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公开(公告)号：EP2115010B1
公开(公告)日：2011-10-19
申请号：EP08709658.2
申请日：2008-02-28
发明人： JAIN, Sanjay , LAING, Peter , GREGORIADIS, Gregory
IPC分类号： C08B37/00
CPC分类号： C08B37/0006 , B01D15/363 , C08B37/0003
摘要： The present invention relates to process for reducing the endotoxin content of a sample of fermentation broth containing polysialic acid and endotoxin comprising the sequential steps: (i) adding to the sample a base having a pKa of at least 12 to form a basic solution having a pH of at least 12, incubating the solution for a pre - determined time at a pre - determined temperature; and (ii) recovery of PSA, suitably by (iii) passing the sample through an anion - exchange column whereby polysialic acid is absorbed on the ion exchange resin; (iv) washing the column with one washing buffer, whereby polysialic acid remains absorbed on the ion exchange resin; and (v) eluting the polysialic acid from the column using an elution buffer to provide a product solution of polysialic acid having reduced endoto xin content.
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12.发明公开DERIVATISATION OF GRANULOCYTE COLONY-STIMULATING FACTOR 有权DERIVATISIERUNG DES GRANULAZENTENKOLONIESTIMULIERENDEN FAKTORS
公开(公告)号：EP2041167A1
公开(公告)日：2009-04-01
申请号：EP07789047.3
申请日：2007-07-25
发明人： JAIN, Sanjay , LAING, Peter , GREGORIADIS, Gregory
IPC分类号： C07K14/535 , A61K47/48
CPC分类号： A61K47/61 , A61K38/00 , A61K38/1816 , A61K38/193 , A61K38/465 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/575 , C12N9/22 , C12Y301/21001 , Y02A50/473
摘要： A composition comprises a population of polysaccharide derivatives of a protein, wherein the protein is insulin or an insulin-like protein and the polysaccharide is anionic and comprises between 2 and 125 saccharide units, and wherein the population consists substantially only of derivatives of the protein derivatised at the N-terminal of the B-chain.
摘要翻译： 组合物包含蛋白质的多糖衍生物群体，其中所述蛋白质是胰岛素或胰岛素样蛋白质，并且所述多糖是阴离子的并且包含2至125个糖单元，并且其中所述群体基本上仅由衍生的蛋白质的衍生物 在B链的N末端。
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公开(公告)号：EP2836229B1
公开(公告)日：2018-12-05
申请号：EP13715237.7
申请日：2013-04-11
发明人： GABIVOV, Alexander , BELOGUROV, Alexey , PONOMARENKO, Natalia , SMIRNOV, Ivan , BACON, Andrew , GREGORIADIS, Gregory
CPC分类号： A61K9/127 , A61K39/0008 , C07K14/4713
摘要： A composition for the treatment of multiple sclerosis comprises a first myelin basic protein (MBP) peptide linked to a first vector, the first MBP peptide consisting of the amino acid sequence: (R1)a-P1-R2)b wherein P1 is an amino acid sequence having at least 85% identity to an amino acid sequence selected from the group consisting of SEQ ID NOS:1-3; each of R1 and R2 are amino acid sequences independently consisting of from 1 to 10 amino acids; and each of a and b are independently zero or one. Compositions of immunodominant peptides of myelin basic protein are encapsulated in mannosylated liposomes. In a specific embodiment, the compositions comprise mylein basic protein (MBP) peptides MBP(46-62), MBP(124-139), and MBP(147-170).
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公开(公告)号：EP2043692B1
公开(公告)日：2016-05-18
申请号：EP07766363.1
申请日：2007-07-25
IPC分类号： A61K47/48 , C07K17/12 , C07K14/505 , A61K38/18 , A61K47/36
CPC分类号： A61K47/61 , A61K38/00 , A61K38/1816 , A61K38/193 , A61K38/465 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/575 , C12N9/22 , C12Y301/21001 , Y02A50/473
摘要： A composition comprises a population of polysaccharide derivatives of a protein, wherein the protein is insulin or an insulin-like protein and the polysaccharide is anionic and comprises between 2 and 125 saccharide units, and wherein the population consists substantially only of derivatives of the protein derivatised at the N-terminal of the B-chain.
