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11.发明公开COMPOSITIONS AND METHODS FOR THE GENERATION OF PROTECTIVE IMMUNE RESPONSE AGAINST MALARIA 有权方法和组合物形成保护性免疫反应恶性疟原虫
公开(公告)号：EP1599225A2
公开(公告)日：2005-11-30
申请号：EP04716571.7
申请日：2004-03-03
发明人： PLUSCHKE, Gerd , MÜLLER, Markus , ROBINSON, John , ZURBRIGGEN, Rinaldo , FREUND-RENARD, Annabelle
IPC分类号： A61K39/015 , A61P33/06
CPC分类号： A61K39/015 , A61K2039/55555 , A61K2039/6018 , Y02A50/412
摘要： The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory antibodies. The cyclized or linear peptides can be applied by known adjuvants or be encapsulated by or attached onto the surface of liposomes or virosomes (IRIVs) which serve as human compatible antigen delivery systems. Both cyclized and linear versions of the peptide antigens are surprisingly effective in eliciting immune responses that are cross-reactive with parasite-expressed AMA-1.
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公开(公告)号：EP2201109A1
公开(公告)日：2010-06-30
申请号：EP08802426.0
申请日：2008-09-19
CPC分类号： A61K39/0002 , A61K38/00 , C12N9/6478 , C12Q1/68 , G01N33/573 , Y02A50/471 , Y02A50/473
摘要： The present invention relates to a truncated form of the secretory aspartyl proteinase 2 (Sap2), as well as to nucleic acid molecules encoding same. This truncated Sap2 polypeptide (tSap2) is surprisingly stable and devoid of enzymatic activity but retains full immunogenicity upon intravaginal administration and confers full protection against intravaginal challenge by the Candida fungus. The present invention further relates to compositions comprising tSap2 and to the use of tSap2 in the preparation of such compositions.
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公开(公告)号：EP1973566A1
公开(公告)日：2008-10-01
申请号：EP06841001.8
申请日：2006-12-15
申请人： Pevion Biotech Ltd.
IPC分类号： A61K39/145
CPC分类号： A61K39/39 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/55555 , C12N7/00 , C12N2760/16123 , C12N2760/16134
摘要： The invention relates to novel adjuvant systems that generate efficient immune responses against antigens of choice. The novel adjuvant systems of the present invention are based on virosomes. Thus the invention is directed to pharmaceutical compositions comprising virosomes, at least one antigenic molecule, and a carrier vehicle, methods for preparing such compositions and uses thereof.
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公开(公告)号：EP1833465A2
公开(公告)日：2007-09-19
申请号：EP05824123.3
申请日：2005-12-21
申请人： Pevion Biotech Ltd.
CPC分类号： A61K47/28 , A61K9/1272 , A61K9/19 , A61K31/704 , A61K39/015 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/55555 , A61K2039/70 , C12N2760/16134 , C12N2760/16142 , C12N2760/16234
摘要： The present invention relates to compositions and methods for the effective lyophilization and reconstitution of virosomes.
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15.发明公开IMMUNOGENIC COMPOSITIONS OF CYCLIC PEPTIDES DERIVED FROM THE BETA-AMYLOID PEPTIDE 审中-公开免疫原性组合物的环肽ABGEGLEITETβ-淀粉样肽的
公开(公告)号：EP1831251A1
公开(公告)日：2007-09-12
申请号：EP05821738.1
申请日：2005-12-21
申请人： Pevion Biotech Ltd.
发明人： ZURBRIGGEN, Rinaldo
CPC分类号： C07K14/4711
摘要： The present invention relates to methods and compositions for the elicitation of an immune response against amyloid beta-peptides, in particular by the combinatory use of virosomes as adjuvants and a synthetic amyloid beta-peptide antigen.
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16.发明授权COMPOSITIONS AND METHODS FOR THE GENERATION OF PROTECTIVE IMMUNE RESPONSE AGAINST MALARIA 有权方法和组合物形成保护性免疫反应恶性疟原虫
公开(公告)号：EP1599225B1
公开(公告)日：2007-05-16
申请号：EP04716571.7
申请日：2004-03-03
发明人： PLUSCHKE, Gerd , MÜLLER, Markus , ROBINSON, John , ZURBRIGGEN, Rinaldo , FREUND-RENARD, Annabelle
IPC分类号： A61K39/015 , A61P33/06
CPC分类号： A61K39/015 , A61K2039/55555 , A61K2039/6018 , Y02A50/412
摘要： The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory antibodies. The cyclized or linear peptides can be applied by known adjuvants or be encapsulated by or attached onto the surface of liposomes or virosomes (IRIVs) which serve as human compatible antigen delivery systems. Both cyclized and linear versions of the peptide antigens are surprisingly effective in eliciting immune responses that are cross-reactive with parasite-expressed AMA-1.
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17.发明公开METHODS FOR SYNTHESIZING CONFORMATIONALLY CONSTRAINED PEPTIDES, PEPTIDOMETICS AND THE USE THEREOF AS SYNTHETIC VACCINES 有权合成方法阻碍构象肽PEPTIDOMETIKA及其作为合成疫苗
公开(公告)号：EP1629002A1
公开(公告)日：2006-03-01
申请号：EP04739532.2
申请日：2004-06-02
IPC分类号： C07K7/56 , C07K1/04 , C07K16/20 , A61K38/12 , A61K39/015
CPC分类号： G01N33/56911 , A61K38/00 , A61K39/00 , A61K39/015 , C07K7/56 , C07K16/205 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S,4S)-4-functionalized proline residue. The invention further relates to the use of (2S,4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.
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