Method for biotechnologically preparing (S)-(-)-alpha-cyano-3-phenoxybenzyl alcohol
    12.
    发明公开
    Method for biotechnologically preparing (S)-(-)-alpha-cyano-3-phenoxybenzyl alcohol 失效
    生物技术制备(S) - ( - ) - 阿尔法 - 氰基-3-苯甲酰基醇的方法

    公开(公告)号:EP0080827A3

    公开(公告)日:1984-05-23

    申请号:EP82306125

    申请日:1982-11-17

    IPC分类号: C12P13/00 A01N37/38 C12N09/18

    CPC分类号: C12P13/004

    摘要: (S)-(-)-α-cyano-3-phenoxybenzyl alcohol, which is the alcohol moiety of pyrethroids, effective insecticides, is prepared by reacting organic carboxylic acid ester, such as acetic acid ester, of racemic (R.S)-α-cyano-3-phenoxybenzyl alcohol with an esterase, wherein the ester of (S)-(-)-α-cyano-3-phenoxybenzyl alcohol is predominantly hydrolyzed. Thus. asymmetric hydrolysis permits optical resolution of the (S)-(-)-isomer alcohol from the ester of its antipode, in a high optical purity. The esterase may be of microorganism or animal pancreas or liver.