-
1.发明公开
公开(公告)号：EP4358953A1
公开(公告)日：2024-05-01
申请号：EP22738009.4
申请日：2022-06-23
申请人： Novartis AG
发明人： BRACHMANN, Saskia Maria , COTESTA, Simona , CUI, Xiaoming , DE KANTER, Ruben , FARAGO, Anna , GERSPACHER, Marc , GRAUS PORTA, Diana , KIM, Jaeyeon , LEBLANC, Catherine , LORTHIOIS, Edwige Liliane Jeanne , MACHAUER, Rainer , MAH, Robert , MURA, Christophe , RIGOLLIER, Pascal , PRAHALLAD, Anirudh Cadapa , SCHNEIDER, Nadine , STRINGER, Rowan , STUTZ, Stefan , VAUPEL, Andrea , WARIN, Nicolas , WILCKEN, Rainer , WEISS, Andreas
IPC分类号： A61K31/416 , A61K31/436 , A61K31/4439 , A61K31/4965 , A61K31/497 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K45/06 , A61P35/00 , A61P35/04
CPC分类号： A61K31/416 , A61K31/497 , A61K31/519 , A61K31/4439 , A61K31/436 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/4965 , A61K45/06 , A61P35/00 , A61P35/04
-
公开(公告)号：EP2417108B1
公开(公告)日：2016-08-17
申请号：EP10722776.1
申请日：2010-04-09
申请人： Novartis AG
IPC分类号： C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/14 , A61K31/403 , A61P31/22 , C07K5/08
CPC分类号： C07K7/06 , A61K31/403 , A61K31/4439 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/14 , C07K5/06165 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/10 , C07K5/101 , C07K5/1016
-
公开(公告)号：EP2007789B1
公开(公告)日：2015-05-20
申请号：EP07811837.9
申请日：2007-04-09
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BRANDL, Trixi , FU, Jiping , LENOIR, Francois , PARKER, David Thomas , PATANE, Michael , RADETICH, Branko , RAMAN, Prakash , RIGOLLIER, Pascal , SEEPERSAUD, Mohindra , SIMIC, Oliver , YIFRU, Aregahegn , ZHENG, Rui
IPC分类号： C07K5/078 , C07K5/083 , C07K5/087 , C07K5/103 , C07K5/107 , A61K38/05 , A61P31/14 , C07D401/12 , C07D403/12 , C07D409/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/10 , C07D209/96 , C07K5/065 , C07K5/062
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
-
公开(公告)号：EP2268612A1
公开(公告)日：2011-01-05
申请号：EP09724483.4
申请日：2009-03-23
申请人： Novartis AG
发明人： EHRHARDT, Claus , MCQUIRE, Leslie Wighton , RIGOLLIER, Pascal , ROGEL, Olivier , SHULTZ, Michael , TOMMASI, Ruben Alberto
IPC分类号： C07C311/16 , A61K31/18 , A61P29/00 , C07C317/24 , C07C323/24 , C07D207/20 , C07D209/08 , C07D211/24 , C07D213/40 , C07D235/06 , C07D295/116 , C07D333/18
CPC分类号： C07D333/22 , A61K31/18 , A61K31/381 , A61K31/402 , A61K31/416 , A61K31/437 , A61K31/4402 , A61K31/4409 , A61K31/451 , A61K31/495 , A61K31/5375 , A61K31/55 , A61K45/06 , C07C311/16 , C07C311/29 , C07C311/39 , C07C311/46 , C07C317/24 , C07C323/67 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/20 , C07D207/30 , C07D207/333 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D209/80 , C07D209/82 , C07D211/06 , C07D211/14 , C07D211/24 , C07D213/40 , C07D213/50 , C07D213/61 , C07D221/16 , C07D223/04 , C07D231/56 , C07D235/06 , C07D235/08 , C07D241/04 , C07D265/30 , C07D295/112 , C07D295/116 , C07D295/192 , C07D333/18 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D487/04
摘要： The present invention provides a compound of formula (I): said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition.
