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    Modified aluminium hydrides, their preparation and their use in reducing acetylnaphthalene derivatives
    4.
    发明公开
    Modified aluminium hydrides, their preparation and their use in reducing acetylnaphthalene derivatives 失效
    改性铝氢化物，其制备方法及其用于降低Acetylnaphthalen衍生物使用。

    公开(公告)号：EP0035355A2

    公开(公告)日：1981-09-09

    申请号：EP81300754.9

    申请日：1981-02-24

    申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

    发明人： Terashima, Shiro ,  Koga, Kenji ,  Tanno, Norihiko

    IPC分类号： C07C91/16 ,  C07C87/62 ,  C07C41/18 ,  C07C43/253 ,  C07F5/06

    CPC分类号： C07C43/23 ,  C07F5/069

    摘要： A modified lithium aluminium hydride type reducing agent is useful for reducing organic compounds having a carbonyl group-(ketone group of aldehyde group) in their structure to the corresponding alcohols. It is obtained by reacting one equivalent of lithium aluminium hydride with one equivalent of an optically active N-substituted ephedrine of the formula,
    (wherein R, is a C i -C 4 alkyl group or benzyl group and Ph is phenyl group)
    and two equivalents of an N-substituted aniline of the formula,
    (wherein R 2 is a C 1 -C 4 alkyl group or phenyl group, and Ph is phenyl group).
    The reducing agent is particularly useful for reducing 2-acetyl-5, 8-dimethoxy-3, 4-dihydronaphthalene to the corresponding 2-(1'-hydroxy)ethyl compound, and, by selecting a particular modified aluminium hydride the unsymmetrical ketone can be reduced to selectively produce either an alcohol in which the asymmetric carbon atom bonded to the hydroxy group is in R-configuration or an alcohol in which said asymmetric carbon atom is in S-configuration.

    摘要翻译： 一种改性氢化锂铝型还原剂为还原具有羰基（酮基醛基的）在它们的结构为相应的醇的有机化合物是有用的。 它是通过使一个当量的氢化铝锂与一个当量的光学活性的N- substituiertem麻黄碱DER Formel，... ...（worin R1是C1-C4烷基或苯基，和Ph是苯基团的获得 ）...和式H的N-取代的苯胺的两个当量 - @ - PH ...... worin R2是C1-C4烷基或苯基，和Ph是苯基）。 ... 还原剂为还原2-乙酰基5,8二甲氧基-3,4-二氢化萘为相应的2-（1分钟羟基）乙基化合物是特别有用的，并且，通过选择特定的改性铝 氢化物的不对称的酮可以减小，以产生选择性要么醇，其中结合于羟基的不对称碳原子是R构型或在哪醇的所述不对称碳原子为S-构型。

    Novel aminonaphthacene derivatives and process for preparation thereof
    6.
    发明公开
    Novel aminonaphthacene derivatives and process for preparation thereof 失效
    Aminonaphthacen的衍生物及其制备方法。

    公开(公告)号：EP0094059A1

    公开(公告)日：1983-11-16

    申请号：EP83104493.8

    申请日：1983-05-06

    申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

    发明人： Ishizumi, Kikuo ,  Muramatsu, Michihisa ,  Sato, Hiromi ,  Tanno, Norihiko ,  Yoshida, Noboru

    IPC分类号： C07C97/18 ,  A61K31/135

    CPC分类号： A61K31/135

    摘要： An aminonaphthacene derivative of the formula:
    wherein R 1 is a hydrogen atom, a hydroxyl group or a lower alkoxy group, R 2 is a hydrogen atom or a hydroxyl group, R 3 is a hydrogen atom or a lower alkanoyl group and R 4 and R 5 are, same or different, each a hydrogen atom, a lower alkyl group, a lower hydroxyalkyl group or a group of the formula:
    wherein A is an alkylene group which may have one or more lower alkyl substituent(s) and R 6 and R 7 are, same or different, each a hydrogen atom, a lower alkyl group, a lower hydroxyalkyl group or a lower aminoalkyl group, and an acid addition salt thereof, which is useful as anti-tumor agent.

    Aminonaphthacene derivatives and their production
    9.
    发明公开
    Aminonaphthacene derivatives and their production 失效
    氨基萘磺酸衍生物和Herstellung。

    公开(公告)号：EP0071483A2

    公开(公告)日：1983-02-09

    申请号：EP82304021.7

    申请日：1982-07-29

    申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

    发明人： Ishizumi, Kikuo ,  Muramatsu, Michihisa ,  Sato, Hiromi ,  Yoshida, Noboru ,  Tanno, Norihiko

    IPC分类号： C07C97/18 ,  C07D317/28

    CPC分类号： C07D317/28

    摘要： Aminonaphthacene derivatives of the formula:
    wherein R 1 is a hydrogen atom, a hydroxyl group or a lower alkoxy group, R 2 is a hydrogen atom or a hydroxyl group, R 3 and R 4 are each a lower alkyl group or, when taken together, represent an ethylenedioxy group or an oxo group and R 6 and R 8 are each a hydrogen atom, a lower alkyl group or a group of the formula: -A-Q (in which A is an alkylene group optionally bearing at least one lower alkyl and Q is a hydrogen atom, a hydroxyl group, a lower alkoxy group or a group of the formula:
    wherein R 7 and R 8 are each a hydrogen atom, a lower alkyl group, a benzyl group, a hydroxy (lower) alkyl group or an amino (lower) alkyl group or, when taken together with the adjacent nitrogen atom to which they are attached, represent a 5 to 7-membered nitrogen-containing ring optionally having an additional nitrogen or oxygen atom in the ring and optionally bearing any substituent on the ring) or, R 5 and R 6 when taken together with the adjacent nitrogen atom to which they are attached, represent a 5 to 7-membered nitrogen-containing ring optionally having an additional nitrogen or oxygen atom in the ring and optionally bearing any substituent on the ring, and their acid addition salts, which are useful as anti-tumor agents.

    摘要翻译： 其中R 1为氢原子，羟基或低级烷氧基，R 2为氢原子或羟基，R 3和R 4为氢， 4>各自为低级烷基，或者一起表示亚乙二氧基或氧代基，R 5和R 6各自为氢原子，低级烷基或下式基团： - AQ（其中A是任选带有至少一个低级烷基的亚烷基，Q是氢原子，羟基，低级烷氧基或下式的基团：... 其中R 7和R 8是氢原子，低级烷基，苄基，羟基（低级）烷基或氨基（低级）烷基，当与它们所连接的相邻氮原子一起代表 5至7元含氮环，任选在环中具有额外的氮原子或氧原子，并且任选在环上带有任何取代基）或R 5和R 6当 与它们所连接的相邻氮原子一起代表在环中任选具有额外的氮或氧原子且任选地在环上具有任何取代基的5至7元含氮环，及其酸加成盐， 其可用作抗肿瘤剂。