公开(公告)号：EP1572091A3

公开(公告)日：2005-09-28

申请号：EP03763455.7

申请日：2003-07-08

申请人： GENENTECH, INC.

发明人： PHILLIPS, Heidi, S. ,  MENG, Yu-Ju, G. ,  VANDLEN, Richard, L.

IPC分类号： A61K6/00

公开(公告)号：EP0870026B1

公开(公告)日：2004-05-19

申请号：EP96945295.2

申请日：1996-12-19

申请人： Genentech, Inc.

发明人： DE SAUVAGE, Frederic, J. ,  LEVIN, Nancy ,  VANDLEN, Richard, L.

IPC分类号： C12N15/16 ,  C07K14/575 ,  A61K38/22 ,  C12N15/70 ,  C12N1/21

CPC分类号： C07K14/5759 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention concerns long half-life derivative of the obesity protein OB. The invention specifically concerns OB protein-immunoglobulin chimeras and polyethylene glycol (PEG)-OB derivatives, which have extended half-life as compared to the corresponding native OB proteins. The invention further relates to methods for appetite and/or weight reduction and for treating other physiological conditions by using the long half-life derivatives of OB.

公开(公告)号：EP0586607B1

公开(公告)日：2003-07-23

申请号：EP92915976.2

申请日：1992-05-21

申请人： GENENTECH, INC.

发明人： VANDLEN, Richard, L. ,  HOLMES, William, E.

IPC分类号： C07K14/475 ,  C12P21/02 ,  C12N5/10

CPC分类号： C07K14/4756 ,  A61K38/00

摘要： A novel polypeptide with binding affinity for the p185 receptor, designated heregulin- alpha , has been identified and purified from cultured human cells. DNA sequences encoding additional heregulin polypeptides, designated heregulin- alpha , heregulin- beta 1, heregulin- beta 2, heregulin- beta 2-like, and heregulin- beta 3, have been isolated, sequenced and expressed. Provided herein are nucleic acid sequences encoding the amino acid sequences of heregulins useful in the production of heregulins by recombinant means. Further provided are the amino acid sequences of heregulins and purification methods therefor. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.