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公开(公告)号：EP3297679A1
公开(公告)日：2018-03-28
申请号：EP16725810.2
申请日：2016-05-19
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Paris Descartes , Université Pierre et Marie Curie (Paris 6) , Université Paris Diderot - Paris 7 , Assistance Publique-Hôpitaux de Paris (APHP)
摘要： The present invention relates to the Transferrin (Tf) or an active fragment thereof for use in the treatment of retinal detachment and/or for use in the treatment of retinal detachment related to other diseases.
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12.发明授权METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF AN OCULAR DISEASE IN A SUBJECT 有权方法和药物组合物，眼睛疾病的患者中治疗
公开(公告)号：EP2603238B1
公开(公告)日：2014-07-30
申请号：EP11740931.8
申请日：2011-08-08
CPC分类号： A61K41/0047 , A61K9/0009 , A61K9/0048 , A61K41/0028 , A61K41/0033 , A61K47/6925 , A61K48/0083 , A61K49/223 , A61M37/0092
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13.发明公开METHODS AND COMPOSITIONS FOR STIMULATING REEPITHELIALISATION DURING WOUND HEALING 审中-公开方法和组合物刺激在伤口愈合的REEPITHELIALISATION
公开(公告)号：EP2582365A1
公开(公告)日：2013-04-24
申请号：EP11725465.6
申请日：2011-06-16
IPC分类号： A61K31/00 , A61K31/585 , A61P17/02 , A61P27/02 , A61K9/70
CPC分类号： A61K31/585 , A61K9/0014 , A61K9/0048 , A61K9/7023 , A61K31/00 , A61K31/575 , C12N15/1138 , C12N2310/11 , C12N2310/12 , C12N2310/14
摘要： The present invention relates to methods and compositions for stimulating reepithelialization during wound healing. More particularly, the present invention relates to a mmeralocorticoid receptor antagonist or an inhibitor of mineralocorticoid receptor gene expression for use in a method for stimulating reepithelialization of the skin or of the cornea during wound healing.
摘要翻译： 本发明涉及一种用于伤口愈合期间刺激表皮细胞再生的方法和组合物。 更具体地，本发明涉及一种mmeralocorticoid受体拮抗剂或在盐皮质激素受体基因表达的方法中使用的抑制剂，其用于刺激皮肤的或伤口愈合过程中的角膜表皮细胞再生。
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公开(公告)号：EP2582365B1
公开(公告)日：2019-03-20
申请号：EP11725465.6
申请日：2011-06-16
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15.发明公开METHODS AND COMPOSITIONS FOR THE TREATMENT OF FLUID ACCUMULATION IN AND/ OR UNDER THE RETINA 有权方法和组合物中和/或在视网膜下处理流体积累
公开(公告)号：EP2568986A1
公开(公告)日：2013-03-20
申请号：EP11718122.2
申请日：2011-05-10
IPC分类号： A61K31/585
CPC分类号： A61K31/573 , A61K9/0048 , A61K9/0051
摘要： The present invention provides methods and compositions for the treatment of fluid accumulation in and/or under the retina.
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16.发明公开
公开(公告)号：EP1871890A2
公开(公告)日：2008-01-02
申请号：EP06779741.5
申请日：2006-04-18
CPC分类号： C12N15/87 , A61K9/0048 , A61K38/00 , A61K48/00 , A61N1/0543 , A61N1/306 , A61N1/327 , A61N1/36046
摘要： The present invention relates, generally, to improved methods of delivering a biologically active agent, in particular a therapeutic or prophylactic nucleic acid, to the ocular sphere of a subject comprising administering said agent to the ciliary body tissue(s) or cells and/or to the extra-ocular muscle tissue or cells. More particularly, the invention relates to devices, their uses, notably in gene therapy, and to methods for treating pathologies of the ocular sphere by specific ciliary body tissue(s) or cells and/or extra-ocular muscle or cells administration of a therapeutic product and transfer thereof into the ocular tissue to be treated. This invention also relates to pharmaceutical compositions comprising the product in a form suitable for ciliary body tissue(s) or cells and/or extra-ocular muscle or cells administration, their preparation and uses.
