公开(公告)号：EP2268298A1

公开(公告)日：2011-01-05

申请号：EP09719379.1

申请日：2009-03-12

申请人： Compugen Ltd.

发明人： KLIGER, Yossef ,  LEVY, Ofer ,  BORUKHOV, Itamar ,  AMIR, Anat ,  OREN, Anat

IPC分类号： A61K38/17 ,  C07K14/47

CPC分类号： C07K14/4703 ,  A61K38/00

摘要： The subject invention provides gp96-derived peptides or homologs or derivatives thereof, pharmaceutical composition comprising them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins comprising them.

公开(公告)号：EP2190469B1

公开(公告)日：2015-02-25

申请号：EP08829443.4

申请日：2008-09-03

申请人： Compugen Ltd.

发明人： LEVINE, Zurit ,  ROSENBERG, Avi ,  ROTMAN, Galit ,  NOVIK, Amit ,  TOPORIK, Amir ,  KINAR, Yaron ,  NEMZER, Sergey ,  KOIFMAN, Cynthia ,  BEIMAN, Merav ,  DASSA, Liat ,  WALACH, Shira ,  MONTIA, Eve ,  SAMEACH-GREENWALD, Shirley ,  PERGAM, Tania ,  MILO, Dalit ,  COHEN-DAYAG, Anat ,  LEVY, Ofer ,  BUBIS, Marina

IPC分类号： A61K39/00

CPC分类号： C07K16/30 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0005 ,  A61K39/0008 ,  A61K39/39 ,  A61K39/395 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/545 ,  A61N5/10 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/82 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/60 ,  C07K2319/70 ,  G01N33/564 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2500/04

摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against C1ORF32 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation is also provided. This invention further relates to the discovery of extracellular domains of C1ORF32 and its variants awhich are suitable targets for cancer therapy, and drug development.

公开(公告)号：EP2373690A2

公开(公告)日：2011-10-12

申请号：EP09799402.4

申请日：2009-12-08

申请人： Compugen Ltd.

发明人： LEVINE, Zurit ,  ROSENBERG, Avi Yeshah ,  ROTMAN, Galit ,  TOPORIK, Amir ,  KINAR, Yaron ,  NEMZAR, Sergey ,  COHEN-DAYAG, Anat ,  WALACH, Shira ,  SAMEACH-GREENWALD, Shirley ,  DASSA, Liat ,  BEIMAN, Merav ,  MONTIA, Eve ,  LEVY, Ofer ,  NOVIK, Amit

IPC分类号： C07K16/28 ,  C07K14/705

CPC分类号： C07K16/28 ,  A61K38/00 ,  A61K39/39558 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3038 ,  C07K16/3053 ,  C07K16/3061 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57484 ,  G01N33/577 ,  G01N2333/47

摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against FAM26F antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of FAM26F, proteins and variants, and therapeutic usages thereof.

摘要翻译： 本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供了针对FAM26F抗原的治疗性抗体，其在癌症中差异表达，以及诊断和治疗用途。 本发明还涉及FAM26F的细胞外结构域，蛋白质和变体及其治疗用途。

公开(公告)号：EP2373690B1

公开(公告)日：2015-02-11

申请号：EP09799402.4

申请日：2009-12-08

申请人： Compugen Ltd.

发明人： LEVINE, Zurit ,  ROSENBERG, Avi Yeshah ,  ROTMAN, Galit ,  TOPORIK, Amir ,  KINAR, Yaron ,  NEMZAR, Sergey ,  COHEN-DAYAG, Anat ,  WALACH, Shira ,  SAMEACH-GREENWALD, Shirley ,  DASSA, Liat ,  BEIMAN, Merav ,  MONTIA, Eve ,  LEVY, Ofer ,  NOVIK, Amit

IPC分类号： C07K16/28 ,  C07K14/705

CPC分类号： C07K16/28 ,  A61K38/00 ,  A61K39/39558 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3038 ,  C07K16/3053 ,  C07K16/3061 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57484 ,  G01N33/577 ,  G01N2333/47

摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against FAM26F antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of FAM26F, proteins and variants, and therapeutic usages thereof.

公开(公告)号：EP2756093A2

公开(公告)日：2014-07-23

申请号：EP13744328.9

申请日：2013-01-31

申请人： Compugen Ltd.

