公开(公告)号：EP1349645A1

公开(公告)日：2003-10-08

申请号：EP01998392.3

申请日：2001-11-17

申请人： Intech Thüringen GmbH

发明人： SCHMAUDER, Hans-Peter ,  SCHUNK, Werner ,  BRUDER, Michael ,  HEIBER, Uwe ,  KRAUSE, Karl-Heinz ,  MERKMANN, Gerhard

IPC分类号： B01D71/02 ,  A61M1/14 ,  A61M1/16

CPC分类号： B01J20/28033 ,  A61M1/3679 ,  B01D61/00 ,  B01D69/141 ,  B01D71/028 ,  B01J20/186 ,  B01J20/28026 ,  B01J2220/46

摘要： The invention relates to a material for limited selective adsorption and/or absorption of endogenic substances in the blood which have a harmful effect on metabolism when they exceed the corresponding norms. Said material comprises at least the following: a blood-permeable and blood-compatible matrix (2), especially in the form of a membrane (1); and a support, which is incorporated into the matrix (2) or is treated in relation to the matrix and which is loaded with at least one endogenic substance (X) and with an antithrombotic agent (Y), hereby forming a support/substance/antithrombotic agent adduct (3), the concentration of the loaded endogenic substance (X) being below its normal value, so that due to the concentration gradient of this substance within the blood (4) and matrix (2) system, the substance (X') that is harmful to metabolism is adsorbed/absorbed until the normal level is re-established. At the same time, the antithrombotic agent (Y) is released by desorption. The inventive material is characterised in that the support is a molecular sieve which also forms a molecular sieve/substance/antithrombotic agent adduct (3), said adduct additionally containing water of crystallisation, in such a way that the molecular sieve is partially dehydrated with reference to a sufficient basic molar quantity (m) of water of crystallisation. The molecular sieve with the reduced molar quantity (m') of water of crystallisation is loaded with the endogenic substance (X) and the antithrombotic agent (Y), so that when the matrix (2) comes into contact with the blood, water is adsorbed and the antithrombotic agent is desorbed, whereby the water of crystallisation content of the molecular sieve increases. The invention also relates to an advantageous method for producing the inventive material.

公开(公告)号：EP1402586A2

公开(公告)日：2004-03-31

申请号：EP02717973.8

申请日：2002-02-22

申请人： Intech Thüringen GmbH

发明人： BRUDER, Michael ,  HEIBER, Uwe ,  KRAUSE, Karl-Heinz ,  MERKMANN, Gerhard

IPC分类号： H01M2/00

CPC分类号： H01M8/1016

摘要： The invention relates to a fuel cell (1) that comprises at least one of the following components: a proton-conducting membrane (2) as the electrolyte; catalyst layers (3) that cover both sides of the membrane (2); gas-permeable electrodes in the form of an anode (4) and a cathode (5) that rest against the outward-facing surface of the catalyst layers (3); electroconductive plates (6) that come into electroconductive contact with the electrodes at close intervals and that delimit together with the electrodes channels carrying gas; and gas connections for the supply of hydrogen (H2) and oxygen (O2), respectively. The inventive fuel cell (1) is further characterized in that the membrane (2) is a crystalline or polycrystalline thin-film membrane. The thin-film membrane preferably consist of at least one layer (7) from a metal material combined with at least one electrically insulating layer (8).

公开(公告)号：EP1331848A1

公开(公告)日：2003-08-06

申请号：EP01982123.0

申请日：2001-09-19

申请人： Intech Thüringen GmbH

发明人： SCHUNK, Werner ,  BRUDER, Michael ,  GIESSMANN, Konrad ,  KRAUSE, Karl-Heinz ,  MERKMANN, Gerhard ,  HUPE, Gerhard

