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公开(公告)号：EP3586869A1
公开(公告)日：2020-01-01
申请号：EP18757920.6
申请日：2018-02-20
Applicant: Osaka University , Funpep Co., Ltd.
Inventor： SHIMAMURA, Munehisa , KAWANO, Tomohiro , NAKAGAMI, Hironori , MORISHITA, Ryuichi , MOCHIZUKI, Hideki , TENMA, Akiko , EHARA, Takako
Abstract: Provided is an immunogenic composition comprising an antigenic peptide capable of inducing production of a neutralizing antibody against S100A9 and a carrier protein. The immunogenic composition can be used as a highly safe antithrombotic vaccine having antithrombotic effect without a long-term bleeding risk and is useful for the prevention of a disease associated with thrombus formation in which platelet aggregation is involved, particularly for the prevention of recurrent ischemic stroke.
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公开(公告)号：EP3434279A1
公开(公告)日：2019-01-30
申请号：EP17770449.1
申请日：2017-03-24
Applicant: Osaka University , Funpep Co., Ltd.
Inventor： NAKAGAMI, Hironori , MORISHITA, Ryuichi , TENMA, Akiko
Abstract: The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.
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公开(公告)号：EP2698164B1
公开(公告)日：2018-04-04
申请号：EP12771621.5
申请日：2012-04-13
Applicant: Osaka University , AnGes, Inc.
Inventor： MORISHITA, Ryuichi , NAKAGAMI, Hironori , KORIYAMA, Hiroshi , NAKAGAMI, Futoshi , YOSHIDA, Natsuki
IPC: A61K39/00 , A61K35/76 , A61K39/29 , A61K48/00 , A61P3/06 , A61P9/12 , C07K14/02 , C07K14/47 , C12N15/09 , A61K39/12 , C07K14/575
CPC classification number: A61K39/292 , A61K39/0005 , A61K2039/53 , C07K14/575 , C07K2319/00 , C12N2730/10143 , C12N2770/32434
Abstract: The present invention provides a therapeutic or improving agent for a lifestyle-related disease, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of the lifestyle-related disease-related factor, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.
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公开(公告)号：EP3088000A1
公开(公告)日：2016-11-02
申请号：EP14873679.6
申请日：2014-12-26
Applicant: Osaka University
Inventor： KORIYAMA, Hiroshi , NAKAGAMI, Hironori , MORISHITA, Ryuichi
IPC: A61K39/00 , A61K39/395 , A61K48/00 , A61P1/04 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/08 , C07K16/24
CPC classification number: C07K16/244 , A61K39/0005 , C07K2317/34 , C07K2317/76
Abstract: The present invention provides a vaccine against IL-17A, which uses, as an immunogen, a polypeptide containing the amino acid sequence shown in SEQ ID NO: 1, or an amino acid sequence derived from a non-human mammal, which corresponds to SEQ ID NO: 1, a prophylactic or therapeutic agent containing the vaccine for diseases involving IL-17A as an aggravation factor, and the like.
Abstract translation: 本发明提供了一种针对IL-17A的疫苗，其使用包含SEQ ID NO：1所示的氨基酸序列的多肽或来自非人哺乳动物的氨基酸序列作为免疫原，其对应于SEQ ID NO： ID NO：1，含有涉及IL-17A的疾病疫苗作为加重因子的预防或治疗剂等。
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公开(公告)号：EP2698164A1
公开(公告)日：2014-02-19
申请号：EP12771621.5
申请日：2012-04-13
Applicant: Osaka University , AnGes MG, Inc.
Inventor： MORISHITA, Ryuichi , NAKAGAMI, Hironori , KORIYAMA, Hiroshi , NAKAGAMI, Futoshi , YOSHIDA, Natsuki
IPC: A61K39/00 , A61K35/76 , A61K39/29 , A61K48/00 , A61P3/06 , A61P9/12 , C07K14/02 , C07K14/47 , C12N15/09
CPC classification number: A61K39/292 , A61K39/0005 , A61K2039/53 , C07K14/575 , C07K2319/00 , C12N2730/10143 , C12N2770/32434
Abstract: The present invention provides a therapeutic or improving agent for a lifestyle-related disease, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of the lifestyle-related disease-related factor, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.
