公开(公告)号：EP1551827A1

公开(公告)日：2005-07-13

申请号：EP03798931.6

申请日：2003-10-06

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： ALBERT, Rainer ,  COOKE, Nigel, Graham ,  THOMA, Gebhard ,  STREIFF, Markus

IPC分类号： C07D401/14 ,  C07D211/58 ,  A61K31/4545

CPC分类号： C07D401/14 ,  C07D211/58 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

摘要： Disclosed are compounds of formula (I) wherein R1, R2, R3 and X are as defined herein, in free or salt form, which are useful as CCR5 inhibitors, e.g. in the prevention or treatment of disorders mediated by interactions between chemokine receptors and their ligands.

公开(公告)号：EP1337527A1

公开(公告)日：2003-08-27

申请号：EP01993604.6

申请日：2001-11-05

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： ALBERT, Rainer ,  COOKE, Nigel, Graham ,  COTTENS, Sylvain ,  EHRHARDT, Claus ,  EVENOU, Jean-Pierre ,  SEDRANI, Richard ,  VON MATT, Peter ,  WAGNER, Jürgen ,  ZENKE, Gerhard

IPC分类号： C07D403/04 ,  C07D403/14 ,  A61K31/404 ,  A61P29/00 ,  A61P37/06

CPC分类号： C07D403/14 ,  A61K45/06 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/14 ,  C07D403/04 ,  C07D471/10

摘要： Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.

公开(公告)号：EP1307486A2

公开(公告)日：2003-05-07

申请号：EP01969555.0

申请日：2001-07-30

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： ALBERT, Rainer ,  BAUER, Wilfried ,  BODMER, David ,  BRUNS, Christian ,  FELNER, Ivo ,  HELLSTERN, Heribert ,  LEWIS, Ian ,  MEISENBACH, Mark ,  WECKBECKER, Gisbert ,  WIETFELD, Bernhard

IPC分类号： C07K14/655 ,  G01N33/74 ,  A61K51/08

CPC分类号： C07K7/64 ,  A61K38/00 ,  C07K14/655 ,  Y02P20/55

摘要： The invention provides cyclo[{4-(NH2-C2H4-NH-CO-O-)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.

公开(公告)号：EP1660449B1

公开(公告)日：2009-11-18

申请号：EP04764563.5

申请日：2004-08-27

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： ALBERT, Rainer ,  FRANCOTTE, Eric ,  ZECRI, Frédéric ,  ZOLLINGER, Markus

IPC分类号： C07D209/46 ,  C07F9/09 ,  A61K31/137 ,  A61K31/661 ,  A61P37/02

CPC分类号： C07F9/5728 ,  C07D209/46 ,  C07D263/14 ,  C07F9/094 ,  C07F9/653 ,  Y10T436/163333

摘要： Compounds of formula (I): wherein R1, R2, n and m are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.

公开(公告)号：EP1220852B1

公开(公告)日：2006-01-18

申请号：EP00969490.2

申请日：2000-10-11

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： ALBERT, Rainer ,  EHRHARDT, Claus ,  HOMMEL, Ulrich ,  KALLEN, Jörg ,  MEINGASSNER, Josef, Gottfried ,  ROCHE, Didier ,  WATTANASIN, Sompong ,  WEITZ-SCHMIDT, Gabriele ,  WELZENBACH, Karl

IPC分类号： C07D401/06 ,  C07D243/08 ,  A61K31/4709 ,  A61K31/551

CPC分类号： C07K5/06139 ,  A61K38/05 ,  A61K31/00 ,  A61K2300/00

摘要： The invention provides novel diazepanes having interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1, -ICAM-2 or -ICAM-3 interactions.

公开(公告)号：EP1377593A2

公开(公告)日：2004-01-07

申请号：EP02727484.4

申请日：2002-03-26

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： ALBERT, Rainer ,  BAUMRUKER, Thomas ,  BRINKMANN, Volker ,  COTTENS, Sylvain ,  PAPAGEORGIOU, Christos ,  PRIESCHL-STRASSMAYR, Eva, Erika ,  HINTERDING, Klaus

IPC分类号： C07F9/09 ,  A61K31/661 ,  A61K31/137 ,  A61P31/00 ,  A61P17/00 ,  C07C225/16 ,  C07C271/16 ,  C07C217/64 ,  A61P19/00

CPC分类号： C07F9/65744 ,  C07B2200/07 ,  C07C217/64 ,  C07C225/16 ,  C07C271/16 ,  C07C2601/14 ,  C07F9/094 ,  C07F9/113 ,  C07F9/12

摘要： Compounds of formula (I), wherein m, R, R1 and R3 to R6 are as defined in the specification, m, is 1, 2 or 3 and X is O or a direct bond, and the corresponding unphosporylated compounds have interesting properties, e.g. immunosuppressive properties.