IPC分类号： A01N25/08 ,  C08K3/34 ,  C08K9/12

CPC分类号： A01N25/08

摘要： The invention relates to a material used for producing products (1) having disinfecting and/or antifungal properties. Said material has at least one matrix (2), in which a molecular sieve is incorporated. Said molecular sieve is loaded with: at least one active substance (Z) having a disinfecting and/or antifungal effect; or at least one first active substance (Z1) having a disinfecting effect and a second active substance (Z2) having an antifungal effect. The corresponding molecular sieve/active substance adduct (3) releases the active substance(s) in conjunction with the aqueous body fluid when the matrix (2) is in contact with a body surface (4) of the human, animal or plant type. The inventive material is characterized in that the molecular sieve/active substance adduct (3) additionally contains water of crystallization to such an extent that the molecular sieve is partially dehydrated with regard to a sufficient basic molar quantity (m) of water of crystallization. The molecular sieve is loaded with the reduced molar quantity (m') of water of crystallization with the active substance(s) (Z, Z1, Z2) so that an adsorption of water with the desorption of the corresponding active substance occurs when the matrix (2) is in contact with the body surface (4), whereby the water of crystallization of the molecular sieve increases. The invention also relates to an advantageous method for producing the inventive active substance.

公开(公告)号：EP1328306A2

公开(公告)日：2003-07-23

申请号：EP01982122.2

申请日：2001-09-19

申请人： Intech Thüringen GmbH

发明人： SCHUNK, Werner ,  BRUDER, Michael ,  GIESSMANN, Konrad ,  KRAUSE, Karl-Heinz ,  MERKMANN, Gerhard

IPC分类号： A61M1/14

CPC分类号： A61K9/0024 ,  A61K9/143

摘要： The invention relates to a material for producing products (1) having fibrinolytic and/or antibacterial properties. Said material has at least one matrix (2), which is compatible with body tissue and in which a molecular sieve is incorporated. Said molecular sieve is loaded with: at least one active substance (Z) having a fibrinolytic or antibacterial effect; or at least one first active substance (Z1) having a fibrinolytic effect and a second active substance (Z2) having an antibacterial effect. The corresponding molecular sieve/active substance adduct (3) releases the active substance(s) in conjunction with the aqueous body fluid when the matrix (2) is in contact with the body tissue (4). The inventive material is characterized in that the molecular sieve/active substance adduct (3) additionally contains water of crystallization to such an extent that the molecular sieve is partially dehydrated with regard to a sufficient basic molar quantity (m) of water of crystallization. The molecular sieve is loaded with the reduced molar quantity (m') of water of crystallization with the active substance(s) (Z, Z1, Z2) so that an adsorption of water with the desorption of the corresponding active substance occurs when the matrix (2) is in contact with the body tissue (4), whereby the water of crystallization of the molecular sieve increases. The invention also relates to an advantageous method for producing the inventive active substance.

公开(公告)号：EP1267845A1

公开(公告)日：2003-01-02

申请号：EP01919140.2

申请日：2001-02-23

申请人： Intech Thüringen GmbH

发明人： SCHUNK, Werner ,  BRUDER, Michael ,  GIESSMANN, Konrad ,  KRAUSE, Karl-Heinz ,  MERKMANN, Gerhard

IPC分类号： A61K9/70

CPC分类号： A61K9/7038

摘要： The invention relates to a plaster containing an active agent (1), comprising at least one cover membrane (2) and an active membrane (3) which is based on a skin-compatible matrix (4) containing a molecular sieve which is loaded with at least one active agent (Z, Z1, Z2). The molecular sieve/active agent adduct (5) releases the active agent when the active membrane comes into contact with the skin (6), in conjunction with the transpired water of the skin. The inventive plaster (1) is characterised in that the molecular sieve/active agent adduct (5) also contains water of crystallisation, to the extent that the molecular sieve is partially dehydrated compared to a sufficient basic molar quantity (m) of water of crystallisation, said molecular sieve with the reduced molar quantity (m') of water of crystallisation being loaded with the active agent (Z, Z1, Z2) so that when the active membrane (3) comes into contact with the skin (6), water is adsorbed and the active agent is desorbed, whereupon the water of crystallisation content of the molecular sieve increases. The invention also relates to various suitable embodiments of the plaster (1) containing an active agent and to an advantageous method for producing the inventive plaster (1) containing an active agent (1).

