，复发性或转移性癌症的方法; 通过使用具有特定给药方案的这种化合物选择性杀死癌细胞的方法; 涉及通过抑制Stat3途径靶向癌症干细胞的方法; 涉及使用新化合物治疗哺乳动物与异常Stat3途径活性有关的病症或障碍的方法; 并涉及制备这些化合物及其中间体的方法，以及相关化合物的药物组合物，以及这些化合物的具体给药方法。