-
公开(公告)号：EP4359081A1
公开(公告)日：2024-05-01
申请号：EP22736009.6
申请日：2022-06-22
申请人： Novartis AG
发明人： BOMIO-CONFAGLIA, Claudio , BRACHMANN, Saskia Maria , COTESTA, Simona , GERSPACHER, Marc , LEBLANC, Catherine , LIMA, Fabio , LORTHIOIS, Edwige Liliane Jeanne , MACHAUER, Rainer , MAH, Robert , RACINE, Sophie , RIGOLLIER, Pascal , STUTZ, Stefan , VAUPEL, Andrea , WARIN, Nicolas , WILCKEN, Rainer , ZECRI, Frédéric
IPC分类号： A61P35/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D491/048 , C07D491/056 , C07D491/107 , C07D498/04 , C07D498/08
CPC分类号： C07D401/14 , C07D405/14 , C07D491/048 , C07D417/14 , C07D498/04 , C07D413/14 , C07D491/056 , C07D498/08 , C07D491/107 , A61P35/00
-
公开(公告)号：EP4344702A2
公开(公告)日：2024-04-03
申请号：EP24151713.5
申请日：2020-12-17
申请人： Novartis AG
发明人： COTESTA, Simona , GERSPACHER, Marc , LEBLANC, Catherine , LIU, Bo , LORTHIOIS, Edwige Liliane Jeanne , MACHAUER, Rainer , MAH, Robert , MURA, Christophe , RIGOLLIER, Pascal , SCHNEIDER, Nadine , STUTZ, Stefan , VAUPEL, Andrea , WARIN, Nicolas , WILCKEN, Rainer
IPC分类号： A61K31/425
摘要： The present invention provides a compound of formula (I) or a stereoisomer thereof, or an atropisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a stereoisomer thereof, or a pharmaceutically acceptable salt of an atropisomer thereof;
a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.-
公开(公告)号：EP2125757A1
公开(公告)日：2009-12-02
申请号：EP08707770.7
申请日：2008-02-19
申请人： Novartis AG
发明人： BRITT, Shawn, D. , FU, Jiping , PARKER, David, Thomas , PATANE, Michael A. , RAMAN, Prakash , RADETICH, Branko , SEEPERSAUD, Mohindra , YIFRU, Aregahegn , ZHENG, Rui , BRANDL, Trixi , COTTENS, Sylvain , EHRHARDT, Claus , RANDL, Stefan, Andreas , RIGOLLIER, Pascal , SCHIERING, Nikolaus , SIMIC, Oliver
IPC分类号： C07D257/02 , C07D285/00 , C07D487/04 , C07D487/08 , C07D498/04 , C07D513/04 , C07D515/04 , C07D519/00 , A61K31/395 , A61P31/14 , C07K5/02
CPC分类号： C07D513/04 , C07D257/02 , C07D285/00 , C07D487/04 , C07D487/08 , C07D498/04 , C07D515/04 , C07D519/00 , C07K5/0202 , C07K5/0207 , C07K5/0804 , C07K5/0827 , C07K5/1008 , C07K5/1024
摘要： The present application describes macrocyclic compounds of formula (I) with NS3 protease inhibitory activity for treating hepatitis C virus infection.
-
公开(公告)号：EP2007787A2
公开(公告)日：2008-12-31
申请号：EP07781534.8
申请日：2007-04-09
申请人： NOVARTIS AG , Novartis Pharma GmbH
发明人： BRANDL, Trixi , BRITT, Shawn D. , COTTENS, Sylvain , EHRHARDT, Claus , FU, Jiping , KARUR, Subramanian , LI, Hongju , LU, Peichao , PARKER, David Thomas , PATANE, Michael , RADETICH, Branko , RAMAN, Prakash , RANDL, Stefan Andreas , RIGOLLIER, Pascal , SEEPERSAUD, Mohindra , SIMIC, Oliver , TICHKULE, Ritesh Bhanudasji , ZHU, Yanyi
CPC分类号： C07K5/1016 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C12N2770/24211
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
-
公开(公告)号：EP4344702A3
公开(公告)日：2024-04-10
申请号：EP24151713.5
申请日：2020-12-17
申请人： Novartis AG
发明人： COTESTA, Simona , GERSPACHER, Marc , LEBLANC, Catherine , LIU, Bo , LORTHIOIS, Edwige Liliane Jeanne , MACHAUER, Rainer , MAH, Robert , MURA, Christophe , RIGOLLIER, Pascal , SCHNEIDER, Nadine , STUTZ, Stefan , VAUPEL, Andrea , WARIN, Nicolas , WILCKEN, Rainer
IPC分类号： A61P35/00 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/416
摘要： The present invention provides a compound of formula (I) or a stereoisomer thereof, or an atropisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a stereoisomer thereof, or a pharmaceutically acceptable salt of an atropisomer thereof;
a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.-
10.发明授权ARYLSULFONAMIDE-BASED MATRIX METALLOPROTEASE INHIBITORS 有权MATRIX-METALLOPROTEINASEINHIBITOREN AUF ARYLSULFONAMIDBASIS
公开(公告)号：EP2268612B1
公开(公告)日：2014-08-20
申请号：EP09724483.4
申请日：2009-03-23
申请人： Novartis AG
发明人： EHRHARDT, Claus , MCQUIRE, Leslie Wighton , RIGOLLIER, Pascal , ROGEL, Olivier , SHULTZ, Michael , TOMMASI, Ruben Alberto
IPC分类号： C07C311/16 , A61K31/18 , A61P29/00 , C07C317/24 , C07C323/24 , C07D207/20 , C07D209/08 , C07D211/24 , C07D213/40 , C07D235/06 , C07D295/116 , C07D333/18
CPC分类号： C07D333/22 , A61K31/18 , A61K31/381 , A61K31/402 , A61K31/416 , A61K31/437 , A61K31/4402 , A61K31/4409 , A61K31/451 , A61K31/495 , A61K31/5375 , A61K31/55 , A61K45/06 , C07C311/16 , C07C311/29 , C07C311/39 , C07C311/46 , C07C317/24 , C07C323/67 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/20 , C07D207/30 , C07D207/333 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D209/80 , C07D209/82 , C07D211/06 , C07D211/14 , C07D211/24 , C07D213/40 , C07D213/50 , C07D213/61 , C07D221/16 , C07D223/04 , C07D231/56 , C07D235/06 , C07D235/08 , C07D241/04 , C07D265/30 , C07D295/112 , C07D295/116 , C07D295/192 , C07D333/18 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D487/04
摘要： The present invention provides a compound of formula (I): said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译： 本发明提供式（I）化合物：所述化合物是MMP-2和/或MMP-8和/或MMP-9和/或MMP-12和/或MMP-13的抑制剂，因此 可用于治疗以MMP-2，/或MMP-8和/或MMP-9，和/或MMP-12和/或MMP-13异常活性为特征的病症或疾病。 因此，式（I）化合物可用于治疗由MMP-2和/或MMP-8和/或MMP-9和/或MMP-12和/或MMP- 13。 最后，本发明还提供药物组合物。
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.021 秒)
