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1.发明公开AZA-BICYCLIC AMINE N-OXIDE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGAND PRO-DRUGS 有权AZA-BICYCLISCHE AMIN-N-OXIDVERBINDUNGEN ALS ALPHA-7-NIKOTINISCHE ACETYLCHOLINREZEPTORLIGAND-PRODRUGS
公开(公告)号：EP2563796A1
公开(公告)日：2013-03-06
申请号：EP11722648.0
申请日：2011-04-29
发明人： LENTZ, Kimberley A. , DENTON, Rex , COOK, James H., II , MCDONALD, Ivar M. , KING, Dalton , OLSON, Richard E. , WANG, Nenghui , MATE, Robert A. , IWUAGWU, Christiana I. , ZUSI, F. Christopher , MACOR, John E. , HILL, Matthew D. , FANG, Haiquan
IPC分类号： C07D498/10 , A61K31/435 , A61K31/47 , A61K31/497 , A61K31/506 , A61P25/00
CPC分类号： C07D498/10
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are prodrugs for ligands, agonists, and partial agonists for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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公开(公告)号：EP3774824A1
公开(公告)日：2021-02-17
申请号：EP19720286.4
申请日：2019-04-12
发明人： SCHMIDT, Michael Anthony , ZHENG, Bin , KNOUSE, Kyle , DEGRUYTER, Justine , EASTGATE, Martin D. , BARAN, Phil , EWING, William R. , OLSON, Richard E. , MCDONALD, Ivar M.
IPC分类号： C07F9/6574 , C07H19/00 , C07H19/11 , C07H21/04
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3.发明授权AZABICYCLIC COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 有权AYABICYCLISCHE化合物如α-7烟碱乙酰胆碱REZPETORLIGANDEN
公开(公告)号：EP2493894B1
公开(公告)日：2014-01-29
申请号：EP10776869.9
申请日：2010-10-26
发明人： MCDONALD, Ivar M. , MATE, Robert A. , COOK II, James H. , KING, Dalton , OLSON, Richard E. , WANG, Nenghui , IWUAGWU, Christiana I. , ZUSI, Christopher, F. , MACOR, John E.
IPC分类号： C07D498/20 , C07D519/00 , A61K31/55 , A61P25/18 , A61P25/28
CPC分类号： C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic alpha7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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公开(公告)号：EP3245213B1
公开(公告)日：2020-03-04
申请号：EP16703196.2
申请日：2016-01-13
发明人： ZHANG, Yong , MCDONALD, Ivar M. , CHOWDARI, Naidu S. , HUYNH, Tram N. , BORZILLERI, Robert M. , GANGWAR, Sanjeev
IPC分类号： C07D519/00 , C07D487/04 , A61K31/437 , A61P35/00
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5.发明公开AZABICYCLIC COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 有权AYABICYCLISCHE化合物如α-7烟碱乙酰胆碱REZPETORLIGANDEN
公开(公告)号：EP2493894A1
公开(公告)日：2012-09-05
申请号：EP10776869.9
申请日：2010-10-26
发明人： MCDONALD, Ivar M. , MATE, Robert A. , COOK II, James H. , KING, Dalton , OLSON, Richard E. , WANG, Nenghui , IWUAGWU, Christiana I. , ZUSI, Christopher, F. , MACOR, John E.
IPC分类号： C07D498/20 , C07D519/00 , A61K31/55 , A61P25/18 , A61P25/28
CPC分类号： C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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6.发明公开AZABICYCLO[2.2.1]HEPTANE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 有权亚氨基胆碱[2.2.1] HEPTANVERBINDUNGEN ALS ALPHA-7-非诺贝特 - 乙酰胆碱酯酶REZPETORLIGANDEN
公开(公告)号：EP2493893A1
公开(公告)日：2012-09-05
申请号：EP10774092.0
申请日：2010-10-25
发明人： MCDONALD, Ivar M. , MATE, Robert A. , COOK II, James H. , KING, Dalton , OLSON, Richard E. , WANG, Nenghui , IWUAGWU, Christiana I. , ZUSI, F. Christopher , HILL, Matthew D. , FANG, Haiquan , MACOR, John E.
IPC分类号： C07D498/20 , C07D519/00 , A61K31/439 , A61P25/18 , A61P25/28
CPC分类号： C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including Ia, Ib, Ic, or Id, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders (Formula I).
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公开(公告)号：EP3947680A2
公开(公告)日：2022-02-09
申请号：EP20722089.8
申请日：2020-04-02
发明人： ANDERSON, Brian R. , OLSON, Richard E. , MCDONALD, Ivar M. , MERCER, Stephen E. , HAGEDORN, Peter , JENSEN, Marianne Lerbech
IPC分类号： C12N15/113 , C07K14/515
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8.发明授权AZABICYCLO[2.2.1]HEPTANE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 有权氮杂双环[2.2.1]庚烷化合物AS ALPHA-7烟碱乙酰胆碱REZPETORLIGANDEN
公开(公告)号：EP2493893B1
公开(公告)日：2014-01-15
申请号：EP10774092.0
申请日：2010-10-25
发明人： MCDONALD, Ivar M. , MATE, Robert A. , COOK II, James H. , KING, Dalton , OLSON, Richard E. , WANG, Nenghui , IWUAGWU, Christiana I. , ZUSI, F. Christopher , HILL, Matthew D. , FANG, Haiquan , MACOR, John E.
IPC分类号： C07D498/20 , C07D519/00 , A61K31/439 , A61P25/18 , A61P25/28
CPC分类号： C07D498/20 , C07D519/00
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公开(公告)号：EP3814348A1
公开(公告)日：2021-05-05
申请号：EP19744923.4
申请日：2019-06-26
发明人： VELAPARTHI, Upender , CHUPAK, Louis S. , DARNE, Chetan Padmakar , DING, Min , GENTLES, Robert G. , HUANG, Yazhong , KAMBLE, Manjunatha Narayana Rao , MARTIN, Scott W. , MANNOORI, Raju , MCDONALD, Ivar M. , OLSON, Richard E. , RAHAMAN, Hasibur , JALAGAM, Prasada Rao , ROY, Saumya , TONUKUNURU, Gopikishan , VELAIAH, Sivasudar , WARRIER, Jayakumar Sankara , ZHENG, Xiaofan , TOKARSKI, John S. , DASGUPTA, Bireshwar , REDDY, Kotha Rathnakar , RAJA, Thiruvenkadam
IPC分类号： C07D471/04 , A61P35/00 , A61K31/496
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公开(公告)号：EP3814347A1
公开(公告)日：2021-05-05
申请号：EP19740166.4
申请日：2019-06-26
发明人： CHUPAK, Louis S. , DING, Min , GENTLES, Robert G. , HUANG, Yazhong , MARTIN, Scott W. , MCDONALD, Ivar M. , MERCER, Stephen E. , OLSON, Richard E. , VELAPARTHI, Upender , WICHROSKI, Michael , ZHENG, Xiaofan
IPC分类号： C07D471/04 , A61P35/00 , A61K31/496
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