公开(公告)号：EP2514436B1

公开(公告)日：2017-12-20

申请号：EP12169572.0

申请日：2008-11-07

申请人： Genentech, Inc.

发明人： ABBAS, Alexander, R. ,  DANILENKO, Dimitry, M. ,  DE SAUVAGE, Frederic, J. ,  GHILARDI, Nico, P. ,  MODRUSAN, Zora ,  OUYANG, Wenjun ,  VALDEZ, Patricia, A. ,  ZHENG, Yan

IPC分类号： A61K38/20 ,  A61K38/17 ,  A61K38/16 ,  A61P31/00

CPC分类号： A61K38/191 ,  A61K38/1709 ,  A61K38/20 ,  A61K38/204 ,  Y02A50/473

摘要： The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.

公开(公告)号：EP3253784A1

公开(公告)日：2017-12-13

申请号：EP16732795.6

申请日：2016-02-04

申请人： Genentech, Inc. ,  Curis, Inc. ,  Assistance Publique-Hôpitaux de Paris ,  Université Paris Diderot - Paris 7

发明人： DE SAUVAGE, Frederic, J. ,  YAUCH, Robert, L. ,  DIJKGRAAF, Gerrit, J.P. ,  SHARPE, Hayley ,  BASSET-SEGUIN, Nicole

IPC分类号： C07K14/705 ,  C12Q1/68

摘要： The emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy represents a major mechanism of acquired drug resistance. Here, mutations in the serpentine receptor, Smoothened (SMO) are described, which result in resistance to a Hedgehog (Hh) pathway inhibitor, such as in medulloblastoma. Amino acid substitutions in conserved residues of SMO maintain Hh signaling, but result in the inability of the Hh pathway inhibitor, GDC-0449, to bind SMO and suppress the pathway. In some embodiments, the disclosure provides for novel mutant SMO proteins and nucleic acids and for screening methods to detect SMO mutations and methods to screen for drugs that specifically modulate mutant SMO exhibiting drug resistance.

公开(公告)号：EP2514436A3

公开(公告)日：2013-01-16

申请号：EP12169572.0

申请日：2008-11-07

申请人： Genentech, Inc.

发明人： ABBAS, Alexander, R. ,  DANILENKO, Dimitry, M. ,  DE SAUVAGE, Frederic, J. ,  GHILARDI, Nico, P. ,  MODRUSAN, Zora ,  OUYANG, Wenjun ,  VALDEZ, Patricia, A. ,  ZHENG, Yan

IPC分类号： A61K38/20 ,  A61K38/17 ,  A61K38/16 ,  A61P31/00

CPC分类号： A61K38/191 ,  A61K38/1709 ,  A61K38/20 ,  A61K38/204 ,  Y02A50/473

摘要： The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.

摘要翻译： 本发明涉及通过调节宿主免疫应答来治疗微生物病症的组合物和方法。 更具体地，本发明涉及介导抗微生物免疫应答的组合物，以及使用这些组合物治疗微生物感染的方法。

公开(公告)号：EP1056868B1

公开(公告)日：2011-08-24

申请号：EP99909610.0

申请日：1999-02-25

申请人： Genentech, Inc.

发明人： DE SAUVAGE, Frederic, J. ,  ROSENTHAL, Arnon

IPC分类号： C12N15/54 ,  C12N9/12 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10

CPC分类号： C12N9/1205 ,  C07K2319/00

摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, immunoadhesins, agonists and antagonists to human and vertebrate fused.

公开(公告)号：EP1978973B1

公开(公告)日：2011-11-16

申请号：EP06850419.0

申请日：2006-12-13

申请人： Genentech, Inc. ,  Curis, Inc.

发明人： DE SAUVAGE, Frederic, J. ,  EVANGELISTA, Marie

IPC分类号： A61K31/7088 ,  A61K47/48 ,  G01N33/50 ,  C12N5/00 ,  A61P35/00

CPC分类号： C12Q1/485 ,  A61K31/7088 ,  A61K38/45 ,  A61K47/54 ,  A61K47/56 ,  A61K47/62 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6811 ,  A61K47/6843 ,  A61K48/00 ,  C07K16/40 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/351 ,  C12Y207/11 ,  C12Y207/12001 ,  G01N33/5011 ,  G01N33/5058 ,  G01N33/574 ,  G01N33/6893 ,  G01N2800/10 ,  G01N2800/12 ,  G01N2800/20 ,  G01N2800/28 ,  A61K2300/00

摘要： The present invention provides for a method of using CDC2L1, CSNK1A1, GYK, NEK1, PLK1, PRKAR1A, PRKRA, TTBK2 or TTK hedgehog kinase antagonists to inhibit hedgehog signaling, as well as treating and diagnosing disorders relating to hedgehog signaling or overexpression of hedgehog, including cancer, cell proliferative disorders, and angiogenesis, neurological disorders, as well as other conditions affected by hedgehog signaling such as hair growth, neural stem cell differentiation, chondrogenesis and osteogenesis, lung surfactant production, formation of lamellated bodies in lung cells.

