公开(公告)号：EP2438069A1

公开(公告)日：2012-04-11

申请号：EP10713603.8

申请日：2010-03-30

申请人： NeuroSearch A/S

发明人： SØRENSEN, Ulrik, Svane ,  ERIKSEN, Birgitte, L. ,  HOUGAARD, Charlotte ,  STRØBÆK, Dorte ,  CHRISTOPHERSEN, Palle

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/28

CPC分类号： C07D487/04

摘要： This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as modulators of potassium channels. In other aspects the invention relates to the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

公开(公告)号：EP2414365A1

公开(公告)日：2012-02-08

申请号：EP10712059.4

申请日：2010-03-30

申请人： NeuroSearch A/S

发明人： SØRENSEN, Ulrik, Svane ,  ERIKSEN, Birgitte, L. ,  HOUGAARD, Charlotte ,  STRØBÆK, Dorte ,  CHRISTOPHERSEN, Palle

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/28

CPC分类号： C07D487/04

摘要： This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as modulators of potassium channels. In other aspects the invention relates to the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

公开(公告)号：EP2203436A1

公开(公告)日：2010-07-07

申请号：EP08804249.4

申请日：2008-09-16

申请人： NeuroSearch A/S

发明人： ERIKSEN, Birgitte, L. ,  SØRENSEN, Ulrik, Svane ,  HOUGAARD, Charlotte ,  PETERS, Dan ,  CHRISTOPHERSEN, Palle

IPC分类号： C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D417/04 ,  A61K31/497 ,  A61P25/08

CPC分类号： C07D403/04 ,  C07D401/04 ,  C07D405/14 ,  C07D417/04

摘要： This invention relates to novel pyrazine derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

公开(公告)号：EP2142545A1

公开(公告)日：2010-01-13

申请号：EP08735523.6

申请日：2008-03-27

申请人： NeuroSearch A/S

发明人： ERIKSEN, Birgitte, L. ,  SØRENSEN, Ulrik, Svane ,  HOUGAARD, Charlotte ,  PETERS, Dan ,  JOHANSEN, Tina, Holm ,  CHRISTOPHERSEN, Palle

IPC分类号： C07D473/16 ,  A61K31/52 ,  A61P9/00 ,  A61P11/00

CPC分类号： C07D473/16 ,  C07D473/24

摘要： This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

公开(公告)号：EP2074113A1

公开(公告)日：2009-07-01

申请号：EP07820871.7

申请日：2007-10-03

申请人： NeuroSearch A/S

发明人： ERIKSEN, Birgitte, L. ,  SØRENSEN, Ulrik, Svane ,  HOUGAARD, Charlotte ,  TEUBER, Lene ,  PETERS, Dan ,  CHRISTOPHERSEN, Palle ,  JOHANSEN, Tina, Holm

IPC分类号： C07D403/04 ,  A61K31/4439 ,  C07D401/04 ,  A61K31/506 ,  A61P9/00

CPC分类号： C07D403/04 ,  C07D401/04

摘要： This invention relates to novel indazolyl derivatives of formula (Ia) and (Ib) useful as potassium channel modulating agents, and their use in the preparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium- channels, in particular respiratory diseases, epilepsy, convulsions, seizures, absence seizures, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, erectile dysfunction, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart, disease, angina pectoris, coronary heart disease, autism, ataxia, traumatic brain injury, Parkinson's disease, bipolar disorder, psychosis, schizophrenia, anxiety, depression, mania, mood disorders, dementia, memory and attention deficits, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), dysmenorrhea,narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, arrhythmia, hypertension, myotonic muscle' dystrophia, spasticity, xerostomi, diabetes type II, hypehnsulinemia, premature labour, baldness, cancer, irritable bowel syndrome, immune suppression, migraine and pain.

公开(公告)号：EP2066655A2

公开(公告)日：2009-06-10

申请号：EP07803273.7

申请日：2007-09-06

申请人： NeuroSearch A/S

发明人： ERIKSEN, Birgitte, L. ,  SØRENSEN, Ulrik, Svane ,  HOUGAARD, Charlotte ,  TEUBER, Lene ,  PETERS, Dan ,  CHRISTOPHERSEN, Palle ,  JOHANSEN, Tina, Holm

IPC分类号： C07D401/04 ,  A61K31/506 ,  A61P11/00

CPC分类号： C07D401/04

摘要： This invention relates to novel pyridinyl-pyrimidine derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels. Formula (I).

公开(公告)号：EP1963284A1

公开(公告)日：2008-09-03

申请号：EP06830421.1

申请日：2006-12-06

申请人： NeuroSearch A/S

发明人： SØRENSEN, Ulrik, Svane ,  ERIKSEN, Birgitte, L. ,  TEUBER, Lene ,  PETERS, Dan ,  STRØBÆK, Dorte ,  JOHANSEN, Tina, Holm ,  CHRISTOPHERSEN, Palle

IPC分类号： C07D239/95 ,  C07D401/04

CPC分类号： C07D239/95 ,  C07D401/04

摘要： Quinazoline-2,4-diamine derivatives of formula (I), pharmaceutical compositions thereof and their use for the modulation of small conductance calcium activated potassium channels (SK channels).