公开(公告)号：EP2475656A1

公开(公告)日：2012-07-18

申请号：EP10748096.4

申请日：2010-09-02

申请人： NeuroSearch A/S

发明人： BROWN, William, Dalby ,  JESSEN, Carsten ,  STRØBÆK, Dorte

IPC分类号： C07D405/14 ,  C07D413/14

CPC分类号： C07D413/14 ,  C07D405/14

摘要： The present application relates to novel substituted aminopyridine derivatives, to their use in therapy, to pharmaceutical compositions comprising the derivatives, to the use of said derivatives in the manufacture of a medicament, and to therapeutic methods comprising the administration of the derivatives. The present derivatives are useful for treating a disorder responsive to activation of K
V 7 channels. Due to the distribution of K
V 7 channels within the organism, K
V 7 channel modulators are considered potentially useful for the treatment or alleviation of conditions as diverse as CNS disorders, psychiatric disorders, CNS damage caused by trauma, stroke or neurodegenerative illness or diseases, a variety of neuronal hyperexcitability disorders and conditions, epilepsy, pain, neuropathic pain, migraine, tension type headache, learning and cognitive disorders, motion and motor disorders, multiple sclerosis, cardiac disorders, heart failure, cardio-myopathia, inflammatory diseases, ophthalmic conditions, deafness, progressive hearing loss, tinnitus, obstructive or inflammatory airway diseases, for inducing or maintaining bladder control including the treatment or prevention of urinary incontinence.

摘要翻译： 本申请涉及新的取代的氨基吡啶衍生物，其在治疗中的用途，包含所述衍生物的药物组合物，所述衍生物在制备药物中的用途，以及包括所述衍生物的施用的治疗方法。 本发明衍生物可用于治疗对K V7通道活化有反应的病症。 由于生物体内K V7通道的分布，K V7通道调节剂被认为可能用于治疗或缓解各种病症，如中枢神经系统疾病，精神疾病，由创伤，中风或神经退行性疾病或疾病引起的CNS损伤， 癫痫症，疼痛，神经性疼痛，偏头痛，紧张型头痛，学习和认知障碍，运动和运动障碍，多发性硬化症，心脏病，心力衰竭，心 - 肌病，炎性疾病，眼科病症， 耳聋，进行性听力丧失，耳鸣，阻塞性或炎性气道疾病，用于诱导或维持膀胱控制，包括治疗或预防尿失禁。

公开(公告)号：EP2094655A1

公开(公告)日：2009-09-02

申请号：EP07857650.1

申请日：2007-12-17

申请人： NeuroSearch A/S

发明人： NARDI, Antonio ,  DEMNITZ, Joachim ,  GRUNNET, Morten ,  CHRISTOPHERSEN, Palle ,  JONES, David Spencer ,  NIELSEN, Elsebet Østergaard ,  STRØBÆK, Dorte ,  MADSEN, Lars Siim

IPC分类号： C07C335/18 ,  C07D257/04 ,  A61K31/17 ,  A61P15/12

CPC分类号： C07D257/04 ,  A61K31/17 ,  A61K31/41 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/53 ,  C07C335/18

摘要： The invention relates to novel biphenyl thio-urea derivatives of Formula (I), wherein A represents hydroxy or tetrazolyl; R1 represents halo, hydroxy or phenyl, which phenyl may optionally be substituted with halo; and R2 and R3, independent of each other, represent halo, trifluoromethyl, nitro and/or phenyl, that are found to be potent modulators of ion channels and, as such, they are valuable candidates for the treatment of disease or disorders as diverse as those which are responsive to modulation of ion channels.

公开(公告)号：EP1940804A2

公开(公告)日：2008-07-09

申请号：EP06807251.1

申请日：2006-10-13

申请人： NeuroSearch A/S

发明人： SØRENSEN, Ulrik, Svane ,  ERIKSEN, Birgitte, L. ,  TEUBER, Lene ,  PETERS, Dan ,  STRØBÆK, Dorte ,  JOHANSEN, Tina, Holm ,  CHRISTOPHERSEN, Palle

IPC分类号： C07D239/48 ,  A61K31/505 ,  A61P25/28

CPC分类号： C07D239/48

摘要： This invention relates to novel pyrimidine-2,4-diamine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

公开(公告)号：EP1838306A1

公开(公告)日：2007-10-03

申请号：EP06701206.2

申请日：2006-01-10

申请人： NEUROSEARCH A/S

发明人： SØRENSEN, Ulrik, Svane ,  TEUBER, Lene ,  PETERS, Dan ,  STRØBÆK, Dorte ,  JOHANSEN, Tina, Holm ,  NIELSEN, Karin, Sandager ,  CHRISTOPHERSEN, Palle

