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    Process for producing cis-3-hydroxy-L-proline
    2.
    发明公开
    Process for producing cis-3-hydroxy-L-proline 失效
    Verfahren zur Herstellung von cis-3-Hydroxy-L-Prolin。

    公开(公告)号：EP0645457A2

    公开(公告)日：1995-03-29

    申请号：EP94113948.7

    申请日：1994-09-06

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Ozaki, Akio ,  Mori, Hideo ,  Shibasaki, Takeshi ,  Ando, Katsuhiko ,  Ochiai, Keiko ,  Chiba, Shigeru ,  Uosaki, Yoichi

    IPC分类号： C12P13/24 ,  C12N9/02

    CPC分类号： C12N9/0071 ,  C12P13/24 ,  C12Y114/11002

    摘要： Provided is a process for industrially producing cis-3-hydroxy-L-proline useful as a raw material for medicines or as an additive to foods. L-proline is converted into cis-3-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Streptomyces or Bacillus and which catalyzes hydroxylation of L-proline into cis-3-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced cis-3-hydroxy-L-proline is recovered from the aqueous medium. Also provided is a novel enzyme L-proline-3-hydroxylase, which is useful for the process.

    摘要翻译： 提供了用作工业上用作药物原料或作为食品添加剂的顺式-3-羟基-L-脯氨酸的方法。 在衍生自属于链霉菌属或芽孢杆菌属的微生物的酶源的存在下，L-脯氨酸转化为顺式-3-羟基-L-脯氨酸，其催化L-脯氨酸羟基化为顺式-3-羟基-L-脯氨酸， L-脯氨酸，二价铁离子和2-酮戊二酸，在水性介质中回收生成的顺式-3-羟基-L-脯氨酸。 还提供了一种新的L-脯氨酸-3-羟化酶，其可用于该方法。

    Process for producing optically active 4-hydroxy-2-ketoglutaric acids
    4.
    发明公开
    Process for producing optically active 4-hydroxy-2-ketoglutaric acids 失效
    4-Hydroxy-2-Ketoglutarsäuren的Verfahren zur Herstellung von optisch-aktiven

    公开(公告)号：EP1045029A2

    公开(公告)日：2000-10-18

    申请号：EP00117178.4

    申请日：1995-03-01

    申请人： KYOWA HAKKO KOGYO CO., Ltd.

    发明人： Katsumata, Ryoichi ,  Hashimoto, Shinichi ,  Ochiai, Keiko

    IPC分类号： C12P7/50 ,  C12P13/24 ,  C12N1/20 ,  C12R1/41

    CPC分类号： C12R1/41 ,  C12P7/50 ,  Y10S435/822 ,  Y10S435/874 ,  Y10S435/877

    摘要： A process for producing an optically active L-4-hydroxy-2-ketoglutaric acid comprises:

    (a) allowing glyoxylic acid and pyruvic acid to coexist with a biocatalyst which is selected from cells, a culture and processed cells of a microorganism belonging to the genus Pseudomonas, Paracoccus, Providencia, Rhizobium or Morganella and having an activity of forming the optically active L-4-hydroxy-2-ketogutaric acid from pyruvic acid and glyoxylic acid in an aqueous medium, thereby to convert the glyoxylic acid and pyruvic acid into the optically active L-4-hydroxy-2-ketoglutaric acid; and
    (b) recovering the optically active L-4-hydroxy-2-ketoglutaric acid from the aqueous medium.

    摘要翻译： 一种制备光学活性的L-4-羟基-2-酮戊二酸的方法包括：（a）使乙醛酸和丙酮酸与生物催化剂共存，所述生物催化剂选自细胞，培养物和加工细胞，属于 具有在水性介质中从丙酮酸和乙醛酸形成光学活性的L-4-羟基-2-酮戊二酸的活性，从而将乙醛酸和丙酮酸转化为 光学活性的L-4-羟基-2-酮戊二酸; 和（b）从水性介质中回收光学活性的L-4-羟基-2-酮戊二酸。

    Process for producing optically active 4-hydroxy-2-ketoglutaric acids
    6.
    发明公开
    Process for producing optically active 4-hydroxy-2-ketoglutaric acids 失效
    一种制备光学活性4-羟基-2-Ketoglutarsäuren过程。

    公开(公告)号：EP0670371A3

    公开(公告)日：1998-02-18

    申请号：EP95301322.4

    申请日：1995-03-01

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Katsumata, Ryoichi ,  Hashimoto, Shinichi ,  Ochiai, Keiko

    IPC分类号： C12P7/50

    CPC分类号： C12R1/41 ,  C12P7/50 ,  Y10S435/822 ,  Y10S435/874 ,  Y10S435/877

    摘要： The object of the present invention is to provide a method for producing an optically active 4-hydroxy-2-ketoglutaric acid which is industrially applicable and advantageous. The present invention provides a process for producing an optically active 4-hydroxy-2-ketoglutaric acid, which comprises allowing glyoxylic acid and pyruvic acid to coexist with a biocatalyst which has an activity of forming the optically active 4-hydroxy-2-ketoglutaric acid from pyruvic acid and glyoxylic acid in an aqueous medium to convert glyoxylic acid into the optically active 4-hydroxy-2-ketoglutaric acid and recovering the optically active 4-hydroxy-2-ketoglutaric acid from the aqueous medium.

    Process for producing optically active 4-hydroxy-2-ketoglutaric acids
    8.
    发明公开
    Process for producing optically active 4-hydroxy-2-ketoglutaric acids 失效
    4-Hydroxy-2-Ketoglutarsäuren的Verfahren zur Herstellung von optisch-aktiven。

    公开(公告)号：EP0670371A2

    公开(公告)日：1995-09-06

    申请号：EP95301322.4

    申请日：1995-03-01

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Katsumata, Ryoichi ,  Hashimoto, Shinichi ,  Ochiai, Keiko

    IPC分类号： C12P7/50

    CPC分类号： C12R1/41 ,  C12P7/50 ,  Y10S435/822 ,  Y10S435/874 ,  Y10S435/877

    摘要： The object of the present invention is to provide a method for producing an optically active 4-hydroxy-2-ketoglutaric acid which is industrially applicable and advantageous.
    The present invention provides a process for producing an optically active 4-hydroxy-2-ketoglutaric acid, which comprises allowing glyoxylic acid and pyruvic acid to coexist with a biocatalyst which has an activity of forming the optically active 4-hydroxy-2-ketoglutaric acid from pyruvic acid and glyoxylic acid in an aqueous medium to convert glyoxylic acid into the optically active 4-hydroxy-2-ketoglutaric acid and recovering the optically active 4-hydroxy-2-ketoglutaric acid from the aqueous medium.

    摘要翻译： 本发明的目的是提供一种在工业上可应用和有利的光学活性4-羟基-2-酮戊二酸的制备方法。 本发明提供了一种光学活性4-羟基-2-酮戊二酸的制备方法，其包括使乙醛酸和丙酮酸与具有形成光学活性的4-羟基-2-酮戊二酸的活性的生物催化剂共存 由水性介质中的丙酮酸和乙醛酸将乙醛酸转化成光学活性的4-羟基-2-酮戊二酸，并从水性介质中回收光学活性的4-羟基-2-酮戊二酸。