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1.发明公开NUCLEIC ACID MOLECULE OF A BIOSYNTHETIC CLUSTER ENCODING NON RIBOSOMAL PEPTIDE SYNTHASES AND USES THEREOF 审中-公开FOR非核糖体肽合成酶的核酸分子，其编码的生物合成集群及其用途
公开(公告)号：EP2396344A2
公开(公告)日：2011-12-21
申请号：EP10703647.7
申请日：2010-02-11
申请人： Novartis AG
IPC分类号： C07K14/195 , C07K11/02
摘要： The present invention relates to the provision of a polynucleotide comprising one or more functional fragments of a biosynthetic gene cluster involved in the production of a compound of formula (I) or (I'). The present invention also provides a method of preparing a compound of formula (I) or (I) or of formula (II) to (VII), (XI) to (XIV) and (XVII) and (XVIII). Moreover, the use of such compound as a pharmaceutical composition is also provided in the present invention.
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2.发明授权AMINOTHIAZOLE MACROCYCLES, THEIR USE AS ANTIBACTERIAL COMPOUNDS AND PROCESSES FOR THEIR PRODUCTION 有权AMINOTHIAZOLMAKROCYCLEN，它们的使用作为抗菌化合物并处理其
公开(公告)号：EP2097423B1
公开(公告)日：2011-03-02
申请号：EP07863118.1
申请日：2007-12-19
申请人： Novartis AG
IPC分类号： C07D513/22 , C12N1/20 , C12P17/14 , A61K31/429 , A61P31/00
CPC分类号： C12P17/185 , C07D513/22 , C12R1/01
摘要： This invention relates to a novel antibiotic compounds, pharmaceutically acceptable salts and to methods for obtaining such compounds.
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公开(公告)号：EP2170907A2
公开(公告)日：2010-04-07
申请号：EP08760422.9
申请日：2008-06-03
申请人： Novartis AG
IPC分类号： C07D513/22 , A61K31/429 , A61K31/4353 , A61P31/04
CPC分类号： C07K7/64 , A61K38/12 , A61K45/06 , C07D513/22
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.
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公开(公告)号：EP2183273B1
公开(公告)日：2017-04-05
申请号：EP08803036.6
申请日：2008-08-14
申请人： Novartis AG
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公开(公告)号：EP2183270B1
公开(公告)日：2014-12-17
申请号：EP08803037.4
申请日：2008-08-14
申请人： Novartis AG
CPC分类号： A61K38/15 , A61K38/00 , C07K7/06 , C07K14/811
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公开(公告)号：EP2285808B1
公开(公告)日：2013-11-20
申请号：EP09737965.5
申请日：2009-04-01
申请人： Novartis AG
发明人： ANG, Shi Hua , KRASTEL, Philipp , LEONG, Seh Yong , TAN, Liying Jocelyn , WONG, Wei Lin Josephine , YEUNG, Bryan KS , ZOU, Bin
IPC分类号： C07D471/20 , C07D487/20 , A61K31/437 , A61K31/55 , A61K31/407 , A61P33/02 , A61P33/06 , A61K31/424 , A61K31/438 , C07D498/22
CPC分类号： C07D471/20 , C07D487/20 , C07D498/22
摘要： The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi and parasites of the Leishmania genus such as, for example, Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.
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公开(公告)号：EP2285808A1
公开(公告)日：2011-02-23
申请号：EP09737965.5
申请日：2009-04-01
申请人： Novartis AG
发明人： ANG, Shi Hua , KRASTEL, Philipp , LEONG, Seh Yong , TAN, Liying Jocelyn , WONG, Wei Lin Josephine , YEUNG, Bryan KS , ZOU, Bin
IPC分类号： C07D471/20 , C07D487/20 , A61K31/437 , A61K31/55 , A61K31/407 , A61P33/02 , A61P33/06 , A61K31/424 , A61K31/438 , C07D498/22
CPC分类号： C07D471/20 , C07D487/20 , C07D498/22
摘要： The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by
Plasmodium falciparum ,
Plasmodium vivax ,
Plasmodium malariae ,
Plasmodium ovale ,
Trypanosoma cruzi and parasites of the
Leishmania genus such as, for example,
Leishmania donovani . The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.-
公开(公告)号：EP2183273A1
公开(公告)日：2010-05-12
申请号：EP08803036.6
申请日：2008-08-14
申请人： Novartis AG
发明人： KRASTEL, Philipp , LIECHTY, Brigitta-Maria , MEINGASSNER, Josef Gottfried , SCHMITT, Esther , SCHREINER, Erwin Paul
摘要： The present application relates to cyclic depsipeptides, or derivatives thereof, having the structure of formula (I), and uses thereof, e.g. as inhibito rs of kallikrein 7 and human neutrophil elastase.
摘要翻译： 本申请涉及具有式（I）结构的环状缩肽或其衍生物，及其用途，例如， 作为激肽释放酶7和人嗜中性粒细胞弹性蛋白酶的抑制剂。
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公开(公告)号：EP2183270A1
公开(公告)日：2010-05-12
申请号：EP08803037.4
申请日：2008-08-14
申请人： Novartis AG
CPC分类号： A61K38/15 , A61K38/00 , C07K7/06 , C07K14/811
摘要： The present application relate to cyclic depsipeptides, or derivatives thereof, having the formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7.
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10.发明公开AMINOTHIAZOLE MACROCYCLES, THEIR USE AS ANTIBACTERIAL COMPOUNDS AND PROCESSES FOR THEIR PRODUCTION 有权AMINOTHIAZOLMAKROCYCLEN，它们的使用作为抗菌化合物并处理其
公开(公告)号：EP2097423A2
公开(公告)日：2009-09-09
申请号：EP07863118.1
申请日：2007-12-19
申请人： NOVARTIS AG
IPC分类号： C07D513/22 , C12N1/20 , C12P17/14 , A61K31/429 , A61P31/00
CPC分类号： C12P17/185 , C07D513/22 , C12R1/01
摘要： This invention relates to a novel antibiotic compounds, pharmaceutically acceptable salts and to methods for obtaining such compounds.
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