IPC分类号： A61K31/4184 ,  C07D235/30 ,  A61P25/00

CPC分类号： C07D235/30

摘要： This invention relates to novel 2-amino benzimidazole derivatives of formula (I1) and (Ib) useful as modulators of small-conductance calcium-activated potassium channels (SK channels) . In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

公开(公告)号：EP2408747A1

公开(公告)日：2012-01-25

申请号：EP10708196.0

申请日：2010-03-11

申请人： NeuroSearch A/S

发明人： JESSEN, Carsten ,  BROWN, William, Dalby ,  STRØBÆK, Dorte

IPC分类号： C07D213/74 ,  A61K31/444 ,  A61P25/00

CPC分类号： C07D213/74

摘要： The present application discloses novel substituted pyridinyl-methylamine derivatives and their use as modulators of the voltage gated K
v 7 (KCNQ) potassium ion channels. In other aspects the application discloses the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising these compounds.

公开(公告)号：EP1838306B1

公开(公告)日：2010-11-17

申请号：EP06701206.2

申请日：2006-01-10

申请人： NeuroSearch A/S

发明人： SØRENSEN, Ulrik, Svane ,  TEUBER, Lene ,  PETERS, Dan ,  STRØBÆK, Dorte ,  JOHANSEN, Tina, Holm ,  NIELSEN, Karin, Sandager ,  CHRISTOPHERSEN, Palle

IPC分类号： A61K31/4184 ,  C07D235/30 ,  A61P25/00

CPC分类号： C07D235/30

摘要： This invention relates to novel 2-amino benzimidazole derivatives of formula (I1) and (Ib) useful as modulators of small-conductance calcium-activated potassium channels (SK channels) . In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

公开(公告)号：EP2231611A1

公开(公告)日：2010-09-29

申请号：EP08860335.2

申请日：2008-12-10

申请人： NeuroSearch A/S

发明人： BROWN, William, Dalby ,  JESSEN, Carsten ,  STRØBÆK, Dorte

IPC分类号： C07D213/75 ,  C07D405/12 ,  A61K31/44 ,  A61P29/00

CPC分类号： C07D213/75 ,  C07D405/12

摘要： This invention relates to novel 2-pyrrolidinyl-3-amido-6-amino-pyhdine derivatives having medical utility, to use of the 2-pyrrolidinyl-3-amido-6-amino- pyridine derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the 2-pyrrolidinyl-3-amido-6-amino- pyridine derivatives of the invention, and to methods of treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of Kv7 channels.

公开(公告)号：EP2155700A1

公开(公告)日：2010-02-24

申请号：EP08736619.1

申请日：2008-04-29

申请人： NeuroSearch A/S

发明人： NARDI, Antonio ,  CHRISTENSEN, Jeppe, Kejser ,  GRUNNET, Morten ,  CHRISTOPHERSEN, Palle ,  JONES, David, Spencer ,  NIELSEN, Elsebet, Østergaard ,  STRØBÆK, Dorte ,  MADSEN, Lars, Siim

IPC分类号： C07D257/04 ,  A61K31/41 ,  A61P9/00

CPC分类号： C07D257/04

摘要： This invention relates to novel β-keto-amide derivatives that are found to be potent modulators of ion channels, and in particular potassium channels and chloride channels, and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.

摘要翻译： 本发明涉及新的β-酮酰胺衍生物，其被发现是有效的离子通道调节剂，特别是钾通道和氯离子通道，因此它们是治疗各种疾病或病症的有价值的候选者 它们响应于钾通道的调节。

公开(公告)号：EP2001853A1

公开(公告)日：2008-12-17

申请号：EP07727223.5

申请日：2007-03-22

申请人： NeuroSearch A/S

发明人： SØRENSEN, Ulrik, Svane ,  ERIKSEN, Birgitte, L. ,  TEUBER, Lene ,  PETERS, Dan ,  STRØBÆK, Dorte ,  JOHANSEN, Tina, Holm ,  CHRISTOPHERSEN, Palle

IPC分类号： C07D233/46 ,  C07D235/30 ,  C07D239/14 ,  C07D239/84 ,  C07D243/04

CPC分类号： C07D233/46 ,  C07D235/30 ,  C07D239/14 ,  C07D239/84 ,  C07D243/04

摘要： This invention relates to novel guanidine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

公开(公告)号：EP2414364A1

公开(公告)日：2012-02-08

申请号：EP10711887.9

申请日：2010-03-30

申请人： NeuroSearch A/S

发明人： SØRENSEN, Ulrik, Svane ,  ERIKSEN, Birgitte, L. ,  STRØBÆK, Dorte ,  CHRISTOPHERSEN, Palle

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/28

CPC分类号： C07D487/04

摘要： This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines useful as modulators of potassium channels. In other aspects the invention relates to the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention. Formula (I).