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公开(公告)号：EP1909850A2
公开(公告)日：2008-04-16
申请号：EP06788187.0
申请日：2006-07-21
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/3515 , C12N2310/3521
摘要： The invention relates to compositions and methods for modulating the expression of the RhoA gene, and more particularly to the downregulation of RhoA by chemically modified oligonucleotides.
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公开(公告)号：EP1814597A2
公开(公告)日：2007-08-08
申请号：EP05857009.4
申请日：2005-11-23
IPC分类号： A61K48/00
CPC分类号： C12N15/1135 , C12N2310/14 , C12N2310/315 , C12N2310/32 , C12N2310/33
摘要： The invention relates to compositions and methods for modulating the expression of Bcr-Abl, and more particularly to the down-regulation of Bcr-Abl mRNA and Bcr-Abl protein levels by oligonucleotides via RNA interference, e.g., chemically modified oligonucleotides.
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公开(公告)号：EP1765847A2
公开(公告)日：2007-03-28
申请号：EP05780090.6
申请日：2005-05-27
发明人： VORNLOCHER, Hans-Peter , HADWIGER, Philipp , ZIMMERMANN, Tracy, Stage , MANOHARAN, Muthiah , RAJEEV, Kallanthottathil G. , ROEHL, Ingo , AKINC, Akin
CPC分类号： C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231 , C12N2310/53 , C12N2320/51 , C12N2310/3521 , C12N2310/3525 , C12N2310/3527
摘要： This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
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公开(公告)号：EP1635763A2
公开(公告)日：2006-03-22
申请号：EP04776396.6
申请日：2004-06-09
发明人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , BUMCROT, David , FARRER, Matthew, J. , MARAGANORE, Demetrius , VORNLOCHER, Hans-Peter
IPC分类号： A61K6/00
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3517 , C12N2310/3521
摘要： Aspects featured in the invention relate to compositions and methods for inhibiting alpha-synuclein (SNCA) gene expression, such as for the treatment of neurodegenerative disorders. An anti- SNCA agent featured herein that targets the SNCA gene can have been modified to alter distribution in favor of neural cells.
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公开(公告)号：EP2008274B1
公开(公告)日：2015-05-27
申请号：EP07759825.8
申请日：2007-03-30
CPC分类号： C12N15/1138 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3233 , C12N2310/3515 , C12N2330/30 , C12N2310/3521
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公开(公告)号：EP1802644B1
公开(公告)日：2012-11-07
申请号：EP05802154.4
申请日：2005-09-26
IPC分类号： C12N15/113 , C07H21/04 , A61K31/70 , C12N5/00
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/718 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
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17.发明授权
公开(公告)号：EP1841464B1
公开(公告)日：2012-06-27
申请号：EP06733815.2
申请日：2006-01-24
IPC分类号： C12N15/113 , A61P25/00
CPC分类号： C12N15/1136 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515
摘要： The invention relates to compositions and methods for modulating the expression of Nogo-L or Nogo-R genes, and more particularly to the downregulation of Nogo-L or Nogo-R by chemically modified oligonucleotides.
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18.发明授权COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR V LEIDEN MUTANT GENE 有权组合物和方法因子V Leiden突变基因表达抑制
公开(公告)号：EP1945270B1
公开(公告)日：2011-05-25
申请号：EP06837014.7
申请日：2006-11-07
IPC分类号： A61K31/713 , C12N15/11
CPC分类号： C12N15/113 , A61K47/554 , A61K48/00 , C12N2310/14 , C12N2320/30
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor V Leiden mutant gene (Factor V Leiden mutant gene), comprising an antisense strand having a nucleotide sequence which is less than 25 nucleotides in length and which is substantially complementary to at least a part of the Factor V Leiden mutant gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Factor V Leiden mutant gene using the pharmaceutical composition; and methods for inhibiting the expression of the Factor V Leiden mutant gene in a cell.
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公开(公告)号：EP2023937A2
公开(公告)日：2009-02-18
申请号：EP07797577.9
申请日：2007-05-18
IPC分类号： A61K31/70
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/3515
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an Aha gene (Aha1 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an Aha gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Aha1 expression and the expression of an Aha gene using the pharmaceutical composition; and methods for inhibiting the expression of an Aha gene in a cell.
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公开(公告)号：EP1993611A2
公开(公告)日：2008-11-26
申请号：EP07753200.0
申请日：2007-03-15
IPC分类号： A61K48/00
CPC分类号： C12N15/1136 , C12N2310/14 , C12N2310/321 , C12N2310/3521
摘要： The present invention concerns methods of treatment using transforming growth factor beta (TGF-beta) modulators. More specifically, the invention concerns methods of treating disorders associated with undesirable TGF-beta signaling, by administering short interfering RNA which down-regulate the expression of TGF-beta, and agents useful therein.
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