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11.发明授权AMINOTHIAZOLE MACROCYCLES, THEIR USE AS ANTIBACTERIAL COMPOUNDS AND PROCESSES FOR THEIR PRODUCTION 有权AMINOTHIAZOLMAKROCYCLEN，它们的使用作为抗菌化合物并处理其
公开(公告)号：EP2097423B1
公开(公告)日：2011-03-02
申请号：EP07863118.1
申请日：2007-12-19
申请人： Novartis AG
IPC分类号： C07D513/22 , C12N1/20 , C12P17/14 , A61K31/429 , A61P31/00
CPC分类号： C12P17/185 , C07D513/22 , C12R1/01
摘要： This invention relates to a novel antibiotic compounds, pharmaceutically acceptable salts and to methods for obtaining such compounds.
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公开(公告)号：EP2229386A1
公开(公告)日：2010-09-22
申请号：EP08858696.1
申请日：2008-12-10
申请人： Novartis AG
IPC分类号： C07D417/04 , A61K31/427 , A61P31/00
CPC分类号： C07K5/06139 , A61K38/00 , A61K38/05 , A61K45/06 , C07D417/04 , Y02A50/473
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases particularly bacterial infections.
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公开(公告)号：EP3310771B1
公开(公告)日：2020-07-22
申请号：EP16731665.2
申请日：2016-06-15
申请人： Novartis AG
发明人： CHEN, Zhuoliang , FORTANET, Jorge Garcia , LAMARCHE, Matthew J. , SENDZIK, Martin , TAMEZ, JR., Victoriano , YU, Bing
IPC分类号： C07D401/04 , C07D401/14 , C07D491/107 , A61K31/537 , A61K31/513 , A61K31/4545 , A61P35/00 , A61P9/00 , A61P19/00 , A61P21/00 , A61P25/28
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公开(公告)号：EP3568204A1
公开(公告)日：2019-11-20
申请号：EP18701574.8
申请日：2018-01-08
发明人： DARDAEI ALGHALANDIS, Leila , ENGELMAN, Jeffrey Adam , HAO, Huaixiang , LI, Fang , LAMARCHE, Matthew J. , WANG, Hui-Qin
IPC分类号： A61P35/00 , A61K45/06 , A61K31/4353 , A61K31/4439 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/53 , A61K31/5375
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公开(公告)号：EP3094628B1
公开(公告)日：2018-08-08
申请号：EP15703321.8
申请日：2015-01-16
申请人： Novartis AG
发明人： CHEN, Christine Hiu-tung , CHEN, Zhuoliang , DORE, Michael , FORTANET, Jorge Garcia , KARKI, Rajesh , KATO, Mitsunori , LAMARCHE, Matthew J. , PEREZ, Lawrence Blas , SMITH, Troy Douglas , WILLIAMS, Sarah , GIRALDES, John William , TOURE, Bakary-barry , SENDZIK, Martin
IPC分类号： C07D241/18 , C07D241/20 , A61K31/495 , A61P35/04
CPC分类号： C07D498/10 , C07B2200/07 , C07D241/18 , C07D241/20 , C07D401/04 , C07D401/14 , C07D403/04 , C07D471/10 , C07D491/107 , C07D495/10
摘要： in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
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16.发明公开1 -(TRIAZIN-3-YI_/PYRIDAZIN-3-YL)-PIPER(-AZINE)IDINE DERIVATIVES AND COMPOSITIONS THEREOF FOR INHIBITING THE ACTIVITY OF SHP2 审中-公开1-（3-三嗪yi_ /哒嗪-3-基） - 哌（-AZINE）IDIN衍生物及其组合物用于抑制SHP2的活度
公开(公告)号：EP3094629A1
公开(公告)日：2016-11-23
申请号：EP15703106.3
申请日：2015-01-16
申请人： Novartis AG
发明人： CHEN, Zhuoliang , DORE, Michael , FORTANET, Jorge Garcia , KARKI, Rajesh , KATO, Mitsunori , LAMARCHE, Matthew J. , PEREZ, Lawrence Blas , WILLIAMS, Sarah , SENDZIK, Martin
IPC分类号： C07D249/14 , C07D241/26 , A61K31/495 , A61P35/04
CPC分类号： C07D401/04 , C07D241/26 , C07D249/14 , C07D401/14
摘要： The present invention relates to compounds of formula I: in which Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
摘要翻译： 本发明涉及式I的化合物：其中Y1，Y2，Y3，R1，R 2A，2B，3A，3B，4A，4B，5A，R 5B是本发明的概述中所定义; 能够抑制SHP2的活性。 本发明进一步提供了一种用于本发明的化合物的制备方法，药物制剂，其包括测试的化合物并使用化合物的方法和在与SHP2的异常活性相关的疾病或病症的管理审查的组合物。
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17.发明授权AN AMINOTHIAZOLE DERIVATIVE AS ANTIBACTERIAL AGENT 有权EIN AMINOTHIAZOL DERIVAT UND SEINE VERWENDUNG ALS ANTIBAKTERIELLER WIRKSTOFF
公开(公告)号：EP2229386B1
公开(公告)日：2015-06-03
申请号：EP08858696.1
申请日：2008-12-10
申请人： Novartis AG
IPC分类号： C07D417/04 , A61K31/427 , A61P31/00
CPC分类号： C07K5/06139 , A61K38/00 , A61K38/05 , A61K45/06 , C07D417/04 , Y02A50/473
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases particularly bacterial infections.
摘要翻译： 本申请描述了式（I）的有机化合物及其药物组合物及其用于治疗，预防和/或改善疾病，特别是细菌感染的用途。
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18.发明公开AMINOTHIAZOLE MACROCYCLES, THEIR USE AS ANTIBACTERIAL COMPOUNDS AND PROCESSES FOR THEIR PRODUCTION 有权AMINOTHIAZOLMAKROCYCLEN，它们的使用作为抗菌化合物并处理其
公开(公告)号：EP2097423A2
公开(公告)日：2009-09-09
申请号：EP07863118.1
申请日：2007-12-19
申请人： NOVARTIS AG
IPC分类号： C07D513/22 , C12N1/20 , C12P17/14 , A61K31/429 , A61P31/00
CPC分类号： C12P17/185 , C07D513/22 , C12R1/01
摘要： This invention relates to a novel antibiotic compounds, pharmaceutically acceptable salts and to methods for obtaining such compounds.
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