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公开(公告)号：EP2115010A1
公开(公告)日：2009-11-11
申请号：EP08709658.2
申请日：2008-02-28
发明人： JAIN, Sanjay , LAING, Peter , GREGORIADIS, Gregory
IPC分类号： C08B37/00
CPC分类号： C08B37/0006 , B01D15/363 , C08B37/0003
摘要： The present invention relates to process for reducing the endotoxin content of a sample of fermentation broth containing polysialic acid and endotoxin comprising the sequential steps: (i) adding to the sample a base having a pKa of at least 12 to form a basic solution having a pH of at least 12, incubating the solution for a pre - determined time at a pre - determined temperature; and (ii) recovery of PSA, suitably by (iii) passing the sample through an anion - exchange column whereby polysialic acid is absorbed on the ion exchange resin; (iv) washing the column with one washing buffer, whereby polysialic acid remains absorbed on the ion exchange resin; and (v) eluting the polysialic acid from the column using an elution buffer to provide a product solution of polysialic acid having reduced endoto xin content.
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公开(公告)号：EP2043692A2
公开(公告)日：2009-04-08
申请号：EP07766363.1
申请日：2007-07-25
IPC分类号： A61K47/48 , C07K17/12 , C07K14/505 , A61K38/18 , A61K47/36
CPC分类号： A61K47/61 , A61K38/00 , A61K38/1816 , A61K38/193 , A61K38/465 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/575 , C12N9/22 , C12Y301/21001 , Y02A50/473
摘要： A composition comprises a population of polysaccharide derivatives of a protein, wherein the protein is insulin or an insulin-like protein and the polysaccharide is anionic and comprises between 2 and 125 saccharide units, and wherein the population consists substantially only of derivatives of the protein derivatised at the N-terminal of the B-chain.
摘要翻译： 组合物包含蛋白质的多糖衍生物群体，其中所述蛋白质是胰岛素或胰岛素样蛋白质，并且所述多糖是阴离子的并且包含2至125个糖单元，并且其中所述群体基本上仅由衍生的蛋白质的衍生物 在B链的N末端。
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公开(公告)号：EP2043616A1
公开(公告)日：2009-04-08
申请号：EP07766361.5
申请日：2007-07-25
发明人： JAIN, Sanjay , LAING, Peter , GREGORIADIS, Gregory
IPC分类号： A61K9/22 , A61K31/198 , A61K9/20 , A61K31/195
CPC分类号： A61K47/61 , A61K38/00 , A61K38/1816 , A61K38/193 , A61K38/465 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/575 , C12N9/22 , C12Y301/21001 , Y02A50/473
摘要： A composition comprises a population of polysaccharide derivatives of a protein, wherein the protein is insulin or an insulin-like protein and the polysaccharide is anionic and comprises between 2 and 125 saccharide units, and wherein the population consists substantially only of derivatives of the protein derivatised at the N-terminal of the B-chain.
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公开(公告)号：EP1217989B1
公开(公告)日：2005-12-14
申请号：EP00964471.7
申请日：2000-10-02
CPC分类号： A61K9/1272
摘要： An oral vaccine contain liposomes and complexed or, preferably entrapped, DNA operatively encoding an antigen in which the liposomes are formed from components including cationic compounds and zwitterionic phospholipids. The hydrophobic groups within the liposome forming components must include at least one group which is saturated. This is believed to raise the transition temperature, rendering the liposomes more stable when delivered orally. The compositions have been found to give detectable increased in IgA levels, secreted immunoglobulins of importance in efficacious oral vaccine delivery.
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