公开(公告)号：EP1228548B1

公开(公告)日：2004-03-24

申请号：EP00967596.8

申请日：2000-09-20

申请人： Intech Thüringen GmbH

发明人： BRUDER, Michael ,  HEIBER, Uwe ,  KRAUSE, Karl-Heinz ,  MERKMANN, Gerhard

IPC分类号： H01M8/10

CPC分类号： H01M8/1023 ,  C08J5/2231 ,  C08J2327/24 ,  H01M8/0293 ,  H01M8/1051 ,  H01M8/1072 ,  Y02P70/56

公开(公告)号：EP1374324A2

公开(公告)日：2004-01-02

申请号：EP02716614.9

申请日：2002-02-22

申请人： Intech Thüringen GmbH

发明人： SCHMAUDER, Hans-Peter ,  SCHUNK, Werner ,  BRUDER, Michael ,  HEIBER, Uwe ,  KRAUSE, Karl-Heinz ,  MERKMANN, Gerhard

IPC分类号： H01M2/00

CPC分类号： H01M8/1016

摘要： The invention relates to a fuel cell (1) comprising at least the following parts: a proton-conducting membrane (2) serving as an electrolyte; catalyst layers (3), which cover the membrane (2) on both sides; gas permeable electrodes provided in the form an anode (4) and cathode (5), which rest on the outwardly pointing surface of the catalyst layers (3); electrically conductive plates (6), which contact the electrodes in an electrically conductive manner while being located at small distances from one another, and which, together with the electrodes, delimit gas-conducting channels, and; gas connections for supplying hydrogen (H2) on one side and oxygen (O2) on the other. The inventive fuel cell (1) is characterized in that the membrane (2) is a hybrid membrane comprising a matrix into which a channel-forming protein is mixed. The invention also relates to advantageous variants of the membrane (2) in which the matrix, for example, contains a molecular sieve/protein adduct.

公开(公告)号：EP1330639A1

公开(公告)日：2003-07-30

申请号：EP01992880.3

申请日：2001-10-19

申请人： Intech Thüringen GmbH

发明人： BLÜMICH, Bernhard ,  SCHUNK, Werner ,  BRUDER, Michael ,  KRAUSE, Karl-Heinz ,  MERKMANN, Gerhard

IPC分类号： G01N24/08 ,  G01R33/28 ,  A61K9/70 ,  A61L33/00

CPC分类号： A61K49/1893 ,  A61K49/105 ,  A61K49/12

摘要： The invention relates to a material comprising at least the following: a matrix (2), especially with a polymer base; a support which is worked into said matrix. The material data can be detected by means of an NMR device (5). The inventive material is characterized in that the support is loaded with at least one active agent (Z) and with a contrast agent (X), these forming a support/active agent/contrast agent adduct (3); and in that the distribution of the adduct (3) and therefor, the active agent (Z) in the matrix (2), can be measured using the NMR device (5). The support is preferably a molecular sieve. The invention also relates to an advantageous method for producing the inventive material.

公开(公告)号：EP1163508B1

公开(公告)日：2002-12-11

申请号：EP00943825.0

申请日：2000-06-16

申请人： Intech Thüringen GmbH ,  Blümich, Bernhard

发明人： BLÜMICH, Bernhard ,  BRUDER, Michael ,  GUERLIN, Thomas ,  PRADO, Pablo

IPC分类号： G01N24/08 ,  G01R33/38 ,  G01R33/44

CPC分类号： G01R33/28 ,  G01N24/085

摘要： The invention relates to a device for inspecting flat goods made of polymeric materials with embedded textile strength supports with which the arrangement and the progression of the strength supports in the polymeric material can be determined in a nondestructive manner and without derogating the quality of the flat goods. According to the invention, NMR-MOUSE probes are used for conducting a nuclear magnetic analysis of the flat goods. The NMR-MOUSE probes (9a, 9b, 9c) form a measuring plane on a measuring body (1) on which the flat good (3) is placed, and are arranged in the measuring plane (6) such that they overlap with one another preferably in the direction of the material in which the inspection is conducted.