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Patent Agency Ranking
公开(公告)号：EP4445910A1
公开(公告)日：2024-10-16
申请号：EP22904247.8
申请日：2022-12-07
Applicant: OSAKA UNIVERSITY , Funpep Co., Ltd.
Inventor： NAKAGAMI, Hironori , HAYASHI, Hiroki , MORISHITA, Ryuichi , SAKAGUCHI, Makoto , KAWABATA, Sotaro
IPC: A61K39/00 , A61K47/55 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00
Abstract: The present invention provides a vaccine composition containing a complex of a T cell receptor antigen peptide and a B cell receptor antigen peptide and capable of inducing the production of an antibody against IL-23, wherein the B cell receptor antigen peptide is represented by the following formula (I):
X1-X2-X3-X4-X5-X6-X7-X8 (I)
wherein
X1 is S, A, G, T, K, or R,
X2 is P, A, G, S, T, K, or R,
X3 is S, A, G, T, K, or R,
X4 is Q, A, G, T, or N,
X5 is P, A, G, S, T, Q, or N,
X6 is W, A, Y, or F,
X7 is Q, A, G, T, or N, and
X8 is R, A, G, or K.-
公开(公告)号：EP4223305A1
公开(公告)日：2023-08-09
申请号：EP21875522.1
申请日：2021-09-27
Applicant: OSAKA UNIVERSITY
Inventor： SHIMAMURA, Munehisa , NAKAGAMI, Hironori , MORISHITA, Ryuichi
Abstract: Provided are preventive or therapeutic agents for fibrotic diseases and cancer. A Wnt signaling pathway inhibitor or a preventive and therapeutic agent for fibrotic diseases or cancer, both comprising an oligopeptide consisting of an amino acid sequence containing a DE loop sequence of RANKL protein and a β-strand D sequence of RANKL protein placed adjacent to the N-terminal side of the DE loop sequence.
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公开(公告)号：EP2966087B1
公开(公告)日：2020-05-06
申请号：EP14761201.4
申请日：2014-03-06
Applicant: Osaka University
Inventor： TANIYAMA, Yoshiaki , MORISHITA, Ryuichi , AZUMA, Junya , SANADA, Fumihiro , KATSURAGI, Naruto
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19.发明授权CANCER REMEDY CONTAINING ANTIBODY AGAINST PEPTIDE ENCODED BY EXON-17 OF PERIOSTIN 有权用单克隆抗体抗外显子-17区域的骨膜CODED肽的治愈癌症
公开(公告)号：EP2168599B1
公开(公告)日：2016-08-10
申请号：EP08777680.3
申请日：2008-06-27
Applicant: Osaka University
Inventor： TANIYAMA, Yoshiaki , MORISHITA, Ryuichi , KATSURAGI, Naruto
IPC: A61K39/395 , A61P35/00 , A61P35/04 , G01N33/574
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/30 , C07K2317/34 , C07K2317/73 , G01N33/57484
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20.发明公开ANTIBODY TO PEPTIDE ENCODED BY EXON-21 OF PERIOSTIN, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF INFLAMMATORY DISEASE CONTAINING SAID ANTIBODY 审中-公开抗体由外显子21这种抗体的预防和炎症疾病的治疗骨膜编码肽和药物组合物。
公开(公告)号：EP2966087A1
公开(公告)日：2016-01-13
申请号：EP14761201.4
申请日：2014-03-06
Applicant: Osaka University
Inventor： TANIYAMA, Yoshiaki , MORISHITA, Ryuichi , AZUMA, Junya , SANADA, Fumihiro , KATSURAGI, Naruto
IPC: C07K16/18 , A61K39/395 , A61P9/08 , A61P29/00 , A61P35/00 , C07K16/46 , C12N5/10 , C12P21/08 , G01N33/53 , C12N15/02
Abstract: The present invention provides a drug for preventing or treating inflammation-associated diseases in which a periostin isoform having cell adhesion activity is involved, and also provides an inhibitor of a periostin isoform having cell adhesion activity.
Abstract translation: 本发明提供的药物用于预防或治疗炎症相关的疾病，其中的骨膜具有同种型的细胞粘附活性参与，等等提供抑制剂具有细胞粘附活性的骨膜素的。
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