公开(公告)号：EP1838700A2

公开(公告)日：2007-10-03

申请号：EP06700500.9

申请日：2006-01-09

申请人： Novartis AG ,  NOVARTIS-PHARMA GMBH

发明人： FURET, Pascal ,  MARTINY-BARON, Georg ,  MCCARTHY, Clive, Novartis AG ,  RASETTI, Vittorio ,  VAUPEL, Andrea

IPC分类号： C07D403/12 ,  A61K31/496 ,  A61P35/00

CPC分类号： C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14

摘要： The invention relates to compounds of the formula (I), their use as kinase inhibitors, new pharmaceutical formulations comprising said compounds, said compounds for use in the diagnostic or therapeutic treatment of warm-blooded animals, especially humans, their use in the treatment of diseases or for the manufacture of pharmaceutical formulations useful in the treatment of diseases that respond to modulation of kinase activity, methods of treatment comprising administration of said compounds to a warm-blooded animal, especially a human, and processes for the manufacture of said compounds.

公开(公告)号：EP1718651A2

公开(公告)日：2006-11-08

申请号：EP05715376.9

申请日：2005-02-17

申请人： Novartis AG ,  NOVARTIS-PHARMA GMBH

发明人： CARAVATTI, Giorgio ,  VAUPEL, Andrea

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D487/04

摘要： The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula (I), wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives - alone or in combination with one or more other pharmaceutically active compounds - for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.

公开(公告)号：EP1874770A1

公开(公告)日：2008-01-09

申请号：EP06724286.7

申请日：2006-04-12

申请人： Novartis Pharma AG ,  NOVARTIS-PHARMA GMBH

发明人： BOLD, Guido ,  FURET, Pascal ,  GUAGNANO, Vito ,  MCCARTHY, Clive, Novartis AG ,  VAUPEL, Andrea

IPC分类号： C07D471/04 ,  C07D235/04 ,  A61K31/4184 ,  A61K31/4188 ,  A61P35/00 ,  A61P35/02

CPC分类号： C07D235/06 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  C07D473/00

摘要： The invention relates to compounds of the formula (I) wherein the moieties R1 , R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof; as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases.

公开(公告)号：EP4344702A3

公开(公告)日：2024-04-10

申请号：EP24151713.5

申请日：2020-12-17

申请人： Novartis AG

发明人： COTESTA, Simona ,  GERSPACHER, Marc ,  LEBLANC, Catherine ,  LIU, Bo ,  LORTHIOIS, Edwige Liliane Jeanne ,  MACHAUER, Rainer ,  MAH, Robert ,  MURA, Christophe ,  RIGOLLIER, Pascal ,  SCHNEIDER, Nadine ,  STUTZ, Stefan ,  VAUPEL, Andrea ,  WARIN, Nicolas ,  WILCKEN, Rainer

IPC分类号： A61P35/00 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/416

摘要： The present invention provides a compound of formula (I) or a stereoisomer thereof, or an atropisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a stereoisomer thereof, or a pharmaceutically acceptable salt of an atropisomer thereof;

a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

公开(公告)号：EP3004109A1

公开(公告)日：2016-04-13

申请号：EP14731798.6

申请日：2014-05-26

申请人： Novartis AG

发明人： BLANK, Jutta ,  BOLD, Guido ,  COTESTA, Simona ,  GUAGNANO, Vito ,  RUEEGER, Heinrich ,  VAUPEL, Andrea

IPC分类号： C07D487/04 ,  A61K31/4188 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/4192 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/5025 ,  A61K31/513 ,  A61K31/5377 ,  C07D471/04

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。

公开(公告)号：EP1996558A1

公开(公告)日：2008-12-03

申请号：EP07723223.9

申请日：2007-03-13

申请人： NOVARTIS AG

发明人： BOLD, Guido ,  VAUPEL, Andrea ,  PISSOT SOLDERMANN, Carole ,  MANLEY, Paul, W.

IPC分类号： C07D239/30 ,  C07D239/34 ,  C07D239/36 ,  C07D239/42 ,  C07D239/46 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/06 ,  A61K31/495 ,  A61P35/00

CPC分类号： C07D413/12 ,  C07D239/34 ,  C07D239/36 ,  C07D239/42 ,  C07D239/47 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D417/12 ,  C07D471/06

摘要： The invention relates to novel compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula (I) and to the use of a compound of formula (I) for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.

公开(公告)号：EP2948453B1

公开(公告)日：2017-08-02

申请号：EP14704909.2

申请日：2014-01-21

申请人： Novartis AG

发明人： FURET, Pascal ,  GUAGNANO, Vito ,  HOLZER, Philipp ,  KALLEN, Joerg ,  MAH, Robert ,  MASUYA, Keiichi ,  SCHLAPBACH, Achim ,  VAUPEL, Andrea

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/519

公开(公告)号：EP2948451B1

公开(公告)日：2017-07-12

申请号：EP14703441.7

申请日：2014-01-21

申请人： Novartis AG

发明人： FURET, Pascal ,  GUAGNANO, Vito ,  HOLZER, Philipp ,  KALLEN, Joerg ,  MAH, Robert ,  MASUYA, Keiichi ,  SCHLAPBACH, Achim ,  VAUPEL, Andrea

IPC分类号： C07D473/28 ,  A61K31/522 ,  A61P35/00

CPC分类号： C07D473/28 ,  A61K31/522

公开(公告)号：EP2785717B1

公开(公告)日：2016-01-13

申请号：EP12805775.9

申请日：2012-11-28

申请人： Novartis AG

发明人： FURET, Pascal ,  GUAGNANO, Vito ,  HOLZER, Philipp ,  MAH, Robert ,  MASUYA, Keiichi ,  SCHLAPBACH, Achim ,  STUTZ, Stefan ,  VAUPEL, Andrea

IPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/513 ,  A61K31/506 ,  A61K31/4439 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/41 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377

公开(公告)号：EP2948451A1

公开(公告)日：2015-12-02

申请号：EP14703441.7

申请日：2014-01-21

申请人： Novartis AG

发明人： FURET, Pascal ,  GUAGNANO, Vito ,  HOLZER, Philipp ,  KALLEN, Joerg ,  MAH, Robert ,  MASUYA, Keiichi ,  SCHLAPBACH, Achim ,  VAUPEL, Andrea

IPC分类号： C07D473/28

CPC分类号： C07D473/28 ,  A61K31/522

摘要： The invention relates to compounds of formula (I): (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.

摘要翻译： 本发明涉及如本文所述的式（I）化合物：（I），包含此类化合物的药物制剂，所述化合物用于治疗由MDM2活性介导的病症或疾病的用途和方法，和/或 MDM4以及包含这些化合物的组合。