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    Modified aluminium hydrides, their preparation and their use in reducing acetylnaphthalene derivatives
    1.
    发明公开
    Modified aluminium hydrides, their preparation and their use in reducing acetylnaphthalene derivatives 失效
    改性铝酸盐，它们的制备及其在减少乙酰苯胺衍生物中的用途

    公开(公告)号：EP0035355A3

    公开(公告)日：1982-01-20

    申请号：EP81300754

    申请日：1981-02-24

    申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

    发明人： Terashima, Shiro ,  Koga, Kenji ,  Tanno, Norihiko

    IPC分类号： C07C91/16 ,  C07C87/62 ,  C07C41/18 ,  C07C43/253 ,  C07F05/06

    CPC分类号： C07C43/23 ,  C07F5/069

    摘要： A modified lithium aluminium hydride type reducing agent is useful for reducing organic compounds having a carbonyl group-(ketone group of aldehyde group) in their structure to the corresponding alcohols. It is obtained by reacting one equivalent of lithium aluminium hydride with one equivalent of an optically active N-substituted ephedrine of the formula,
    (wherein R, is a C i -C 4 alkyl group or benzyl group and Ph is phenyl group)
    and two equivalents of an N-substituted aniline of the formula,
    (wherein R 2 is a C 1 -C 4 alkyl group or phenyl group, and Ph is phenyl group). The reducing agent is particularly useful for reducing 2-acetyl-5, 8-dimethoxy-3, 4-dihydronaphthalene to the corresponding 2-(1'-hydroxy)ethyl compound, and, by selecting a particular modified aluminium hydride the unsymmetrical ketone can be reduced to selectively produce either an alcohol in which the asymmetric carbon atom bonded to the hydroxy group is in R-configuration or an alcohol in which said asymmetric carbon atom is in S-configuration.

    Preparation of optically active 4-demethoxydaunomycinone
    3.
    发明公开
    Preparation of optically active 4-demethoxydaunomycinone 失效
    Herstellung von optisch aktiven Derivaten von 4-Demethoxydaunomycinon。

    公开(公告)号：EP0087807A1

    公开(公告)日：1983-09-07

    申请号：EP83101995.5

    申请日：1983-03-01

    申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

    发明人： Terashima, Shiro ,  Tamoto, Katsumi ,  Sugimori, Masamichi ,  Koga, Kenji

    IPC分类号： C07C50/38 ,  C07B57/00 ,  C07C43/178 ,  C07D317/22

    CPC分类号： C07C43/1786

    摘要： Optical resolution of a racemic mixture of the a-hydroxyketone of the formula:
    by the use of an optical isomer of the α-glycol of the formula:
    wherein R is agroup of the formula:
    and X is a halogen atom or a lower alkyl group as the resolving agent and racemization of the optically active a-hydroxyketone of the formula IVa and IVb through its methylated product.

    摘要翻译： 通过使用下式的α-二醇的光学异构体：CHEM>和X是通式为：CHEM的α-羟基酮的外消旋混合物的光学拆分是卤素原子或低级烷基作为 拆分剂和式IVa和IVb的光学活性α-羟基酮通过其甲基化产物的外消旋化。

    Modified aluminium hydrides, their preparation and their use in reducing acetylnaphthalene derivatives
    5.
    发明公开
    Modified aluminium hydrides, their preparation and their use in reducing acetylnaphthalene derivatives 失效
    改性铝氢化物，其制备方法及其用于降低Acetylnaphthalen衍生物使用。

    公开(公告)号：EP0035355A2

    公开(公告)日：1981-09-09

    申请号：EP81300754.9

    申请日：1981-02-24

    申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

    发明人： Terashima, Shiro ,  Koga, Kenji ,  Tanno, Norihiko

    IPC分类号： C07C91/16 ,  C07C87/62 ,  C07C41/18 ,  C07C43/253 ,  C07F5/06

    CPC分类号： C07C43/23 ,  C07F5/069

    摘要： A modified lithium aluminium hydride type reducing agent is useful for reducing organic compounds having a carbonyl group-(ketone group of aldehyde group) in their structure to the corresponding alcohols. It is obtained by reacting one equivalent of lithium aluminium hydride with one equivalent of an optically active N-substituted ephedrine of the formula,
    (wherein R, is a C i -C 4 alkyl group or benzyl group and Ph is phenyl group)
    and two equivalents of an N-substituted aniline of the formula,
    (wherein R 2 is a C 1 -C 4 alkyl group or phenyl group, and Ph is phenyl group).
    The reducing agent is particularly useful for reducing 2-acetyl-5, 8-dimethoxy-3, 4-dihydronaphthalene to the corresponding 2-(1'-hydroxy)ethyl compound, and, by selecting a particular modified aluminium hydride the unsymmetrical ketone can be reduced to selectively produce either an alcohol in which the asymmetric carbon atom bonded to the hydroxy group is in R-configuration or an alcohol in which said asymmetric carbon atom is in S-configuration.

    摘要翻译： 一种改性氢化锂铝型还原剂为还原具有羰基（酮基醛基的）在它们的结构为相应的醇的有机化合物是有用的。 它是通过使一个当量的氢化铝锂与一个当量的光学活性的N- substituiertem麻黄碱DER Formel，... ...（worin R1是C1-C4烷基或苯基，和Ph是苯基团的获得 ）...和式H的N-取代的苯胺的两个当量 - @ - PH ...... worin R2是C1-C4烷基或苯基，和Ph是苯基）。 ... 还原剂为还原2-乙酰基5,8二甲氧基-3,4-二氢化萘为相应的2-（1分钟羟基）乙基化合物是特别有用的，并且，通过选择特定的改性铝 氢化物的不对称的酮可以减小，以产生选择性要么醇，其中结合于羟基的不对称碳原子是R构型或在哪醇的所述不对称碳原子为S-构型。