发明人： COJOCARU, Gad S. ,  DASSA, Liat ,  PERGAM, Tania ,  LEVINE, Zurit ,  LEVY, Ofer ,  BRIANTE, Raffaella ,  SINGH, Shweta ,  WATSON, Susan R. ,  ROTMAN, Galit

IPC分类号： C12P21/06

CPC分类号： C07K16/2803 ,  A61K31/675 ,  A61K39/0011 ,  A61K39/3955 ,  A61K45/06 ,  A61K49/0004 ,  A61K2039/505 ,  A61N5/062 ,  A61N5/10 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2319/00 ,  G01N33/57407 ,  G01N2333/70503

摘要： This invention relates to C1ORF32-specific antibodies, antibody fragments, alternative scaffolds, conjugates and compositions comprising same, for treatment of cancer.

摘要翻译： 本发明涉及特定C1ORF32抗体，抗体片段，替代支架，缀合物和组合物，其包括相同的，用于治疗癌症。

公开(公告)号：EP2315775A2

公开(公告)日：2011-05-04

申请号：EP09787476.2

申请日：2009-07-20

申请人： Compugen Ltd.

发明人： KLIGER, Yossef ,  BORUKHOV, Itamar ,  LEVY, Ofer ,  TIRAN, Zohar ,  WOOL, Assaf ,  SCHREIBER, Ehud ,  AMIR, Anat ,  LEVINE, Zurit ,  TOPORIK, Amir

IPC分类号： C07K14/515

CPC分类号： C07K14/515 ,  A61K38/14 ,  A61K38/1891 ,  A61K45/06 ,  C07K9/00 ,  C07K9/001

摘要： In at least some embodiments, the subject invention provides angiopoietin-derived peptides or homologs or derivatives thereof, pharmaceutical composition comprising them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins comprising them.

公开(公告)号：EP2245055A2

公开(公告)日：2010-11-03

申请号：EP09706816.7

申请日：2009-02-01

申请人： Compugen Ltd.

发明人： LEVIN, Zurit ,  ROSENBERG, Avi Yeshah ,  ROTMAN, Galit ,  TOPORIK, Amir ,  DASSA, Liat ,  BEIMAN, Merav ,  LEVY, Ofer ,  NEMZAR, Sergey ,  WALACH, Shira ,  SAMEACH-GREENWALD, Shirley ,  MONTIA, Eve ,  KINAR, Yaron ,  COHEN-DAYAG, Anat

IPC分类号： C07K14/47

CPC分类号： A61K39/3955 ,  C07K14/47 ,  C07K16/28 ,  C07K16/2887 ,  C07K16/2896 ,  C07K2317/21 ,  C07K2317/34

摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KIAA0746, CD20 or CD55 antigens, which are differentially expressed in cancer and in specific blood cells, and diagnostic and therapeutic usages. This invention further relates to the discovery of extracellular domains of KIAA0746 and its variants, CD20 and its variants, CD55 and its variants, which are suitable targets for immunotherapy, cancer therapy, treatment of inflammatory, allergic and autoimmune disorders, and drug development.

公开(公告)号：EP2190469A2

公开(公告)日：2010-06-02

申请号：EP08829443.4

申请日：2008-09-03

申请人： Compugen Ltd.

发明人： LEVINE, Zurit ,  ROSENBERG, Avi ,  ROTMAN, Galit ,  NOVIK, Amit ,  TOPORIK, Amir ,  KINAR, Yaron ,  NEMZER, Sergey ,  KOIFMAN, Cynthia ,  BEIMAN, Merav ,  DASSA, Liat ,  WALACH, Shira ,  MONTIA, Eve ,  SAMEACH-GREENWALD, Shirley ,  PERGAM, Tania ,  MILO, Dalit ,  COHEN-DAYAG, Anat ,  LEVY, Ofer ,  BUBIS, Marina

IPC分类号： A61K39/00

CPC分类号： C07K16/30 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0005 ,  A61K39/0008 ,  A61K39/39 ,  A61K39/395 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/545 ,  A61N5/10 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/82 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/60 ,  C07K2319/70 ,  G01N33/564 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2500/04

摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against C1ORF32 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation is also provided. This invention further relates to the discovery of extracellular domains of C1ORF32 and its variants awhich are suitable targets for cancer therapy, and drug development.

摘要翻译： 本发明涉及一个新的目标生产免疫和非免疫的疗法和用于疾病的诊断。 更具体地，本发明提供针对抗原C1ORF32，被预测的共刺激家庭成员和其中在癌症，包括肺癌，卵巢癌和结肠癌，以及诊断和治疗用途被差分过表达的治疗性抗体。 因此提供了一种用于合成调制B7共刺激抗体的使用。 本发明进一步涉及药物开发C1ORF32的胞外结构域及其变种awhich是用于癌症治疗的合适的目标，和的发现。