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11.发明授权
公开(公告)号：EP3154973B1
公开(公告)日：2018-03-21
申请号：EP15729057.8
申请日：2015-06-05
IPC分类号： C07D471/18 , A61K31/4748 , A61P25/00
CPC分类号： C07D471/18
摘要： The disclosure provides compounds of formula I including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders. [INSERT CHEMICAL STRUCTURE HERE] I
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12.发明公开BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING 审中-公开苯并二氮杂二聚物，其偶联物，以及制备和使用方法
公开(公告)号：EP3245213A1
公开(公告)日：2017-11-22
申请号：EP16703196.2
申请日：2016-01-13
发明人： ZHANG, Yong , MCDONALD, Ivar M. , CHOWDARI, Naidu S. , HUYNH, Tram N. , BORZILLERI, Robert M. , GANGWAR, Sanjeev
IPC分类号： C07D519/00 , C07D487/04 , A61K31/437 , A61P35/00
摘要： Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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13.发明公开TRICYCLIC COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 有权TRICYCLISCHE VERBINDUNGEN ALS NIKOTINISCHE ALPHA-7-ACETYLCHOLINREZEPTORLIGANDEN
公开(公告)号：EP3154973A1
公开(公告)日：2017-04-19
申请号：EP15729057.8
申请日：2015-06-05
IPC分类号： C07D471/18 , A61K31/4748 , A61P25/00
CPC分类号： C07D471/18
摘要： The disclosure provides compounds of formula I including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders. [INSERT CHEMICAL STRUCTURE HERE] I
摘要翻译： 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是烟碱7受体的配体，可用于治疗中枢神经系统的各种疾病，特别是情感和神经变性疾病。 [INSERT CHEMICAL STRUCTURE HERE] I
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14.发明授权AZA-BICYCLIC AMINE N-OXIDE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGAND PRO-DRUGS 有权AZA双环胺-N-氧化物化合物如α-7烟碱ACETYLCHOLINREZEPTORLIGAND前药
公开(公告)号：EP2563796B1
公开(公告)日：2015-03-18
申请号：EP11722648.0
申请日：2011-04-29
发明人： LENTZ, Kimberley A. , DENTON, Rex , COOK, James H., II , MCDONALD, Ivar M. , KING, Dalton , OLSON, Richard E. , WANG, Nenghui , MATE, Robert A. , IWUAGWU, Christiana I. , ZUSI, F. Christopher , MACOR, John E. , HILL, Matthew D. , FANG, Haiquan
IPC分类号： C07D498/10 , A61K31/435 , A61K31/47 , A61K31/497 , A61K31/506 , A61P25/00
CPC分类号： C07D498/10
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