公开(公告)号：EP1978973A2

公开(公告)日：2008-10-15

申请号：EP06850419.0

申请日：2006-12-13

申请人： Genentech, Inc. ,  Curis, Inc.

发明人： DE SAUVAGE, Frederic, J. ,  EVANGELISTA, Marie

IPC分类号： A61K31/7088

CPC分类号： C12Q1/485 ,  A61K31/7088 ,  A61K38/45 ,  A61K47/54 ,  A61K47/56 ,  A61K47/62 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6811 ,  A61K47/6843 ,  A61K48/00 ,  C07K16/40 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/351 ,  C12Y207/11 ,  C12Y207/12001 ,  G01N33/5011 ,  G01N33/5058 ,  G01N33/574 ,  G01N33/6893 ,  G01N2800/10 ,  G01N2800/12 ,  G01N2800/20 ,  G01N2800/28 ,  A61K2300/00

摘要： The present invention provides for a method of using CDC2L1, CSNK1A1, GYK, NEK1, PLK1, PRKAR1A, PRKRA, TTBK2 or TTK hedgehog kinase antagonists to inhibit hedgehog signaling, as well as treating and diagnosing disorders relating to hedgehog signaling or overexpression of hedgehog, including cancer, cell proliferative disorders, and angiogenesis, neurological disorders, as well as other conditions affected by hedgehog signaling such as hair growth, neural stem cell differentiation, chondrogenesis and osteogenesis, lung surfactant production, formation of lamellated bodies in lung cells.

公开(公告)号：EP1064376B1

公开(公告)日：2006-03-15

申请号：EP99913993.4

申请日：1999-03-19

申请人： GENENTECH, INC.

发明人： DE SAUVAGE, Frederic, J. ,  KLEIN, Robert, D. ,  PHILLIPS, Heidi, S. ,  ROSENTHAL, Arnon

IPC分类号： C12N15/12 ,  C07K14/71 ,  C12N15/85 ,  C12N15/70 ,  C12N15/81 ,  C12N1/19 ,  C12N5/10 ,  C12N1/21 ,  C07K19/00 ,  C07K16/28 ,  G01N33/68 ,  C12Q1/42 ,  A61K39/395

CPC分类号： C07K16/2863 ,  C07K14/71 ,  C07K2317/75 ,  C07K2319/00 ,  C12Q1/485 ,  G01N33/573 ,  G01N33/74 ,  G01N2500/04 ,  G01N2500/10

公开(公告)号：EP1071779A1

公开(公告)日：2001-01-31

申请号：EP99945688.2

申请日：1999-04-02

申请人： Genentech, Inc.

发明人： DE SAUVAGE, Frederic, J. ,  CARPENTER, David, A.

IPC分类号： C12N15/12 ,  C07K14/705 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/62 ,  C07K19/00 ,  C12N15/11 ,  G01N33/68

CPC分类号： C07K14/705 ,  C07K2319/00

摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, antibodies, vectors and host cells expressing, immunoadhesins, agonists and antagonists to patched-2.

公开(公告)号：EP3360567A1

公开(公告)日：2018-08-15

申请号：EP17208162.2

申请日：2008-11-07

申请人： Genentech, Inc.

发明人： ABBAS, Alexander, R. ,  DANILENKO, Dimitry, M. ,  DE SAUVAGE, Frederic, J. ,  GHILARDI, Nico, P. ,  MODRUSAN, Zora ,  OUYANG, Wenjun ,  VALDEZ, Patricia, A. ,  ZHENG, Yan

IPC分类号： A61K38/20 ,  A61K38/17 ,  A61K38/16 ,  A61P31/00

CPC分类号： A61K38/191 ,  A61K38/1709 ,  A61K38/20 ,  A61K38/204 ,  Y02A50/473

摘要： The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.

公开(公告)号：EP2217263A2

公开(公告)日：2010-08-18

申请号：EP08848478.7

申请日：2008-11-07

申请人： Genentech, Inc.

发明人： ABBAS, Alexander, R. ,  DANILENKO, Dimitry, M. ,  DE SAUVAGE, Frederic, J. ,  GHILARDI, Nico, P. ,  MODRUSAN, Zora ,  OUYANG, Wenjun ,  VALDEZ, Patricia, A. ,  ZHENG, Yan

IPC分类号： A61K38/20 ,  A61K38/16 ,  A61P31/00

CPC分类号： A61K38/191 ,  A61K38/1709 ,  A61K38/20 ,  A61K38/204 ,  Y02A50/473

摘要： The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.