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    COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
    15.
    发明公开
    COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY 审中-公开
    化合物和组合物GPR119活性调节剂

    公开(公告)号：EP2271619A1

    公开(公告)日：2011-01-12

    申请号：EP09729907.7

    申请日：2009-04-03

    申请人： IRM LLC

    发明人： COW, Christopher ,  EPPLE, Robert

    IPC分类号： C07D211/44 ,  C07D401/04 ,  C07D401/14 ,  A61P3/04 ,  A61P3/10 ,  A61K31/497

    CPC分类号： C07D401/14 ,  C07D211/44 ,  C07D401/04

    摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119; such as, but not limited to, diabetes, obesity and associated metabolic disorders. Formula (I) is a compound, in which A can have up to 2 ring -CH2- group substituted with -C(O)- and can be partially unsaturated with up to 2 double bonds; Wi and W2 are independently selected from CR10 and N; wherein R10 is selected from hydrogen and C1_6alkyl; Yi is selected from NRn, O and S; wherein Rn is selected from hydrogen and C1_ 6alkyl; Y2 and Y3 are independently selected from CH and N; Y4 is selected from CH2, OCH2 and NR15; wherein R15 is selected from hydrogen and C1_6alkyl; or the pharmaceutically acceptable salts thereof.