-
11.发明公开LYCOPENE INTERMEDIATE 1, 3, 6, 10-TETRA-DOUBLE BOND PENTADEC-PHOSPHONATE, PREPARATION METHOD AND APPLICATION THEREOF 有权番茄红素中间体1,3,6-,10-四 - 双键十五碳磷酸酯及其制备方法和应用
公开(公告)号：EP2551272A1
公开(公告)日：2013-01-30
申请号：EP11752834.9
申请日：2011-03-09
发明人： SHEN, Runpu , YE, Weidong , LAO, Xuejun , SONG, Xiaohua , LIU, Luo , WU, Chunlei , WU, Yibin , HU, Liujiang
CPC分类号： C07F9/4015
摘要： The invention relates to a novel important lycopene intermediate 3, 7, 11-trimethyl-1, 3, 6, 10-tetraene-dodecyl diethyl phosphonate. A current lycopene intermediate 2, 4, 6, 10-tetra-double bond pentadec-carbon phosphonate is difficult to synthesize. The invention provides a novel intermediate, which has the following synthesis steps of: preparing 2, 6, 10-trimethyl-3, 5, 9-undecane triene-1-aldehyde from pseudoionone; preparing 2, 6, 10-trimethyl-2, 5, 9-undecane triene-1-aldehyde from the 2, 6, 10-trimethyl-3, 5, 9-undecane triene-1-aldehyde; and subjecting the 2, 6, 10-trimethyl-2, 5, 9-undecane triene-1-aldehyde and tetraethyl methylenediphosphonate to condensation reaction to obtain target product. The invention can generate novel intermediate from raw material pseudoionone only by four reactions, thus the reactions are easy to control and great industrial value are achieved.
摘要翻译： 本发明涉及新的重要番茄红素中间体3,7,11-三甲基-1,3,6,10-四烯十二烷基二乙基膦酸酯。 目前的番茄红素中间体2,4,6,10-四双键十五碳膦酸盐难以合成。 本发明提供了一种新型中间体，其具有以下合成步骤：由假性紫罗酮制备2,6,10-三甲基-3,5,9-十一烷三烯-1-醛; 由2,6,10-三甲基-3,5,9-十一烷三烯-1-醛制备2,6,10-三甲基-2,5,9-十一烷三烯-1-醛; 并使2,6,10-三甲基-2,5,9-十一烷三烯-1-醛和亚甲基二膦酸四乙酯发生缩合反应，得到目标产物。 本发明只需4个反应即可由原料假性紫罗酮生成新型中间体，反应易控制，具有很大的工业价值。
-
12.发明公开
公开(公告)号：EP3822257A1
公开(公告)日：2021-05-19
申请号：EP19834997.9
申请日：2019-07-09
发明人： XU, Xinde , XIE, Tian , WANG, Shengfan , WANG, Qiuyan , ZHENG, Jianyong , ZENG, Zhaowu , YIN, Xiaopu , LAO, Xuejun , SHAO, Kangzhong
IPC分类号： C07C403/24
摘要： The present invention provides a method for extracting and isolating a lutein crystal from a vegetable oil resin containing a lutein diester, comprising the following steps: a) dissolving lipase into deionized water to form an enzyme solution; b) dissolving a lutein extract into an alcohol solvent containing the deionized water to form a uniform alcohol solution; c) adding the enzyme solution to the alcohol solution for performing hydrolysis, and stirring same to obtain a lutein solution; d) filtering and performing filtration isolation on the lutein solution to obtain a crystalline; e) re-dissolving the crystalline into a non-polar organic solvent, and using the deionized water for washing a water-soluble impurity; f) recycling the organic solvent and cooling same to obtain a recrystallization; and g) isolating the recrystallization and drying same to obtain the lutein crystal. According to the present invention, the selectivity is strong, the reaction time is short, no waste water is produced, the process is environment-friendly, the obtained lutein crystal is high in purity and yield, and the method is suitable for industrial production.
