-
公开(公告)号：EP4446343A1
公开(公告)日：2024-10-16
申请号：EP22904212.2
申请日：2022-12-06
Applicant: OSAKA UNIVERSITY , Periotherapia Co., Ltd.
Inventor： TANIYAMA, Yoshiaki , SANADA, Fumihiro , MORISHITA, Ryuichi
IPC: C07K16/28 , A61K39/395 , A61P9/14 , A61P29/00 , A61P35/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/13
Abstract: An object is to provide a novel antibody or antigen-binding fragment thereof against exon 21 of human periostin. The object is achieved by an antibody or antigen-binding fragment thereof bindable to a conformational epitope on human periostin, wherein the epitope contains the amino acid sequence A represented by SEQ ID NO: 61 and the amino acid sequence B represented by any one of SEQ ID NOs: 62 to 64.
-
公开(公告)号：EP4129200A1
公开(公告)日：2023-02-08
申请号：EP21774074.5
申请日：2021-02-12
Applicant: OSAKA UNIVERSITY
Inventor： TAKEDA, Shuko , MORISHITA, Ryuichi
Abstract: A cognitive impairment diagnostic device (1) includes: an obtainer (41) that obtains a distribution map representing a distribution of gaze points of a subject on a movie for cognitive assessment; and a diagnoser (39). The movie for cognitive assessment includes, in time order: a first movie including a first region including an image for encoding displayed in a visually enhanced manner, and a plurality of second regions including normal images displayed without being enhanced; and an assessment movie including a third region including an assessment image similar to the image for encoding and displayed at a same position as the image for encoding without being visually enhanced, and the second regions. The diagnoser (39) calculates, in a distribution map on the assessment movie, a percentage of fixation duration for which the third region is focused on, and makes diagnosis of suspected memory impairment when the percentage of fixation duration is lower than a threshold.
-
公开(公告)号：EP3744333A1
公开(公告)日：2020-12-02
申请号：EP19743472.3
申请日：2019-01-23
Applicant: Osaka University
Inventor： SANADA, Fumihiro , TANIYAMA, Yoshiaki , MORISHITA, Ryuichi
IPC: A61K31/711 , A61K35/76 , A61K48/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/08 , A61P43/00
Abstract: Provided is a pharmaceutical composition for the treatment of a disease associated with upregulated periostin expression or periostin splice variant switching, which pharmaceutical composition comprises, as an active ingredient, a nucleic acid capable of inducing skipping of exon 17 in periostin gene transcription and/or a nucleic acid capable of inducing skipping of exon 21 in periostin gene transcription. The pharmaceutical composition of the present invention can treat a disease associated with upregulated periostin expression or periostin splice variant switching, while preventing complete inhibition of the functions of periostin.
-
公开(公告)号：EP3000824B1
公开(公告)日：2020-09-02
申请号：EP14773035.2
申请日：2014-03-27
Applicant: Osaka University
Inventor： NAKAGAMI, Hironori , MORISHITA, Ryuichi , TOMIOKA, Hideki , TENMA, Akiko
-
公开(公告)号：EP3199543B1
公开(公告)日：2020-08-26
申请号：EP15844602.1
申请日：2015-09-25
Applicant: Osaka University
Inventor： NAKAGAMI, Hironori , MORISHITA, Ryuichi , KORIYAMA, Hiroshi , TENMA, Akiko
-
Patent Agency Ranking6.发明公开
公开(公告)号：EP3299382A1
公开(公告)日：2018-03-28
申请号：EP16796464.2
申请日：2016-05-16
Applicant: Osaka University
Inventor： SHIMAMURA, Munehisa , NAKAGAMI, Hironori , KURINAMI, Hitomi , MORISHITA, Ryuichi
IPC: C07K7/06 , A61K38/00 , A61P7/02 , A61P9/10 , A61P19/10 , A61P31/04 , A61P35/00 , A61P35/04 , A61P43/00
CPC classification number: A61K38/1709 , A61K38/00 , A61K38/19 , A61P19/10 , A61P29/00 , A61P35/00 , C07K7/06 , C07K14/4703 , C07K14/52
Abstract: Provided is an oligopeptide having preventive and therapeutic effects on infarction diseases. The oligopeptide contains a DE loop sequence of RANKL protein, and has inhibitory activity on proinflammatory cytokine secretion from cells.
