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11.发明公开
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公开(公告)号：EP3316885A1
公开(公告)日：2018-05-09
申请号：EP16818645.0
申请日：2016-06-29
申请人： Immunomedics, Inc.
IPC分类号： A61K31/4745 , A61K45/06
CPC分类号： A61K45/06 , A61K47/6803 , A61K47/6849 , A61K47/6853 , A61K47/6855 , A61K47/6863 , C07D491/22
摘要： The present invention concerns improved methods and compositions for preparing SN-38 conjugates of proteins or peptides, preferably immunoconjugates of antibodies or antigen-binding antibody fragments. More preferably, the SN-38 is attached to the antibody or antibody fragment using a CL2A linker, with 1-12, more preferably 6-8, alternatively 1-5 SN-38 moieties per antibody or antibody fragment. Most preferably, the immunoconjugate is prepared in large scale batches, with various modifications to the reaction scheme disclosed herein to optimize yield and recovery in large scale. Other embodiments concern optimized dosages and/or schedules of administration of immunoconjugate to maximize efficacy for disease treatment and minimize side effects of administration.
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13.发明公开COMBINING RADIOIMMUNOTHERAPY AND ANTIBODY-DRUG CONJUGATES FOR IMPROVED CANCER THERAPY 审中-公开RADIO免疫治疗和抗体药物共轭物的改进癌症治疗相结合
公开(公告)号：EP2506881A1
公开(公告)日：2012-10-10
申请号：EP10835036.4
申请日：2010-12-01
申请人： Immunomedics, Inc.
CPC分类号： A61K39/00 , A61K31/7068 , A61K41/0038 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K51/1045 , A61K51/1057 , A61K2039/507
摘要： Described herein are compositions and methods of use of radionuclide-antibody conjugates (for RAIT) and drug-antibody conjugates (ADC). The combination of RAIT and ADC was more efficacious than either RAIT alone, ADC alone, or the sum of effects of RAIT and ADC. The unexpected synergy resulted in decreased tumor growth rate and increased survival, with a high incidence of tumor-free survival in Capan-1 human pancreatic cancer xenografts in nude mice.
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公开(公告)号：EP3024460A2
公开(公告)日：2016-06-01
申请号：EP14828674.3
申请日：2014-04-17
申请人： Immunomedics, Inc.
IPC分类号： A61K31/4745 , A61K39/395 , A61K47/48
摘要： The present invention concerns improved methods and compositions for preparing SN-38 conjugates of proteins or peptides, preferably immunoconjugates of antibodies or antigen-binding antibody fragments. More preferably, the SN-38 is attached to the antibody or antibody fragment using a CL2A linker, with 1-12, more preferably 6 or less, most preferably 1-5 SN-38 moieties per antibody or antibody fragment. Most preferably, the immunoconjugate is prepared in large scale batches, with various modifications to the reaction scheme to optimize yield and recovery in large scale. Other embodiments concern optimized dosages and/or schedules of administration of immunoconjugate to maximize efficacy for disease treatment and minimize side effects of administration.
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公开(公告)号：EP2271359A2
公开(公告)日：2011-01-12
申请号：EP09707839.8
申请日：2009-02-05
申请人： Immunomedics, Inc.
IPC分类号： A61K39/00
CPC分类号： A61K45/06 , A61K47/60 , A61K47/6803 , A61K47/6839 , A61K47/6841 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6863 , A61K47/6865 , A61K47/6867 , A61K47/6869 , A61K47/6889 , A61K2039/505 , C07K16/1063 , C07K16/2803 , C07K16/2833 , C07K16/2863 , C07K16/30 , C07K2317/73 , Y02A50/403
摘要： The invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a camptothecin as a therapeutic moiety, and further relates to processes for making and using the said conjugates.
摘要翻译： 本发明涉及具有改善的靶向各种患病细胞（包含靶向部分（例如抗体或抗体片段），接头和喜树碱）作为治疗部分的能力的治疗性缀合物，并且还涉及制备和使用所述缀合物 。
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16.发明授权
公开(公告)号：EP0837696B1
公开(公告)日：2010-02-24
申请号：EP96918023.1
申请日：1996-06-07
申请人： Immunomedics, Inc.
IPC分类号： A61K47/48 , A61K51/10 , A61P35/00 , A61P9/00 , A61P31/00 , A61P37/06 , A61P29/00 , A61K39/395 , A61K41/00
CPC分类号： B82Y5/00 , A61K41/0095 , A61K47/665 , A61K47/6893 , A61K47/6897 , A61K47/6898 , A61K49/0017 , A61K51/1078 , A61K51/1093 , A61K2121/00 , A61K2123/00 , G01N33/531 , G01N33/534 , G01N33/574 , G01N33/686 , Y10S424/90
摘要： An in vivo method for delivering a diagnostic or therapeutic agent to a target site in a mammal, wherein a targeting species including a targeting moiety and a diagnostic or therapeutic agent or a binding site for a subsequently administered diagnostic or therapeutic agent conjugate, the targeting moiety having a primary binding site whereby it specifically binds to the target, is administered and allowed to accrete at the target site, is improved by injecting into the circulatory system of the mammal a clearing agent that binds to the primary binding site of the targeting species, whereby non-localized primary targeting species is cleared from circulation. The method is especially useful in pretargeting methods because the clearing agent does not remove the primary targeting species or block secondary binding sites of the primary targeting species.
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17.发明公开POLYMERIC CARRIERS OF THERAPEUTIC AGENTS AND RECOGNITION MOIETIES FOR ANTIBODY-BASED TARGETING OF DISEASE SITES 审中-公开治疗剂和认可聚合物载体仍然是对抗体BASIS疾病点的有针对性的治疗
公开(公告)号：EP2121030A2
公开(公告)日：2009-11-25
申请号：EP07869623.4
申请日：2007-12-20
申请人： Immunomedics, Inc.
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/556 , A61K47/61 , A61K47/6425 , A61K47/645 , A61K47/65 , A61K47/665 , A61K47/6835 , A61K47/6897 , A61K47/6951
摘要： The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may be conjugated to a peptide moiety that contains one or more haptens, such as HSG. The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. Methods for synthesizing and using such therapeutic-loaded polymers and their conjugates are provided.
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