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    Modified aluminium hydrides, their preparation and their use in reducing acetylnaphthalene derivatives
    11.
    发明公开
    Modified aluminium hydrides, their preparation and their use in reducing acetylnaphthalene derivatives 失效
    改性铝酸盐，它们的制备及其在减少乙酰苯胺衍生物中的用途

    公开(公告)号：EP0035355A3

    公开(公告)日：1982-01-20

    申请号：EP81300754

    申请日：1981-02-24

    申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

    发明人： Terashima, Shiro ,  Koga, Kenji ,  Tanno, Norihiko

    IPC分类号： C07C91/16 ,  C07C87/62 ,  C07C41/18 ,  C07C43/253 ,  C07F05/06

    CPC分类号： C07C43/23 ,  C07F5/069

    摘要： A modified lithium aluminium hydride type reducing agent is useful for reducing organic compounds having a carbonyl group-(ketone group of aldehyde group) in their structure to the corresponding alcohols. It is obtained by reacting one equivalent of lithium aluminium hydride with one equivalent of an optically active N-substituted ephedrine of the formula,
    (wherein R, is a C i -C 4 alkyl group or benzyl group and Ph is phenyl group)
    and two equivalents of an N-substituted aniline of the formula,
    (wherein R 2 is a C 1 -C 4 alkyl group or phenyl group, and Ph is phenyl group). The reducing agent is particularly useful for reducing 2-acetyl-5, 8-dimethoxy-3, 4-dihydronaphthalene to the corresponding 2-(1'-hydroxy)ethyl compound, and, by selecting a particular modified aluminium hydride the unsymmetrical ketone can be reduced to selectively produce either an alcohol in which the asymmetric carbon atom bonded to the hydroxy group is in R-configuration or an alcohol in which said asymmetric carbon atom is in S-configuration.