Abstract translation: 提供了对梗塞疾病具有预防和治疗作用的寡肽。 寡肽含有RANKL蛋白的DE环序列，并且具有抑制从细胞分泌促炎细胞因子的活性。
-
7.发明公开DPP-4-TARGETING VACCINE FOR TREATING DIABETES 审中-公开DPP-4-ANZIELENDER IMPFSTOFF ZUR BEHANDLUNG VON糖尿病
公开(公告)号：EP3042667A1
公开(公告)日：2016-07-13
申请号：EP14842753.7
申请日：2014-08-27
Applicant: Osaka University
Inventor： NAKAGAMI, Hironori , MORISHITA, Ryuichi , KORIYAMA, Hiroshi
IPC: A61K39/00 , A61K39/395 , A61P3/10 , C12N15/09
CPC classification number: A61K39/0005 , A61K2039/55594 , A61K2039/58 , C07K16/2896 , C07K16/40 , C07K2317/76 , C07K2317/94 , C12N9/6421
Abstract: The present invention provides a vaccine for the prophylaxis or treatment of diabetes using a polypeptide containing the amino acid sequence shown by SEQ ID NO: 2 or an amino acid sequence of a non-human mammal, which corresponds to SEQ ID NO: 2, and the like as an immunogen, which induces a neutralizing antibody to DPP-4, and a prophylactic or therapeutic agent for diabetes, which contains a DDP-4 neutralizing antibody that recognizes a partial amino acid sequence of the aforementioned DDP-4.
Abstract translation: 本发明提供了使用含有SEQ ID NO：2所示的氨基酸序列的多肽或非人哺乳动物的氨基酸序列（其对应于SEQ ID NO：2）预防或治疗糖尿病的疫苗，以及 作为免疫原的类似物，其诱导DPP-4的中和抗体，以及含有识别上述DDP-4的部分氨基酸序列的DDP-4中和抗体的糖尿病预防或治疗剂。
-
8.发明公开DNA VACCINE CONTAINING VEGF-SPECIFIC EPITOPE AND/OR ANGIOPOIETIN-2-SPECIFIC EPITOPE 审中-公开DNA-IMPFSTOFFHALTIGES VEGF-SPEZIFISCHES EPITOP UND / ODER ANGIOPOIETIN-2-SPEZIFISCHES EPITOP
公开(公告)号：EP2891497A1
公开(公告)日：2015-07-08
申请号：EP13832772.1
申请日：2013-08-28
Applicant: Osaka University , AnGes MG, Inc.
Inventor： NAKAGAMI, Hironori , KYUTOKU, Mariko , MORISHITA, Ryuichi , TOMIOKA, Hideki
CPC classification number: A61K39/0011 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C12N7/00 , C12N2730/10134 , C12N2730/10143
Abstract: The present invention provides a therapeutic or prophylactic agent for cancer, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of VEGF and/or a specific epitope of angiopoietin-2, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.
Abstract translation: 本发明提供了一种癌症治疗剂或预防剂，其含有编码嵌合乙型肝炎病毒核心抗原多肽的表达载体，其插入含有VEGF特异性表位的氨基酸序列和/或血管生成素-2的特异性表位，其中， 将包含特异性表位的氨基酸序列插入到乙型肝炎病毒核心抗原多肽的氨基酸残基80和81之间。
-
公开(公告)号：EP4194007A1
公开(公告)日：2023-06-14
申请号：EP22204662.5
申请日：2017-03-24
Applicant: OSAKA UNIVERSITY , Funpep Co., Ltd.
Inventor： NAKAGAMI, Hironori , MORISHITA, Ryuichi , TENMA, Akiko
Abstract: The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.
-
10.发明公开
公开(公告)号：EP3711680A1
公开(公告)日：2020-09-23
申请号：EP18878289.0
申请日：2018-11-13
Applicant: Osaka University
Inventor： TAKEDA, Shuko , MORISHITA, Ryuichi , OYAMA, Akane , NAKAJIMA, Tsuneo
Abstract: A cognitive impairment diagnostic apparatus (1) includes: a display (10) which displays a video for diagnosis of cognitive impairment on a display surface (11); an imaging unit (21) which captures images of an eye of a subject; a detection unit (37) which detects viewpoints of the subject on the display surface (11) in time series based on the images captured by the imaging unit (21); a creation unit (38) which creates a distribution map representing a distribution of the viewpoints detected by the detection unit (37); a storage unit (32) which stores case characteristic data (310) indicating a characteristic of a viewpoint distribution corresponding to a typical case in cognitive impairment; and a diagnostic unit (39) which diagnoses cognitive impairment of the subject by determining whether the distribution map has the characteristic indicated by the case characteristic data.
-
-
-
-
-
-
-
-
-
Search Results
33
records
(took 0.021 seconds)
