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公开(公告)号：EP3473296A1
公开(公告)日：2019-04-24
申请号：EP18190065.5
申请日：2012-06-28
发明人： BRODERICK, Kate , KEMMERRER, Stephen , MCCOY, Jay
摘要： The disclosure is directed to a device for electroporating and delivering one or more antigens and a method of electroporating and delivering one or more antigens to cells of epidermal tissues using the device. The device comprises a housing, a plurality of electrode arrays projecting from the housing, each electrode array including at least one electrode, a pulse generator electrically coupled to the electrodes, a programmable microcontroller electrically coupled to the pulse generator, and an electrical power source coupled to the pulse generator and the microcontroller. The electrode arrays define spatially separate sites.
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公开(公告)号：EP2542300A1
公开(公告)日：2013-01-09
申请号：EP11751208.7
申请日：2011-03-01
发明人： BRODERICK, Kate , MCCOY, Jay , KEMMERRER, Stephen V , LIN, Feng , KJEKEN, Rune
IPC分类号： A61N1/32
CPC分类号： A61N1/327 , A61K39/12 , A61K39/145 , A61K2039/53 , A61K2039/54 , A61N1/0502 , C12N2760/16134
摘要： A novel electroporation device for the delivery of vaccines that is both effective in generating a protective immune response and tolerable delivery to a subject (or near painless); and also methods of using same device to vaccinate a subject against a variety of infectious diseases and types of cancer in a near painless.
摘要翻译： 一种用于递送疫苗的新型电穿孔装置，其既有效地产生保护性免疫应答，又可耐受递送至受试者（或接近无痛）; 以及使用相同装置在接近无痛的情况下针对各种感染性疾病和癌症类型接种受试者的方法。
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14.发明公开
公开(公告)号：EP4238607A2
公开(公告)日：2023-09-06
申请号：EP23187369.6
申请日：2017-09-22
发明人： FISHER, Paul , BRODERICK, Kate , MCCOY, Jay
IPC分类号： A61N1/04
摘要： A method and device for electroporating adipocytes in the adipose layer of tissue, where the device includes a frame, a first electrode coupled to the frame having a first contact surface, a second electrode coupled to the frame having a second contact surface, and where the first contact surf ace and the second contact surf ace define a treatment zone therebetween. The method including positioning a fold of tissue between the first and second electrodes such that the treatment zone formed between the two electrodes includes an adipose layer of tissue and no skeletal muscle.
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15.发明公开
公开(公告)号：EP3515549A1
公开(公告)日：2019-07-31
申请号：EP17853993.8
申请日：2017-09-22
发明人： FISHER, Paul , BRODERICK, Kate , MCCOY, Jay
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16.发明公开
公开(公告)号：EP3448993A1
公开(公告)日：2019-03-06
申请号：EP17790648.4
申请日：2017-05-01
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公开(公告)号：EP2542300B1
公开(公告)日：2016-08-10
申请号：EP11751208.7
申请日：2011-03-01
发明人： BRODERICK, Kate , MCCOY, Jay , KEMMERRER, Stephen V , LIN, Feng , KJEKEN, Rune
IPC分类号： A61N1/32
CPC分类号： A61N1/327 , A61K39/12 , A61K39/145 , A61K2039/53 , A61K2039/54 , A61N1/0502 , C12N2760/16134
摘要： A novel electroporation device for the delivery of vaccines that is both effective in generating a protective immune response and tolerable delivery to a subject (or near painless); and also methods of using same device to vaccinate a subject against a variety of infectious diseases and types of cancer in a near painless.
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公开(公告)号：EP2726145A1
公开(公告)日：2014-05-07
申请号：EP12846201.7
申请日：2012-06-28
发明人： BRODERICK, Kate , KEMMERRER, Stephen , MCCOY, Jay
IPC分类号： A61N1/30
CPC分类号： A61N1/327 , A61K2039/53 , A61M2037/0007 , A61N1/0412 , A61N1/0424 , A61N1/0476 , C12M35/02 , C12N15/87
摘要： The disclosure is directed to a device for electroporating and delivering one or more antigens and a method of electroporating and delivering one or more antigens to cells of epidermal tissues using the device. The device comprises a housing, a plurality of electrode arrays projecting from the housing, each electrode array including at least one electrode, a pulse generator electrically coupled to the electrodes, a programmable microcontroller electrically coupled to the pulse generator, and an electrical power source coupled to the pulse generator and the microcontroller. The electrode arrays define spatially separate sites.
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19.发明公开
公开(公告)号：EP4238607A3
公开(公告)日：2023-11-08
申请号：EP23187369.6
申请日：2017-09-22
发明人： FISHER, Paul , BRODERICK, Kate , MCCOY, Jay
摘要： A method and device for electroporating adipocytes in the adipose layer of tissue, where the device includes a frame, a first electrode coupled to the frame having a first contact surface, a second electrode coupled to the frame having a second contact surface, and where the first contact surf ace and the second contact surf ace define a treatment zone therebetween. The method including positioning a fold of tissue between the first and second electrodes such that the treatment zone formed between the two electrodes includes an adipose layer of tissue and no skeletal muscle.
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公开(公告)号：EP4121161A1
公开(公告)日：2023-01-25
申请号：EP21770546.6
申请日：2021-03-19
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