公开(公告)号：EP2321264A2

公开(公告)日：2011-05-18

申请号：EP09800666.1

申请日：2009-07-22

申请人： President and Fellows of Harvard College ,  Dana-Farber Cancer Institute Inc.

发明人： TANG, Weiping ,  BRADNER, James, Elliot ,  SCHREIBER, Stuart, L.

IPC分类号： C07C251/86 ,  A61K31/15 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07C259/06 ,  C07C251/86

摘要： The present invention provides novel compounds of formula (I) and pharmaceutical compositions thereof. The inventive compounds are useful as deacetylase inhibitors (e.g., histone deacetylase inhibitors) and may be useful in the treatment of proliferative diseases such as cancer. In particular, the inventive compounds are HDAC6 inhibitors. The invention also provide synthetic methods for preparing the inventive compounds.

摘要翻译： 本发明提供了新的式（I）化合物及其药物组合物。 本发明的化合物可用作脱乙酰酶抑制剂（例如组蛋白脱乙酰酶抑制剂）并可用于治疗增殖性疾病如癌症。 特别地，本发明的化合物是HDAC6抑制剂。 本发明还提供了用于制备本发明化合物的合成方法。

公开(公告)号：EP1991247A1

公开(公告)日：2008-11-19

申请号：EP07872648.6

申请日：2007-02-14

申请人： The President and Fellows of Harvard College ,  Dana-Farber Cancer Institute

发明人： BRADNER, James, Elliot ,  MAZITSCHEK, Ralph ,  TANG, Weiping ,  SCHREIBER, Stuart, L.

IPC分类号： A61K38/00 ,  A61K31/44 ,  A61K31/19

CPC分类号： A61K31/19 ,  A61K31/44 ,  A61K47/55 ,  C07C259/06 ,  C07D249/04 ,  C07D249/06 ,  C07D413/12

摘要： In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.

公开(公告)号：EP1053241A1

公开(公告)日：2000-11-22

申请号：EP99906981.8

申请日：1999-02-12

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： SCHREIBER, Stuart, L. ,  CRABTREE, Gerald, R. ,  LIBERLES, Stephen, D.

IPC分类号： C07D498/18 ,  C07K1/107 ,  C07K1/14 ,  C12N15/56

CPC分类号： C07D498/18 ,  C07K1/1075 ,  C07K1/1077

摘要： Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells.