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公开(公告)号:EP3544972A1
公开(公告)日:2019-10-02
申请号:EP17818281.2
申请日:2017-11-27
申请人: Pfizer Inc.
发明人: ARORA, Kapildev Kashmirilal , BRODNEY, Michael Aaron , DUNN, Matthew Francis , GREEN, Michael Eric , KABLAOUI, Natasha Mariam , KAUFFMAN, Gregory Wayne , MENTE, Scot Richard , MONTGOMERY, Justin Ian , RANKIC, Danica Antonia , ROGERS, Bruce Nelsen , VERHOEST, Patrick Robert
IPC分类号: C07D403/04 , C07D413/04 , C07D417/04 , A61K31/4155 , A61K31/433 , A61K31/5375 , A61P25/00
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公开(公告)号:EP3052495B1
公开(公告)日:2019-06-26
申请号:EP14793620.7
申请日:2014-09-22
申请人: Pfizer Inc.
发明人: PETTERSSON, Martin Youngjin , JOHNSON, Douglas Scott , SUBRAMANYAM, Chakrapani , O'DONNELL, Christopher John , AM ENDE, Christopher William , GREEN, Michael Eric , PATEL, Nandini Chaturbhai , STIFF, Cory Michael , TRAN, Tuan Phong , KAUFFMAN, Gregory Wayne , STEPAN, Antonia Friederike , VERHOEST, Patrick Robert
IPC分类号: C07D471/04 , C07D498/04 , A61K31/498 , A61P25/00
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公开(公告)号:EP3013813B1
公开(公告)日:2019-04-03
申请号:EP14739554.5
申请日:2014-06-13
申请人: Pfizer Inc.
发明人: BRODNEY, Michael Aaron , DAVOREN, Jennifer Elizabeth , DOUNAY, Amy Beth , EFREMOV, Ivan Viktorovich , GRAY, David Lawrence Firman , GREEN, Michael Eric , HENDERSON, Jaclyn Louise , LEE, Chewah , MENTE, Scot Richard , O'NEIL, Steven Victor , ROGERS, Bruce Nelsen , ZHANG, Lei
IPC分类号: C07D401/14 , C07D405/14 , C07D401/12 , A61K31/513 , A61K31/501 , A61K31/497 , A61P25/00
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公开(公告)号:EP2917195B9
公开(公告)日:2018-05-30
申请号:EP13821520.7
申请日:2013-10-22
申请人: Pfizer Inc.
发明人: DIRICO, Kenneth John , EUSTAQUIO, Alessandra S. , GREEN, Michael Eric , HE, Haiyin , HE, Min , KOEHN, Frank Erich , O'DONNELL, Christopher John , PUTHENVEETIL, Sujiet , RATNAYAKE, Anokha Sayani , SUBRAMANYAM, Chakrapani , TESKE, Jesse Alexander , YANG, Hui Yu
IPC分类号: C07D309/10 , C07D405/12 , C07D493/20 , A61K31/35 , A61P35/00
CPC分类号: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
摘要: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
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公开(公告)号:EP2691393B1
公开(公告)日:2016-09-14
申请号:EP12713360.1
申请日:2012-03-21
申请人: Pfizer Inc.
发明人: AM ENDE, Christopher William , FISH, Benjamin Adam , GREEN, Michael Eric , JOHNSON, Douglas Scott , MULLINS, Patrick Bradley , O'DONNELL, Christopher John , PETTERSSON, Martin Youngjin , STIFF, Cory Michael , SUBRAMANYAM, Chakrapani , TRAN, Tuan Phong , NAVARATNAM, Thayalan
IPC分类号: C07D471/04 , A61K31/4985 , A61P25/00
CPC分类号: C07D471/04 , A61K31/4985 , A61K31/695 , A61K45/06 , C07D401/04 , C07D491/048 , C07F7/0812
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公开(公告)号:EP2917195A1
公开(公告)日:2015-09-16
申请号:EP13821520.7
申请日:2013-10-22
申请人: Pfizer Inc.
发明人: DIRICO, Kenneth John , EUSTAQUIO, Alessandra S. , GREEN, Michael Eric , HE, Haiyin , HE, Min , KOEHN, Frank Erich , O'DONNELL, Christopher John , PUTHENVEETIL, Sujiet , RATNAYAKE, Anokha Sayani , SUBRAMANYAM, Chakrapani , TESKE, Jesse Alexander , YANG, Hui Yu
IPC分类号: C07D309/10 , C07D405/12 , C07D493/20
CPC分类号: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
摘要: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
摘要翻译: 本发明涉及新的细胞毒性剪接抑制素类似物(I)及其衍生物,涉及其抗体药物缀合物,以及使用其来治疗包括癌症的医学病症的方法。
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