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公开(公告)号：EP2590669B1
公开(公告)日：2016-08-31
申请号：EP11734062.0
申请日：2011-07-11
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Paris Descartes , Assistance Publique - Hôpitaux de Paris
CPC分类号： A61K38/40
摘要： Treatment of a disease associated with retinal degenerative disorder. The present invention relates to human Transferrin or an active fragment thereof for use in the treatment of a disease associated with retinal degenerative disorder.
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18.发明公开PHARMACEUTICAL COMPOSITIONS FOR PREVENTING GLUCOCORTICOID-INDUCED CORNEAL OR SKIN THINNING 审中-公开药物组合物预防糖皮质激素引起的皮肤角膜或更薄
公开(公告)号：EP3010588A1
公开(公告)日：2016-04-27
申请号：EP14731639.2
申请日：2014-06-20
申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , Université Paris Descartes , Université Pierre et Marie Curie (Paris 6) , Assistance Publique-Hôpitaux de Paris (APHP)
发明人： FARMAN, Nicolette , JAISSER, Frédéric , BEHAR-COHEN, Francine , ARACTINGI, Selin , NGUYEN, Van Tuan
IPC分类号： A61P27/02 , A61P17/00 , A61P29/00 , A61K31/585 , A61K9/06 , A61K9/08 , A61K31/573 , A61K9/00
CPC分类号： A61K31/585 , A61K9/0014 , A61K9/0048 , A61K31/573 , A61K45/06 , A61K2300/00
摘要： The present invention relates to method and pharmaceutical compositions for preventing glucocorticoid-induced corneal or skin thinning. In particular, the present invention relates to a mineralocorticoid receptor antagonist for topical use in a method for preventing or reducing glucocorticoid-induced corneal or skin thinning in a subject in need thereof. The invention also relates to a topical pharmaceutical composition comprising an amount of at least one glucocorticoid and an amount of at least one mineralocorticoid receptor antagonist or inhibitor of MR expression for use in a method for treating an inflammatory skin disease or an inflammatory disease of the cornea or of the anterior segment of the eye in a subject in need thereof.
摘要翻译： 本发明涉及的方法和用于预防糖皮质激素诱导的角膜或皮肤变薄的药物组合物。 特别地，本发明涉及一种盐皮质激素受体拮抗剂，其用于预防或降低需要其的受试者的糖皮质激素诱导的角膜变薄或皮肤的方法局部使用。 因此，本发明涉及局部药物组合物包含至少一种糖皮质激素的量的和中的至少一种盐皮质激素受体拮抗剂的量或抑制剂MR表达用于在方法中使用的用于治疗炎性皮肤疾病或角膜的炎症性疾病的治疗 或眼睛在需要其的受试者中的前段的。
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19.发明公开METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF AN OCULAR DISEASE IN A SUBJECT 有权方法和药物组合物，眼睛疾病的患者中治疗
公开(公告)号：EP2603238A1
公开(公告)日：2013-06-19
申请号：EP11740931.8
申请日：2011-08-08
CPC分类号： A61K41/0047 , A61K9/0009 , A61K9/0048 , A61K41/0028 , A61K41/0033 , A61K47/6925 , A61K48/0083 , A61K49/223 , A61M37/0092
摘要： A method of treating an ocular disease in a subject includes delivering a pharmaceutical composition into a ciliary muscle of the subject and inducing transfection of the therapeutic nucleic acid into the ciliary muscle by exposing the pharmaceutical composition to ultrasound. The pharmaceutical composition comprises echo-contrast agent microbubbles and a therapeutic nucleic acid.
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公开(公告)号：EP2590669A2
公开(公告)日：2013-05-15
申请号：EP11734062.0
申请日：2011-07-11
CPC分类号： A61K38/40
摘要： Treatment of a disease associated with retinal degenerative disorder. The present invention relates to human Transferrin or an active fragment thereof for use in the treatment of a disease associated with retinal degenerative disorder.
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