-
13.发明授权PREPARING METHOD FOR XANTHOPHYLL CRYSTALS WITH HIGHER CONTENT OF ZEAXANTHIN FROM PLANT OLEORESIN 有权植物松油醇高含量黄芩苷的XTHTHLYLL晶体的制备方法
公开(公告)号：EP2522655B1
公开(公告)日：2017-07-19
申请号：EP10841903.7
申请日：2010-03-18
发明人： XU, Xinde , SHAO, Bin , CHAO, Hongjuan , LAO, Xuejun , SUN, Xiaoxia
IPC分类号： C07C403/24 , C09B61/00
CPC分类号： C07C403/24 , C07C2601/16 , C09B61/00
-
14.发明公开PREPARING METHOD FOR XANTHOPHYLL CRYSTALS WITH HIGHER CONTENT OF ZEAXANTHIN FROM PLANT OLEORESIN 有权HERSTELLUNGSVERFAHRENFÜRXANTHOPHYLLKRISTALLE MIT HOHEM ANTEIL AN ZEAXANTHIN AUS PFLANZLICHEM OLEORESIN
公开(公告)号：EP2522655A1
公开(公告)日：2012-11-14
申请号：EP10841903.7
申请日：2010-03-18
发明人： XU, Xinde , SHAO, Bin , CHAO, Hongjuan , LAO, Xuejun , SUN, Xiaoxia
IPC分类号： C07C403/24
CPC分类号： C07C403/24 , C07C2601/16 , C09B61/00
摘要： The invention makes public a preparing method for xanthophyll crystals with higher content of zeaxanthin from plant oleoresin. The current methods generally are to get quite pure crystal forms of xanthophyll or zeaxanthin, and they refer to several separation steps. The invention mixes the xanthophyll diester-containing plant oleoresins and food grade alcohol solvents to form even solution, and then soap-dissolve the solution under an alkaline environment; then replenish organic solvents and emulsifiers into the reaction solution and drop some alkali solution into the solution to make partial xanthophyll crystals be tranformed to be zeaxanthin through epimerization reaction; after the reaction is finished, add the mixed solvents of alcohol solvent and water to separate out the crystals; use the method of centrifugation or filtration to get the crystals; wash the crystals several times with the mixed solution of deionized water and alcohols to remove the impurities among the crystals; recrystallize the gained crystals with absolute ethyl alcohol, and then dry the crystals to get the products. The invention can gain mixture crystals that contain xanthophyll and zeaxanthin at one time in quite high collection rate, and it is convenient for the followed product application.
摘要翻译： 本发明公开了植物油树脂中玉米黄质含量较高的叶黄素晶体的制备方法。 目前的方法通常是获得相当纯的叶黄素或玉米黄质的晶体形式，它们是指几个分离步骤。 本发明混合含有叶黄素二酯的植物油树脂和食品级醇溶剂，形成均匀的溶液，然后在碱性环境下将溶液皂溶; 然后将有机溶剂和乳化剂补充到反应溶液中，并将一些碱溶液滴入溶液中，使部分叶黄素晶体通过差向异构化反应转化为玉米黄质; 反应完成后，加入醇溶剂和水的混合溶剂分离出晶体; 使用离心或过滤方法得到晶体; 用去离子水和醇的混合溶液洗涤晶体几次以除去晶体中的杂质; 用无水乙醇重结晶获得的晶体，然后干燥晶体得到产物。 本发明可以以相当高的收集速度一次获得含有叶黄素和玉米黄质的混合物晶体，并且对于随后的产品应用是方便的。
-
公开(公告)号：EP3848032A1
公开(公告)日：2021-07-14
申请号：EP19857755.3
申请日：2019-09-03
发明人： SHAO, Dong , SUN, Xinqiang , LAO, Xuejun , LIU, Wei , ZHANG, Weicai
IPC分类号： A61K31/4745 , A61P43/00
摘要： The present invention relates to an application of pyrroloquinoline quinone (PQQ) in the preparation of a medicament used for preventing and treating acute altitude sickness and acute altitude hypoxia injury. Pyrroloquinoline quinone has the effect of preventing and treating acute high altitude hypoxia injury, and as a drug for the prevention and treatment of acute altitude sickness, the efficacy thereof is equivalent to that of acetazolamide, however acetazolamide has many toxic side effects; meanwhile, as a coenzyme, pyrroloquinoline quinone has the advantages of low toxicity and is easily acceptance by patients. In addition, by means of exhaustive swimming experiments of mice under the conditions of hypoxic exposure, PQQ has been shown to have the feature characteristics of improving the working capabilities of a subject at a high altitude, however acetazolamide has not been found to have said effect.
-
16.发明公开CAROTENOID OIL SUSPENSION WITH HIGH BIOAVAILABILITY AND PREPARATION METHOD THEREOF 有权CAROTINOIDUSLSPENSION麻省理工学院HOHERBIOVERFÜGBARKEITUND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2656834A1
公开(公告)日：2013-10-30
申请号：EP11851084.1
申请日：2011-01-30
发明人： XU, Xinde , SHAO, Bin , LAO, Xuejun
IPC分类号： A61K9/10 , A61K31/01 , A61K31/015
CPC分类号： A23D9/007 , A23K20/158 , A23K20/179 , A61K9/10 , A61K31/015 , A61K47/44
摘要： A carotenoid oil suspension and preparation method thereof are provided. The method includes the following steps: a) mixing carotenoid with organic solvent, heating the mixture to dissolve the carotenoid sufficiently to obtain carotenoid solution; b) introducing the carotenoid solution obtained in step a) into a vegetable oil solution stirred in high speed by spraying, meanwhile recovering the organic solvent generated during spraying under vacuum condition, then, simultaneously completing recycling and spraying, thereafter, obtaining carotenoid oil suspension; wherein, the carotenoid oil suspension comprises a carotenoid crystal with an average particle size of less than 5µm. The method is applicable in industrial scale with continuous operation and increased efficiency without additional carotenoid crystal grinding processes, and decreases the degradation of carotenoid during the preparation process of carotenoid oil suspension.
