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公开(公告)号:EP0768317B1
公开(公告)日:1999-01-27
申请号:EP96116414.2
申请日:1996-10-14
发明人: Mizukami, Tamio , Asai, Akira , Yamashita, Yoshinori , Katahira, Ritsuko , Hasegawa, Atsuhiro , Ochiai, Keiko , Akinaga, Shiro
CPC分类号: C07K5/06026 , A61K38/00
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12.Interleukin-1 inhibiting manumycin derivatives and streptomyces strains for their production 失效
标题翻译: 白介素1-bildungshemmende Manumycinderivate und Streptomyces-Stämmefürihre Produktion公开(公告)号:EP0705827A1
公开(公告)日:1996-04-10
申请号:EP95306883.0
申请日:1995-09-29
发明人: Tanaka, Takeo , Tsukuda, Eiji , Ochiai, Keiko , Ando, Katsuhiko , Kondo, Hidemasa , Uosaki, Youichi , Saitoh, Yutaka , Matsuda, Yuzuru , Koizumi, Fumito , Agatsuma, Tsutomu
IPC分类号: C07D303/46 , A61K31/335 , C12N1/20
CPC分类号: C12R1/465 , C07D303/46 , C12P17/02
摘要: Provided is an Interleukin-1 production inhibiting compound represented by formula (I)
wherein R denotes 4-methyl-1-pentenyl, 3-methyl-1-pentenyl or 1-methylpentyl.摘要翻译: 提供了由式(I)表示的白细胞介素-1产生抑制化合物
,其中R表示4-甲基-1-戊烯基,3-甲基-1-戊烯基或1-甲基戊基。 -
13.Novel D-amidase and process for producing D-alpha-alanine and/or L-alpha-alanineamide 失效
标题翻译: D-酰胺酶和用于生产D-α-丙氨酸和/或L-α-丙氨酸酰胺的方法。公开(公告)号:EP0334358B1
公开(公告)日:1994-03-16
申请号:EP89105251.6
申请日:1989-03-23
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14.Novel D-amidase and process for producing D-alpha-alanine and/or L-alpha-alanineamide 失效
标题翻译: 新型D-氨基酸和生产D-阿尔法 - 阿兰和/或L-阿尔法 - 阿兰酰胺的方法公开(公告)号:EP0334358A3
公开(公告)日:1989-11-29
申请号:EP89105251.6
申请日:1989-03-23
发明人: Ozaki, Akio , Kawasaki, Hideki , Hashimoto, Yukio , Tamura, Keishiro , Ochiai, Keiko , Kawamoto, Isao
摘要: A novel D-amidase is described. The enzyme specifically hydrolyzes D-α-alanineamide into D-α-alanine. It is produced by culturing a microorganism belonging to the genus Arthrobacter , and is useful as an enzyme for efficiently producing D-α-alanine having a high optical purity and/or L-α-alanineamide from DL-α-alanineamide or D-α-alanineamide at low cost.
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