Method for biotechnologically preparing optically active alpha-cyano-3-phenoxybenzyl alcohol
    3.
    发明公开
    Method for biotechnologically preparing optically active alpha-cyano-3-phenoxybenzyl alcohol 失效
    Verfahren zur生物技术Herstellung von optisch-aktivemα-氰基-3-苯氧基苄醇。

    公开(公告)号:EP0118163A1

    公开(公告)日:1984-09-12

    申请号:EP84300024.1

    申请日:1984-01-04

    IPC分类号: C12P13/00 A01N37/38

    摘要: (S)-α-cyano-3-phenoxybenzyl alcohol, which is the alcohol moiety of pyrethroids, effective insecticides, is prepared by reacting an ester of racemic (R,S)-a-cyano-3-phenoxybenzyl alcohol with an esterase, wherein the ester of (S)-α-cyano-3-phenoxybenzyl alcohol is predominantly hydrolyzed. Thus, asymmetric hydrolysis permits optical resolution of the (S)-isomer alcohol from the ester of its antipode efficiently. The esterase may be of microorganism or animal pancreas or liver.

    摘要翻译: 通过使外消旋(R,S)-α-氰基-3-苯氧基苄醇的酯与酯酶反应制备作为拟除虫菊酯的醇部分的(S)-α-氰基-3-苯氧基苄醇,其为有效的杀虫剂, 其中(S)-α-氰基-3-苯氧基苄醇的酯主要水解。 因此,不对称水解允许有效地从其对映体的酯的光学拆分(S) - 异构体醇。 酯酶可以是微生物或动物胰腺或肝脏。

    Method for biotechnologically preparing (S)-(-)-alpha-cyano-3-phenoxybenzyl alcohol
    6.
    发明公开
    Method for biotechnologically preparing (S)-(-)-alpha-cyano-3-phenoxybenzyl alcohol 失效
    (S) - ( - ) - α-氰基-3-苯氧基苄基醇的Verfahren zur生物技术。

    公开(公告)号:EP0080827A2

    公开(公告)日:1983-06-08

    申请号:EP82306125.4

    申请日:1982-11-17

    IPC分类号: C12P13/00 A01N37/38

    CPC分类号: C12P13/004

    摘要: (S)-(-)-α-cyano-3-phenoxybenzyl alcohol, which is the alcohol moiety of pyrethroids, effective insecticides, is prepared by reacting organic carboxylic acid ester, such as acetic acid ester, of racemic (R.S)-α-cyano-3-phenoxybenzyl alcohol with an esterase, wherein the ester of (S)-(-)-α-cyano-3-phenoxybenzyl alcohol is predominantly hydrolyzed. Thus. asymmetric hydrolysis permits optical resolution of the (S)-(-)-isomer alcohol from the ester of its antipode, in a high optical purity. The esterase may be of microorganism or animal pancreas or liver.

    摘要翻译: (S) - ( - ) - α-氰基-3-苯氧基苄醇,其为拟除虫菊酯的醇部分,有效的杀虫剂,通过使有机羧酸酯如乙酸酯与外消旋(R,S) - α-氰基-3-苯氧基苄醇与酯酶,其中(S) - ( - ) - α-氰基-3-苯氧基苄醇的酯主要水解。 因此,不对称水解允许从其对映体的酯以高光学纯度旋光拆分(S) - ( - ) - 异构体醇。 酯酶可以是微生物或动物胰腺或肝脏。