摘要翻译： 提供类胡萝卜素油悬浮液及其制备方法。 该方法包括以下步骤：a）将类胡萝卜素与有机溶剂混合，加热混合物以充分溶解类胡萝卜素，得到类胡萝卜素溶液; b）将步骤a）中得到的类胡萝卜素溶液加入到通过喷雾高速搅拌的植物油溶液中，同时在真空条件下回收喷雾过程中产生的有机溶剂，同时完成回收和喷涂，然后得到类胡萝卜素油悬浮液; 其中，类胡萝卜素油悬浮液包含平均粒径小于5μm的类胡萝卜素晶体。 该方法适用于工业规模，连续操作，效率高，无需额外的类胡萝卜素晶体研磨工艺，降低类胡萝卜素油悬浮液制备过程中类胡萝卜素的降解。
-
17.发明授权LYCOPENE INTERMEDIATE 1, 3, 6, 10-TETRA-DOUBLE BOND PENTADEC-PHOSPHONATE, PREPARATION METHOD AND APPLICATION THEREOF 有权LYCOPINZWISCHENSTOFF 1,3,6,10四双重约束PENDTADECPHOSPHONAT，方法及其应用
公开(公告)号：EP2551272B1
公开(公告)日：2017-03-08
申请号：EP11752834.9
申请日：2011-03-09
发明人： SHEN, Runpu , YE, Weidong , LAO, Xuejun , SONG, Xiaohua , LIU, Luo , WU, Chunlei , WU, Yibin , HU, Liujiang
CPC分类号： C07F9/4015
-
18.发明公开REDUCTION TYPE COENZYME Q10 POWDER, COMPOSITION THEREOF, AND PREPARATION METHOD THEREOF 审中-公开辅酶Q10粉的原型，其组成及其制造方法
公开(公告)号：EP2995605A1
公开(公告)日：2016-03-16
申请号：EP14788075.1
申请日：2014-03-14
发明人： XU, Xinde , CHEN, Gang , LAO, Xuejun , ZHANG, Lihua , SUN, Xiaoxia , JIANG, Xiaoyue
CPC分类号： A61K9/1617 , A23L33/10 , A23V2002/00 , A61K9/0053 , A61K9/1652 , A61K9/1658 , A61K9/4858 , A61K9/4866 , A61K9/4875 , A61K31/09 , C07C41/26 , C07C41/34 , C12P7/66 , C07C43/23
摘要： The present invention describes a reduction type coenzyme Q10 powder, a composition thereof, and a preparation method thereof. The reduction type coenzyme Q10 powder is obtained by reacting an oxidation type coenzyme Q10 with the presence of a reducing agent, removing an organic solvent and other purities after the reaction is finished to obtain an oil-soluble reduction type coenzyme Q10 liquid, and then directly performing prill formation with cold wind on an obtained reduction type coenzyme Q10 greasy substance. The reduction type coenzyme Q10 powder has a lower crystallinity, and in a Cu-Kα X-ray diffraction spectrum, has a strong peak at a diffraction angle 2θ being 18.9 DEG , and has a very strong absorption peak at a diffraction angle 2θ being 22.8 DEG. The reduction type coenzyme Q10 powder is in an incompletely crystallized state, has desirable stability and desirable oral bioavailability.
-
19.发明授权CAROTENOID OIL SUSPENSION WITH HIGH BIOAVAILABILITY AND PREPARATION METHOD THEREOF 有权CAROTINOIDÖLSUSPENSION生物利用度高及其制造方法
公开(公告)号：EP2656834B1
公开(公告)日：2016-01-06
申请号：EP11851084.1
申请日：2011-01-30
发明人： XU, Xinde , SHAO, Bin , LAO, Xuejun
IPC分类号： A61K9/10 , A61K31/01 , A61K31/015
CPC分类号： A23D9/007 , A23K20/158 , A23K20/179 , A61K9/10 , A61K31/015 , A61K47/44
摘要： A carotenoid oil suspension and preparation method thereof are provided. The method includes the following steps: a) mixing carotenoid with organic solvent, heating the mixture to dissolve the carotenoid sufficiently to obtain carotenoid solution; b) introducing the carotenoid solution obtained in step a) into a vegetable oil solution stirred in high speed by spraying, meanwhile recovering the organic solvent generated during spraying under vacuum condition, then, simultaneously completing recycling and spraying, thereafter, obtaining carotenoid oil suspension; wherein, the carotenoid oil suspension comprises a carotenoid crystal with an average particle size of less than 5µm. The method is applicable in industrial scale with continuous operation and increased efficiency without additional carotenoid crystal grinding processes, and decreases the degradation of carotenoid during the preparation process of carotenoid oil suspension.
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.018 秒)
